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News Association between Hypothyroidism, Depression, and Anxiety Disorder – Results of Meta-Analyses
The prevalence of autoimmune thyroiditis in the USA ranges between 4 and 13%. Subclinical hypothyroidism affects 3–8.5% of the general population. Patients with this condition are at risk not only from somatic manifestations. The meta-analyses presented below examined the association between hypothyroidism and the incidence of psychiatric disorders – depressive and anxiety disorders. One of the meta-analyses also evaluated the effect of levothyroxine administration on the incidence of depression in individuals with subclinical hypothyroidism.
News Importance of Testing for Iron Deficiency in Patients with Chronic Heart Failure and Treatment Options
Intravenous iron application in patients with heart failure and iron deficiency is now part of ESC guidelines aimed at improving symptoms, increasing exercise tolerance and quality of life in these patients, and simultaneously reducing the risk of hospitalization or death from cardiovascular causes.
News Meta-analysis of the Effectiveness of Romosozumab in the Treatment of Postmenopausal Osteoporosis
Osteoporosis is a prevalent disease with unmet therapeutic needs. Whether the anti-sclerostin antibody romosozumab can offer an effective improvement in osteoporosis treatment outcomes in postmenopausal women was the central question addressed by the meta-analysis presented below.
News Current Expert Consensus on Prophylaxis of Individuals with Mild and Moderate Hemophilia A: These Patients Also Deserve Better Care
What is the importance of prophylaxis in 'non-severe' hemophilia A? Italian doctors have attempted to answer this question in their recent expert consensus.
News Prenatal Phenotype of Children with Noonan Syndrome
Until recently, the various phenotypes of RASopathies were clinically diagnosed only after birth. However, we are now striving for the earliest possible diagnosis, sometimes even prenatally. Ultrasound examination of the fetus during screening tests, focusing on certain characteristic morphological changes, plays a crucial role in this. In the case of pathological findings on imaging methods, molecular genetic testing and monitoring of pregnancy in specialized centers are indicated.
News Evaluation of Various VWF Concentrates Regarding Their Ability to Mediate Platelet Binding to Collagen
The study by London researchers on various VWF concentrates focused, among other things, on evaluating their ability to mediate platelet binding to collagen.
News Echocardiography in the Diagnosis of Cardiac Amyloidosis
Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?
News Comparison of Efficacy and Safety of Unsaponifiable Soy and Avocado Oil and Chondroitin Sulfate in the Treatment of Knee Osteoarthritis
Osteoarthritis is the most common joint disease in adult patients, with its prevalence increasing with age, and these issues most frequently affect the knee joint. In the treatment of knee osteoarthritis (gonarthrosis), the so-called symptomatically slow-acting drugs in the treatment of osteoarthritis (SYSADOA) are used, among which unsaponifiable soy and avocado oil or chondroitin sulfate are included. The study compared the efficacy and safety of these two drugs in a 6-month therapy of gonarthrosis.
News Obeticholic Acid in the Treatment of Patients with Primary Biliary Cholangitis with Inadequate Response to Ursodeoxycholic Acid in Real Practice
An interim analysis of the OCARELIFE observational study presented at the European Association for the Study of the Liver (EASL) congress in August 2020 attempted to evaluate whether the safety and efficacy of obeticholic acid treatment in patients with primary biliary cholangitis (PBC) under real-life conditions after 12 months correspond to the results of clinical trials.
News Don't Hesitate to Refer a Patient to the MS Center: Time is Brain! Or What Recent Czech Research Has Shown?
Time is crucial for every disease, but it is doubly true for diseases of the nervous system! Why is it important to diagnose and treat multiple sclerosis (MS) early? How to do it? And how are we doing with speed here in the Czech Republic?
News Ozanimod Expands Treatment Options for Ulcerative Colitis in Adult Patients
As a review article published last year in the journal Drugs suggests, ozanimod is an effective and well-tolerated medication for adult patients with moderate to severe ulcerative colitis (UC), both in the initial phase of treatment and in the maintenance phase after achieving remission.
News Subcutaneous vs. Intravenous Immunoglobulins in Patients with CLL
Secondary antibody immunodeficiency is a common complication in patients with chronic lymphocytic leukemia (CLL), and infections, along with secondary malignancies, are the leading cause of death in these patients. Hypogammaglobulinemia can be managed with immunoglobulin replacement therapy (IGRT). Besides the classic intravenous form (IVIG), a subcutaneous form (SCIG) is also available. An Italian retrospective study published in the journal Current Oncology compared their efficacy in secondary immunodeficiency in CLL patients.
News Instead of NSAIDs, consider combining paracetamol with a weak opioid
Chronic non-cancer pain is a problem that primary care physicians encounter on a daily basis. In the following interview with general practitioner MUDr. Michaela Wichová, we discuss how to approach a patient who complains of pain, what to remember during examination, and which analgesics are appropriate to start treatment.
News Therapy with Cyclosporine in the Context of the Coronavirus Pandemic
The rapid spread of the SARS-CoV-2 virus and the associated COVID-19 disease pandemic raises concerns about possible risks associated with immunosuppressive treatment of autoimmune diseases. Specifically, does the use of cyclosporine increase the risk of infection, or does it act protectively?
News HPD 2024: Czech data from real-world practice confirm that mucolytic treatment can reduce COPD exacerbations, even in the future
Chronic obstructive pulmonary disease (COPD) is a global issue. Does it create the same burden everywhere? How does it contribute to premature deaths? How do women cope with COPD, and what significant problem does it pose for them? What factors contribute to it not being considered solely a smoker's disease? Why is it appropriate to add mucoactive agents when trying to eliminate COPD exacerbations? What emerged from early COPD screening conducted in the Czech Republic, and what do Czech real-world data show regarding the effectiveness of erdosteine in exacerbations? And what should be included in the proper diagnosis and treatment of this disease? All these topics were covered in a lecture by the head of the Pulmonary Clinic of the Medical Faculty of Charles University and University Hospital Hradec Králové, Associate Professor Vladimír Koblížek, M.D., Ph.D., during the XXVIII Hradec Pneumology Days held from April 24-26, 2024.
News Dust Mite Allergies: Common Does Not Mean Trivial
Dust mite allergies are almost ubiquitous problems that we perceive as part of the 'broader norm.' However, patients do not see it this way, so we should not lose sight of it.
News Efficacy and Safety of the Combination of Telmisartan and Amlodipine with Hydrochlorothiazide in the Treatment of Hypertension
The aim of the study by Korean authors was to evaluate the efficacy and tolerability of the triple combination of telmisartan/amlodipine + hydrochlorothiazide (TAH) compared to the combination of telmisartan/amlodipine (TA) alone in patients with essential hypertension who did not respond sufficiently to a 4-week treatment with TA.
News Prescription Restrictions on Antidiabetics Authorized for Prescription by General Practitioners - Status as of October 2020
Diabetes mellitus (DM) has become an increasing problem worldwide in recent years. Long-term complications of DM lead to increased morbidity and mortality in the diabetic population, and their prevention determines the main treatment goals of DM. The treatment and management of patients with type 2 diabetes (DM2) are provided by either a general practitioner's office (GP) or a diabetology clinic. According to available data, over 200,000 patients with DM2 are currently treated and managed in GP offices.
News Parenteral Nutrition in Oncological Patients in Current ESPEN Recommendations
The current guidelines of the European Society for Clinical Nutrition and Metabolism (ESPEN) address nutritional care in oncological patients − current knowledge is summarized in a total of 43 recommendations, from which we select some key points, focusing primarily on parenteral nutrition in these patients.
News Viral or Bacterial Etiology? Old Question, New Methods...
The gold standard in the differential diagnosis of viral and bacterial respiratory infections is primarily C-reactive protein (CRP), followed by procalcitonin and interleukins. What are the pitfalls of their use, and what new methods of distinguishing the etiology of infectious diseases are currently being developed?