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News Effect of Telmisartan and Losartan on Bone Turnover Markers in Patients with Newly Diagnosed Stage I Hypertension

Telmisartan, an AT1 receptor blocker for angiotensin II and partial agonist of the PPAR-γ receptor, is a widely used antihypertensive. The PPAR-γ receptor plays a role in the genesis of osteoblasts and osteoclasts, and antidiabetic drugs from the thiazolidinedione group, which act as agonists of this receptor, have a known inhibitory effect on bone metabolism and increase the risk of non-traumatic fractures. Knowledge regarding the potential similar effects of telmisartan is limited. The following study compared the effects of telmisartan and losartan (an AT1 blocker without agonistic effect on PPAR-γ) on bone turnover markers in patients with newly diagnosed hypertension.

Source: Sartans in the Treatment of Hypertension 12. 8. 2021

News Can antihypertensive treatment also have a beneficial effect on neurocognitive functions?

Observational studies suggest that a desirable side effect of AT1 receptor blockers for angiotensin II (sartans) could be cognitive protection of patients. A randomized study published last year evaluated the potential positive impact of candesartan and lisinopril on neurocognitive functions in older patients with mild cognitive impairment (MCI).

Source: Sartans in the Treatment of Hypertension 14. 6. 2021

News How to Manage Thromboprophylaxis in Obese and Extremely Obese Patients?

Doctors often address the question of how to dose thromboprophylaxis in overweight individuals. The goal is to ensure effective protection against thrombotic complications in stressful situations, such as hospitalization or surgical procedures, without increasing the risk of bleeding.

Source: Thromboprophylaxis 18. 2. 2020

News Expanded Hemodialysis as an Alternative to Hemodiafiltration

Expanded hemodialysis is a new type of therapy that effectively removes middle molecules from the blood of dialysis patients. The aim of the Spanish authors was to compare its efficiency with hemodiafiltration in terms of clearance of middle molecules in an open randomized clinical study.

Source: Chronic Kidney Disease 9. 12. 2021

News Administration of Low-Molecular-Weight Heparin After Hemorrhagic Stroke: What Is the Appropriate Timing?

Hemorrhagic stroke (HS) is a condition that raises doubts and concerns about anticoagulation. Is early prevention of thromboembolic complications appropriate?

Source: Thromboprophylaxis 30. 9. 2021

News Biocompatibility of 3D Printed Materials –⁠ Their Comparison, Legislation, and Practice

Printing three-dimensional (3D) objects brings new possibilities for producing personalized implants, prosthetics, and other medical devices in healthcare. One area where this technology can improve current practice is the printing of tracheostomy tubes for use in patients after laryngectomy. However, it is crucial to ensure the biocompatibility of the materials used for printing. In November 2023, a study comparing 3D printer materials in terms of their susceptibility to the growth of bacterial biofilms from Staphylococcus aureus was published in the journal 3D Printing in Medicine.

Source: 27. 3. 2024

News New Therapeutic Options in Light of Current Knowledge on the Pathogenesis of Atopic Dermatitis

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense itching and recurrent eczematous lesions. AD is diagnosed in 2 out of 10 children and often persists into adulthood. In developed countries, it is the most common skin disease with a lifetime prevalence exceeding 15%. However, it is also very diverse due to a wide range of clinical phenotypes reflecting various pathophysiological mechanisms and interactions between genetics, the immune system, and the environment. So, what have we learned about atopic dermatitis from recent research, and how has this translated into advances in its treatment?

Source: Biological Treatment 14. 11. 2022

News Pregabalin in the Treatment of Postherpetic Neuralgia Resistant to Gabapentin

Pregabalin appears to be an effective aid in patients with postherpetic neuralgia. This is evidenced by numerous clinical studies comparing the effects of pregabalin and gabapentin. It can be expected to alleviate painful symptoms and improve sleep quality, thereby significantly enhancing patients' quality of life.

Source: Neuropathic Pain 21. 5. 2021

News Romiplostim brings benefit also to patients with ITP lasting less than 1 year

What is the role of second-line therapy, in this case romiplostim, in the management of adult ITP patients who have not yet reached the chronic phase of the disease?

Source: Immune Thrombocytopenia 21. 11. 2023

News Valproate for Acute Mania: Is Practice Really Evidence-Based and Recommended?

Authors from the University of Western Ontario conducted an audit in an acute psychiatric intake unit to determine whether the prescription of valproate there corresponded to evidence-based recommendations.

Source: Bipolar Disorder 18. 2. 2020

News Identification of patients with advanced Parkinson's disease suitable for device-aided therapy (DAT)

To properly implement device-aided therapy in Parkinson's disease (PD) management, it is essential to timely identify patients in advanced stages of the disease who might benefit from this therapeutic approach. We summarize the useful tools that doctors can use to find these patients.

Source: Parkinson's Disease 14. 9. 2023

News Meta-Analysis of the Results of Studies Comparing the Effectiveness of Manual and Sonic Toothbrushes

Brushing teeth is a fundamental means of maintaining good oral hygiene. While many people still rely on using manual toothbrushes, brushing with electric toothbrushes has also gradually gained significant popularity. Several studies comparing the effectiveness and gentleness of these two approaches have been conducted in the past, followed by a meta-analysis of their results.

Source: Dental Care 21. 4. 2023

News 6 Possible Benefits of Adding Empagliflozin to Metformin

Currently, there is intense discussion about the advantages of sodium-glucose co-transporter 2 inhibitors (SGLT2i, also known as gliflozins) in terms of their cardio and nephroprotective properties. Below, we summarize the proven beneficial effects specifically associated with adding empagliflozin to metformin and mention the indications for empagliflozin, which are reimbursed.

Source: Diabetes 14. 11. 2022

News Hybrid Cooperative Complexes in the Treatment of Osteoarthritis

Intra-articular application of corticosteroids and hyaluronic acid is part of the treatment of osteoarthritis (OA) in patients for whom oral or topical treatment does not provide sufficient response. The following text addresses the lubricating and protective properties of synovial fluid and the related choice of appropriate intra-articular viscosupplementation, with emphasis on innovative molecules with high concentrations of hyaluronic acid and low viscosity.

Source: Pain Management 18. 6. 2024

Články časopisu Current results of colorectal cancer screening and potential value of colon capsule endoscopy in the Czech Republic

Author of the article: O. Ngo, R. Chloupková, Suchánek Š., Zavoral M., Dušek L., O. Májek Source: Gastroenterologie a hepatologie | 5/2019 31. 10. 2019