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News Efficacy and Safety of Soybean and Avocado Unsaponifiables in the Treatment of Knee and Hip Osteoarthritis

Osteoarthritis represents a chronic irreversible degenerative joint disease, the prevalence of which increases with age. Various approaches are applied in therapy, including the administration of preparations aimed at reducing symptoms of the disease and slowing its progression. A recently published study provides current insights into the efficacy and safety of unsaponifiable soybean and avocado oil in the treatment of hip and knee osteoarthritis.

Source: Osteoarthritis Therapy 4. 4. 2020

News ESC 2022: Heart Failure with Preserved Ejection Fraction as an Underdiagnosed Problem: How to Increase Its Detection in Everyday Practice?

During this year's European Society of Cardiology Congress (ESC 2022), alarming information was shared, indicating that heart failure with preserved ejection fraction of the left ventricle (HFpEF) is likely underdiagnosed in clinical practice, necessitating improved identification and detection of patients with this condition. One of the symposiums addressed not only the reasons why many patients with HFpEF are misdiagnosed.

Source: Heart Failure 14. 11. 2022

News Effect of Combination of Dorzolamide with Timolol for Wet Age-Related Macular Degeneration

In some eyes with wet age-related macular degeneration (AMD), exudation does not stop despite frequent intravitreal injections of vascular endothelial factor blockers (anti-VEGF). Adjuvant therapy that reduces edema may improve overall treatment outcomes concerning visual functions. A recently published multicenter randomized clinical study evaluated the effect of local therapy combining dorzolamide and timolol in patients with this issue.

Source: Glaucoma 3. 7. 2020

News Alarming Data on Prevalence and Insufficient Treatment of Hypertension in Working Age −⁠ Another Underestimated 'Civilization Epidemic'?

The National Cardiology Information System (NKIS), developed by the Czech Society of Cardiology in collaboration with the Institute of Health Information and Statistics (ÚZIS), has provided the first data on the prevalence of hypertension in the Czech population. It revealed that even the treatment of a significant risk factor for cardiovascular diseases –⁠ hypertension –⁠ is not well managed in the Czech Republic. About 40% of patients with hypertension do not have regular preventive check-ups with their general practitioner, while 40% of hypertensive patients are simultaneously of working age.

Source: Risk factors of cardiovascular diseases 10. 6. 2024

News Preserving Quality of Life for Patients During Palliative Treatment of Triple-Negative Breast Cancer

An analysis of the quality of life of patients treated with a combination of atezolizumab with nab-paclitaxel for metastatic triple-negative breast cancer was published in the Annals of Oncology journal.

Source: Breast Carcinoma 28. 5. 2020

News Probiotic L. reuteri in combination with vitamin D3 and krill oil suppresses experimental intestinal inflammation

Previous placebo-controlled studies have shown that oral administration of a probiotic containing Lactobacillus reuteri is associated with a significant increase in plasma levels of 25-hydroxyvitamin D. According to a recent experimental work, the combination of this probiotic with vitamin D3 and krill oil leads to the suppression of intestinal mucosal inflammation.

Source: GI, colic and microbiome 29. 10. 2021

News Impact of Azacitidine Maintenance Therapy on Survival of Patients with AML in Remission Depending on Initial Chemotherapy

The QUAZAR AML-001 study showed that oral azacitidine maintenance therapy significantly prolongs relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy (including induction ± consolidation therapy), who are not candidates for hematopoietic stem cell transplantation (HSCT), compared to placebo. In October 2023, results of a subgroup analysis of patients stratified according to the use/non-use of consolidation chemotherapy and the number of consolidation chemotherapy cycles administered before entering the study were published.

Source: Acute Myeloid Leukemia 24. 1. 2024

News Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract

Brazilian authors published a review of available information on the mechanism of action of metamizole, its impact on gastrointestinal tract motility, its effect on the gastric mucosa, and its antispasmodic effects.

Source: Analgesia 2. 11. 2020

News New Strategies in the Treatment of Schizophrenia

Schizophrenia was primarily associated with dopamine dysfunction. Previous and current treatments have mainly targeted the mesolimbic dopamine pathway in the CNS and D2 receptors. However, the cited review article primarily addresses newer treatment targets and strategies beyond the dopamine hypothesis.

Source: Schizophrenia and Antipsychotics 30. 8. 2021

News Impact of Antiemetic Prophylaxis on Quality of Life of Patients Treated with Chemotherapy –⁠ Data from Practice

Chemotherapy-induced nausea and vomiting (CINV) is a relatively common complication of cancer treatment with a significantly negative impact on patients' quality of life. A large prospective analysis of real-world clinical practice data was conducted in Germany, examining the efficacy and safety of treatment with the oral combination of netupitant and palonosetron and the impact of this therapy on patients' quality of life.

Source: Antiemetic Therapy 8. 4. 2021

News FOLFOXIRI and Panitumumab in mCRC Treatment –⁠ Improvement in Treatment Response and Metastasis Resectability

For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment, the FOLFOX (5-fluorouracil/leucovorin, oxaliplatin) or FOLFIRI (5-fluorouracil/leucovorin, irinotecan) regimens combined with monoclonal antibodies represent the standard first-line treatment. The FOLFOXIRI regimen, which is another option, was developed to further enhance the efficacy of chemotherapy. The German oncologists' VOLFI study investigated the effectiveness of combining targeted therapy and triplet chemotherapy compared to chemotherapy alone in previously untreated patients with mCRC without RAS oncogene mutation.

Source: Colorectal Cancer 21. 4. 2020

Články časopisu A severe course of acquired haemophilia A –⁠ case report

Author of the article: M. Chobola, V. Šrámek, J. Hruda Source: Anesteziologie a intenzivní medicína | 2/2012 30. 5. 2012

News Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis

A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic inflammatory markers.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 20. 6. 2022

News Recommend Erdostein for children when treating with amoxicillin –⁠ symptoms of cough improve in almost 50% of cases within 3 days

Acute respiratory infections are usually treated empirically in primary care as the causative agent is not known. Amoxicillin is among the most commonly chosen antibiotics. Erdostein is a suitable addition to this antibiotic treatment for several reasons.

Source: Cough Therapy 19. 1. 2021

News Does Administration of Saline Make a Crucial Difference Compared to Balanced Crystalloids in Critically Ill Patients?

A study published in the New England Journal of Medicine provided data on mortality and deterioration of renal function in adult patients in intensive care units, depending on whether they received saline or balanced crystalloid solutions for fluid replacement.

Source: Parenteral Nutrition 4. 10. 2021