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News Preserving Quality of Life for Patients During Palliative Treatment of Triple-Negative Breast Cancer

An analysis of the quality of life of patients treated with a combination of atezolizumab with nab-paclitaxel for metastatic triple-negative breast cancer was published in the Annals of Oncology journal.

Source: Breast Carcinoma 28. 5. 2020

News Probiotic L. reuteri in combination with vitamin D3 and krill oil suppresses experimental intestinal inflammation

Previous placebo-controlled studies have shown that oral administration of a probiotic containing Lactobacillus reuteri is associated with a significant increase in plasma levels of 25-hydroxyvitamin D. According to a recent experimental work, the combination of this probiotic with vitamin D3 and krill oil leads to the suppression of intestinal mucosal inflammation.

Source: GI, colic and microbiome 29. 10. 2021

News Impact of Azacitidine Maintenance Therapy on Survival of Patients with AML in Remission Depending on Initial Chemotherapy

The QUAZAR AML-001 study showed that oral azacitidine maintenance therapy significantly prolongs relapse-free survival (RFS) and overall survival (OS) in patients with acute myeloid leukemia (AML) in first remission after intensive chemotherapy (including induction ± consolidation therapy), who are not candidates for hematopoietic stem cell transplantation (HSCT), compared to placebo. In October 2023, results of a subgroup analysis of patients stratified according to the use/non-use of consolidation chemotherapy and the number of consolidation chemotherapy cycles administered before entering the study were published.

Source: Acute Myeloid Leukemia 24. 1. 2024

News Current Insights into the Antispasmodic and Analgesic Effects of Metamizole on the Gastrointestinal Tract

Brazilian authors published a review of available information on the mechanism of action of metamizole, its impact on gastrointestinal tract motility, its effect on the gastric mucosa, and its antispasmodic effects.

Source: Analgesia 2. 11. 2020

News New Strategies in the Treatment of Schizophrenia

Schizophrenia was primarily associated with dopamine dysfunction. Previous and current treatments have mainly targeted the mesolimbic dopamine pathway in the CNS and D2 receptors. However, the cited review article primarily addresses newer treatment targets and strategies beyond the dopamine hypothesis.

Source: Schizophrenia and Antipsychotics 30. 8. 2021

News Impact of Antiemetic Prophylaxis on Quality of Life of Patients Treated with Chemotherapy –⁠ Data from Practice

Chemotherapy-induced nausea and vomiting (CINV) is a relatively common complication of cancer treatment with a significantly negative impact on patients' quality of life. A large prospective analysis of real-world clinical practice data was conducted in Germany, examining the efficacy and safety of treatment with the oral combination of netupitant and palonosetron and the impact of this therapy on patients' quality of life.

Source: Antiemetic Therapy 8. 4. 2021

News FOLFOXIRI and Panitumumab in mCRC Treatment –⁠ Improvement in Treatment Response and Metastasis Resectability

For patients with metastatic colorectal cancer (mCRC) who are able to undergo intensive treatment, the FOLFOX (5-fluorouracil/leucovorin, oxaliplatin) or FOLFIRI (5-fluorouracil/leucovorin, irinotecan) regimens combined with monoclonal antibodies represent the standard first-line treatment. The FOLFOXIRI regimen, which is another option, was developed to further enhance the efficacy of chemotherapy. The German oncologists' VOLFI study investigated the effectiveness of combining targeted therapy and triplet chemotherapy compared to chemotherapy alone in previously untreated patients with mCRC without RAS oncogene mutation.

Source: Colorectal Cancer 21. 4. 2020

Články časopisu A severe course of acquired haemophilia A –⁠ case report

Author of the article: M. Chobola, V. Šrámek, J. Hruda Source: Anesteziologie a intenzivní medicína | 2/2012 30. 5. 2012

News Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis

A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic inflammatory markers.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 20. 6. 2022

News Recommend Erdostein for children when treating with amoxicillin –⁠ symptoms of cough improve in almost 50% of cases within 3 days

Acute respiratory infections are usually treated empirically in primary care as the causative agent is not known. Amoxicillin is among the most commonly chosen antibiotics. Erdostein is a suitable addition to this antibiotic treatment for several reasons.

Source: Cough Therapy 19. 1. 2021

News Does Administration of Saline Make a Crucial Difference Compared to Balanced Crystalloids in Critically Ill Patients?

A study published in the New England Journal of Medicine provided data on mortality and deterioration of renal function in adult patients in intensive care units, depending on whether they received saline or balanced crystalloid solutions for fluid replacement.

Source: Parenteral Nutrition 4. 10. 2021

News Effect of Telmisartan and Losartan on Bone Turnover Markers in Patients with Newly Diagnosed Stage I Hypertension

Telmisartan, an AT1 receptor blocker for angiotensin II and partial agonist of the PPAR-γ receptor, is a widely used antihypertensive. The PPAR-γ receptor plays a role in the genesis of osteoblasts and osteoclasts, and antidiabetic drugs from the thiazolidinedione group, which act as agonists of this receptor, have a known inhibitory effect on bone metabolism and increase the risk of non-traumatic fractures. Knowledge regarding the potential similar effects of telmisartan is limited. The following study compared the effects of telmisartan and losartan (an AT1 blocker without agonistic effect on PPAR-γ) on bone turnover markers in patients with newly diagnosed hypertension.

Source: Sartans in the Treatment of Hypertension 12. 8. 2021

News Can antihypertensive treatment also have a beneficial effect on neurocognitive functions?

Observational studies suggest that a desirable side effect of AT1 receptor blockers for angiotensin II (sartans) could be cognitive protection of patients. A randomized study published last year evaluated the potential positive impact of candesartan and lisinopril on neurocognitive functions in older patients with mild cognitive impairment (MCI).

Source: Sartans in the Treatment of Hypertension 14. 6. 2021

News How to Manage Thromboprophylaxis in Obese and Extremely Obese Patients?

Doctors often address the question of how to dose thromboprophylaxis in overweight individuals. The goal is to ensure effective protection against thrombotic complications in stressful situations, such as hospitalization or surgical procedures, without increasing the risk of bleeding.

Source: Thromboprophylaxis 18. 2. 2020

News Expanded Hemodialysis as an Alternative to Hemodiafiltration

Expanded hemodialysis is a new type of therapy that effectively removes middle molecules from the blood of dialysis patients. The aim of the Spanish authors was to compare its efficiency with hemodiafiltration in terms of clearance of middle molecules in an open randomized clinical study.

Source: Chronic Kidney Disease 9. 12. 2021