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News Patient with Diabetes: When to Follow Up and When to Refer to a Specialist?
It is most often the general practitioner (GP) who first diagnoses diabetes. Whether during preventive check-ups, preoperative examinations, or based on the patient's clinical issues. After diagnosing diabetes, however, the GP faces a difficult decision: Will they continue to monitor and treat the patient themselves, or will they refer them to a diabetologist?
News Anticoagulation Therapy in Patients on ECMO During the COVID-19 Pandemic
In the past 2 years, the use of extracorporeal membrane oxygenation (ECMO) in intensive care units (ICU) has increased in connection with the treatment of severe COVID-19 pneumonia. Dr. Pilar Marcos Neira from the ICU at Germans Trias i Pujol Hospital in Barcelona has compiled a summary of updated knowledge on anticoagulation therapy in these patients.
News Can We Reach Brain Metastases of Lung Cancer with Anti-EGFR Targeted Therapy?
Information on the penetration of epidermal growth factor receptor tyrosine kinase inhibitors (anti-EGFR TKIs) through the blood-brain barrier primarily comes from preclinical testing. In clinical studies, its effectiveness in patients with brain metastases can be an indicator of its penetration. However, a truly robust analysis is lacking. Until one is available, we can preliminarily evaluate the available data.
News Effect of Zolpidem on Sleep Quality and Other Parameters in Patients During the Perioperative Period
Sleep quality is an important factor influencing functional outcomes, pain intensity, and patient satisfaction during the perioperative period. Sleep disturbances are a common problem among patients post-surgery. A prospective study evaluated the effect of zolpidem on sleep quality and other parameters in patients undergoing total hip arthroplasty for advanced osteoarthritis.
News Prim. MUDr. Gustáv Ondrejka: Biological treatment of asthma eliminates the need for systemic corticotherapy
Despite advances in the therapy of bronchial asthma, a portion of patients still do not achieve the desired control of the disease. The introduction of biological treatment marked a significant milestone in management, improving the prognosis for patients previously dependent on long-term systemic corticotherapy with all its negative impacts. The recently approved reimbursement for dupilumab expands treatment options for patients with severe asthma, relieving patients of common asthma comorbidities. The current perspective on the treatment of bronchial asthma is provided by the head of the Pulmonary Department at KNTB Zlín, which includes the Center for the Diagnosis and Treatment of Severe Forms of Bronchial Asthma, Prim. MUDr. Gustáv Ondrejka, Ph.D.
News How to Navigate the Challenges of Anticoagulant Therapy in Pregnant Women − A Case Study
Every carrier of a mechanical heart valve is also on anticoagulant therapy. Warfarin is most commonly used for this purpose, but it is not suitable during pregnancy due to the risk of embryopathy. So how should we approach patients with artificial valves who wish to become pregnant? The following case study presents one option.
News Traveling with MS – Is Vaccination a Limitation?
What about the need for vaccination when traveling abroad? Which vaccines should you be cautious about? And how to time vaccination concerning disease activity and the individual medications used in multiple sclerosis (MS) therapy?
News Pharmacotherapy of Chronic Heart Failure with Reduced EF LV - Latest ESC Recommendations
The European Society of Cardiology (ESC) issued an update in 2021 for the diagnosis and treatment of heart failure. We summarize the essential points regarding the pharmacotherapy of chronic heart failure with reduced ejection fraction.
News Probiotics as a Means to Reduce the Incidence of Streptococcus Mutans
Data from a prospective study examining the effects of probiotics on the oral microbiome show the ability of orally administered probiotics to reduce the incidence of Streptococcus mutans and also positively affect the presence of lactobacilli in the oral cavity.
News What FVIII Levels Are Ideal for Preventing Bleeding in Hemophilia A?
Recent studies indicate that target trough levels of factor 1–3% during prophylactic treatment are insufficient to fully prevent clinical and subclinical bleeding. With a sustained FVIII level > 15%, as shown in studies with mild hemophiliacs, spontaneous bleeding is very rare. This raises the question of whether achieving zero bleeding incidence with FVIII replacement therapy is possible and whether it can be a realistic goal. This topic was also explored in a presentation by Dr. Ester Zápotocká from the Clinic of Pediatric Hematology and Oncology, 2nd Faculty of Medicine, Charles University and Motol University Hospital in Prague.
News Long-term Safety of Dupilumab in Adult Patients with Moderate to Severe Atopic Dermatitis
Moderate to severe atopic dermatitis (AD) often requires systemic therapy. The long-term safety of dupilumab in patients with this condition was evaluated in an open-label extension (OLE) of the LIBERTY AD study, the results of which were recently published.
News Micronized Diosmin Obtained Reimbursement, Based on Its Therapeutic Interchangeability with MPFF
On January 11, 2022, the State Institute for Drug Control (SÚKL) issued a decision on the determination of the amount and conditions of reimbursement from health insurance for a drug containing micronized diosmin. The reimbursement is valid from March 1, 2022.
News Eletriptan as an effective and safe drug in acute migraine therapy
In the pharmacotherapy of acute migraine attacks, a pharmacologically diverse group of triptans is particularly used. The choice of the right antimigraine drug should be individualized, based on the intersection of the patient's nature of complaints and the pharmacological profile of the drug. The following text briefly summarizes the basic characteristics and profile of eletriptan.
News Spiolto Respimat System – Innovation for Easier Inhalation
Inhalation delivery is the most preferred method of drug administration in chronic obstructive pulmonary disease and bronchial asthma. The effectiveness of therapy is also conditioned by the correct inhalation technique. The aim of the following article is a brief comparison of inhalation systems, focusing on a new addition to the group of aerosol inhalers.
News Teriflunomide in the Treatment of RRMS: The Best Working Drug Is the One That the Patient Actually Takes
Teriflunomide is an oral disease-modifying drug (DMD) used in the therapy of relapsing-remitting multiple sclerosis (RRMS). The authors of the cited American study assessed adherence to this treatment and subsequently the effect of adherence on the occurrence of RRMS relapses and the utilization of healthcare services during the first year following the initial prescription of teriflunomide.
News Rebound effect after denosumab discontinuation in a patient with lung cancer
The case study of a patient with metastatic lung cancer describes the emergence of vertebral fractures following the discontinuation of denosumab. This antiresorptive treatment was halted prophylactically to reduce the risk of osteonecrosis in connection with a planned dental procedure. Fifteen months after receiving the last dose of denosumab, the patient experienced atraumatic compression fractures of the spine requiring kyphoplasty to alleviate symptoms. Other causes of the fractures were ruled out.
News Classification and Management of Chronic Wounds
Chronic wounds are common comorbidities that increase the morbidity and mortality of patients. Common types of chronic wounds on the lower extremities include arterial, venous, and diabetic ulcers, as well as pressure ulcers. Despite their frequent occurrence, they are often poorly treated. In addition to diagnosing the etiology of chronic wounds and specific therapies, moist wound healing plays a crucial role in the treatment, such as the application of hydrocolloids and hydrogels.
News Impact of Dabigatran and Warfarin Treatment on the Risk of Acute Kidney Injury in Patients with Atrial Fibrillation
What clinical characteristics in patients with non-valvular atrial fibrillation may indicate a higher risk of acute kidney injury? Does the modality of anticoagulation therapy play a role in its incidence? These questions were the focus of an extensive retrospective study conducted in an Asian setting.
News “Customized Schizophrenia Treatment”: Benefits of Therapeutic Innovations in Inpatient and Outpatient Care Thanks to Gentler Antipsychotics
In the field of schizophrenia treatment, the possibility of significantly greater individualization, brought about by gentler antipsychotics, is currently a hot topic. A major focus is the differences in schizophrenia therapy during hospitalization and subsequently in outpatient care. These topics were also addressed in a seminar called “Customized Schizophrenia Treatment,” supported by Angelini, which took place in Brno.
News Possible Uses of Desodrop in Therapy and Prevention of Ophthalmological Diseases
The medical device Desodrop is the first topical eye preparation based on ozone, intended for the prevention and therapy of eye infections and other diseases. Its efficacy and safety have been demonstrated through numerous experimental studies and clinical trials, making it a suitable alternative for topical therapy in children and adults.