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News Position of Levodropropizine in Cough Therapy
An international group of specialists focused in 2016–2017 on a detailed evaluation of current options for cough therapy. The authors based their analysis on individually prepared reviews using Medline and Embase databases, and they presented their work's results last year in the journal Pulmonary Pharmacology & Therapeutics.
News Scientists Create First Functional Brain Tissue Using 3D Printing
A research team from the University of Wisconsin-Madison has successfully printed the first ever functional brain tissue using a commercial 3D printer in their laboratory. This breakthrough may be beneficial not only for scientists studying the pathogenesis of neurological and neurodevelopmental diseases but could even mark the beginning of a journey towards a deeper understanding of how neurons function, how brain development occurred, and how different parts of the brain communicate with each other.
News Current Findings on Progressive Fibrosis in Interstitial Lung Disease
Leading pulmonologists around the world recently published the first of a series of three review articles on interstitial lung disease in The Lancet Respiratory Medicine journal. This article focuses on histopathology and the relationship of this disease with lung fibrosis. It also addresses the question of whether progressive lung tissue fibrosis pertains only to usual interstitial pneumonia.
News Safety and Effectiveness of Lurasidone in Adolescents with Schizophrenia
An open-label extension of a placebo-controlled study involving 271 patients aged 13–17 years with schizophrenia showed minimal impact on body weight, lipid levels, prolactin, and blood glucose during 2 years of treatment while maintaining and deepening the alleviation of schizophrenia symptoms.
News Telmisartan, amlodipine, and chlorthalidone in a low-dose fixed triple combination – better control of target blood pressure values?
The secondary analysis of the TRIUMPH study, recently published in JAMA Cardiology, is likely the first published assessment of time spent in the target blood pressure (BP) range during antihypertensive treatment. This parameter was assessed in patients with moderate hypertension using a low-dose triple combination of antihypertensives (telmisartan 20 mg, amlodipine 2.5 mg, and chlorthalidone 12.5 mg) compared to usual care.
News MUDr. Jana Zárubová: Experiences with buccal midazolam in real practice are positive and we can significantly improve patients' quality of life
Recently, it has emerged as an alternative to traditionally rectally administered diazepam for stopping prolonged convulsive seizures in patients with epilepsy. What can buccal midazolam offer them and how has it proven itself in real practice? MUDr. Jana Zárubová from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague describes.
News A Brief History of Deep Vein Thrombosis Treatment – From Antiquity to the Present
Deep vein thrombosis is among the common diseases that have accompanied humanity since its inception. Due to the low specificity of its clinical presentation (in contrast to, for example, varicose veins of the lower limbs), however, the disease long went undescribed in literature. The first descriptions of deep vein thrombosis did not appear until the Middle Ages – and from that moment, the gradual development of its treatment began. We offer you a brief but remarkable historical excursion in three stages.
News The Potential of Vinpocetine in the Treatment of Cardiovascular Diseases
Vinpocetine is a nootropic indicated for the symptomatic treatment of cerebral ischemic hypoperfusion, vascular dementia, and reducing the psychological and neurological consequences of cerebral blood supply disorders. Due to its excellent safety profile, tolerance, and complex mechanism of action, it is currently being studied in experimental models of various disorders such as obesity and cardiovascular (CV) diseases including atherosclerosis, neointimal hyperplasia, vasoconstriction, pathological heart remodeling, and ischemic stroke (iCMP). We present an overview of the research findings on vinpocetine in CV diseases.
News Advances in the Treatment of Myasthenia Gravis on the Horizon
The research of new drugs for the generalized form of myasthenia gravis has made significant progress in recent years. How is the new specific therapy performing? And are we heading towards a radical change in treatment strategy?
News Prof. Petra Lišková: Prevention of Dry Eye Syndrome is Difficult but Not Impossible
Dry eye syndrome is one of the most common ophthalmological problems, and its incidence is rising. Ophthalmologist Prof. MUDr. Petra Lišková, Ph.D., from the Clinic of Pediatrics and Hereditary Metabolic Disorders of the First Faculty of Medicine, Charles University, and University Hospital in Prague, explains how these difficulties arise and why patients should visit an eye doctor rather than relying solely on self-treatment.
News Prim. Václava Adámková: People mistakenly believe that there are enough antibiotics and that they will always handle infections
According to the World Health Organization (WHO), by 2050, infections untreatable with antibiotics could become the leading cause of death, surpassing cardiovascular and oncological diseases. Rising antimicrobial resistance was one of the main topics at the VIII Congress of Clinical Microbiology, Infectious Diseases, and Epidemiology (KMINE 2022), held in September in Prague. The topic was also the focus of the expert block ‘ATB stewardship,’ where epidemiologist Petr Smejkal, infectologist Aleš Chrdle, and microbiologist Václava Adámková discussed possible solutions to this global problem. We asked Adámková to summarize insights into the presented issues for us.
News Thyroid Function During COVID-19 Illness and After Recovery
Acute infection with the SARS-CoV-2 coronavirus has varying impacts on different organ systems of the human body. Until now, it has not been certain how precisely it affects the endocrine system, especially the thyroid gland. The study presented below investigated how thyroid function changes in relation to the course of COVID-19 infection.
News Continuous Infusion of Tiapride in the Treatment of Hyperactive Delirium – Case Study
Spanish authors recently published a case study of a young man with pharmacologically unmanageable agitation delirium following multiple injuries from a traffic accident, which resolved within 3 days with continuous infusion of tiapride.
News Targeted Therapy for DLBCL Patients Who Cannot Undergo Bone Marrow Transplant
An international team of hemato-oncologists has been involved in testing polatuzumab vedotin in patients with diffuse large B-cell lymphoma (DLBCL) who have an unfavorable prognosis. In an article published at the beginning of 2020 in the Journal of Clinical Oncology, they analyze data collected in the early phases of clinical evaluation.
News Can We Lump All Gabapentinoids Together?
General practitioners often encounter peripheral neuropathic pain in their practice. One of the primary modalities for treating both painful diabetic neuropathy and postherpetic neuralgia is gabapentinoids, specifically gabapentin and pregabalin. Are these substances completely interchangeable, or do their efficacy and practical application differ?
News Diabetic Cardiovascular Autonomic Neuropathy: How to Detect This Serious Diagnosis and Why Is It Dangerous?
Diabetic autonomic neuropathy can affect various organ systems. Cardiovascular autonomic neuropathy is one of its most severe forms with a significant impact on patient morbidity and mortality. How can it be detected in clinical practice?
News Subclinical Hypothyroidism in Pregnancy: How Great Are the Real Risks and Can They Be Effectively Reduced?
The aim of the meta-analysis by authors from the Mayo Clinic was to describe the impact of subclinical hypothyroidism on the course of pregnancy and the effect of levothyroxine replacement therapy in reducing the risk of possible complications.
News Biocompatibility of 3D Printed Materials – Their Comparison, Legislation, and Practice
Printing three-dimensional (3D) objects brings new possibilities for producing personalized implants, prosthetics, and other medical devices in healthcare. One area where this technology can improve current practice is the printing of tracheostomy tubes for use in patients after laryngectomy. However, it is crucial to ensure the biocompatibility of the materials used for printing. In November 2023, a study comparing 3D printer materials in terms of their susceptibility to the growth of bacterial biofilms from Staphylococcus aureus was published in the journal 3D Printing in Medicine.
News Telmisartan – antihypertensive with cardioprotective effects
Sartans are potent inhibitors of the AT1 receptor for angiotensin II widely used in the therapy of arterial hypertension. Given that chronic activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role not only in the pathogenesis of arterial hypertension but also in the pathogenesis of atherosclerosis and the development of other cardiovascular diseases, the question arises whether the administration of sartans is associated with a broader cardioprotective effect. Telmisartan is the first representative of this group of antihypertensives for which a positive cardioprotective effect has been demonstrated.
News Aloe vera Extract in the Therapy of Irritable Bowel Syndrome
The therapy options for irritable bowel syndrome are relatively limited, thus complementary and alternative treatments besides conventional therapy are applied. Many patients report that using Aloe vera extract helps reduce their disease symptoms, although there is a lack of valid evidence from clinical studies. The pilot study presented below focused on evaluating the efficacy of Aloe vera extract compared to placebo in several dozen patients with irritable bowel syndrome.
News Prevalence and Manifestations of Cow Milk Protein Allergy
The prevalence of food allergies is on the rise, along with the severity and variety of their manifestations. The most common food allergy in infants and toddlers is cow milk protein allergy (CMPA).