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News Use of Medical Cannabis in Patients with Fibromyalgia to Relieve Pain and Depression
Medical cannabis is prescribed to patients with chronic pain resistant to conventional treatments. The efficacy of tetrahydrocannabinol (THC) therapy in patients with fibromyalgia syndrome (FMS) was recently evaluated in a German study.
News COVID Pneumonia: How Can Erdosteine Help and What Did a Clinical Study Suggest?
When patients who have recovered from COVID pneumonia begin home treatment, they are often far from being symptom-free. General practitioners and outpatient pulmonologists often have to address these persistent symptoms. According to a study conducted by Recipharm, erdosteine may be a suitable adjunct treatment for these patients, even when they have negative COVID-19 tests. Why is this the case?
News American Heart Association: Side Effects of Statins Overview and Context
The American Heart Association (AHA) report provides an updated summary of knowledge on the safety of statin use. Despite warnings appearing in professional literature and general media, it assures that statins are an effective and safe modality for treating hypercholesterolemia.
News With Prof. Pavel Žák about Current Trends and Future Perspectives in Bone Marrow Transplantation and the Role of Carmustine in this Context
Hematopoietic stem cell transplantation has an indispensable place in the treatment of hemato-oncological diseases. We discuss current trends in this area, the significance and benefits of carmustine, the choice between BEAM and TEAM regimens, and the future of bone marrow transplantation in the context of new technologies with the head of the 4th Department of Hematology of the Faculty of Medicine, Charles University and University Hospital Hradec Králové, Prof. MUDr. Pavel Žák, Ph.D.
News Case of Heparin Allergy and Preventive Administration of Fondaparinux in Pregnancy – Case Study
The presented case study discusses a complicated case of a 40-year-old woman with essential thrombocythemia (ET), a history of intrauterine fetal death, and recurrent pulmonary embolism (PE). The patient developed an allergic reaction to low-molecular-weight heparin (LMWH) and was successfully managed with fondaparinux during pregnancy.
News Efficacy and Safety of Ozanimod in the Treatment of Relapsing-Remitting MS
The sphingosine-1-phosphate receptor (S1PR) modulator ozanimod has recently been approved for the treatment of active relapsing-remitting multiple sclerosis (RRMS). We summarize the current knowledge on its mechanism of action and the results of available studies evaluating its efficacy and safety.
News Tofacitinib Helps Restore Intestinal Epithelial Barrier
The Janus kinase inhibitor (JAKi) tofacitinib was relatively recently approved for the treatment of ulcerative colitis, but its effect on the intestinal epithelium remains a subject of research. The objective of the study presented below was to determine how tofacitinib aids in the repair of the cytokine-damaged intestinal epithelial cell barrier.
News Less Ventricular Arrhythmias and ICD Shocks After Introduction of Sacubitril/Valsartan
Is the decrease in the incidence of sudden cardiac death among patients using sacubitril/valsartan due to a lower risk of ventricular arrhythmias? And does it have anything to do with reverse left ventricular remodeling? A newly published study utilizing data from telemonitoring of patients with implanted devices focused on this.
News Limosilactobacillus reuteri as a supplement for improving periodontal health when oral hygiene is compromised
The effect of probiotics on periodontal health was investigated in a German study conducted on a group of sailors during their service at sea. Among the most common causes of the overgrowth of virulent pro-inflammatory microorganisms in the oral microbiota is impaired oral hygiene, which is significantly hindered in the conditions of a naval mission.
News Updated Recommendations for Treatment of von Willebrand Disease
In 2021, new recommendations for the therapy of von Willebrand disease (vWD) were published, based on a consensus by the American Society of Hematology (ASH), the International Society on Thrombosis and Haemostasis (ISTH), the National Hemophilia Foundation (NHF), and the World Federation of Hemophilia (WFH). The recommendations comprise a total of 12 points and address not only prophylaxis but also gynecological and obstetric issues, for example.
News What are the patients' needs during acute phase schizophrenia therapy and how to increase their adherence?
Treatment of an acute episode of schizophrenia usually requires hospitalization in a psychiatric ward. Even though hospitalization causes discomfort and represents a burden for many patients, it enables quick and relatively precise diagnosis and timely initiation of adequate treatment and monitoring of its effectiveness. Recommended practices guide how to conduct such diagnostics and therapy. One of the symposiums at the 65th Czech-Slovak Psychopharmacological Conference, which took place in mid-January 2023 in Mariánské Lázně, also focused on the management of care for these patients during the first days of hospitalization and after discharge from acute inpatient care.
News Severe Polytrauma in a Man with von Willebrand Disease − Case Report
The authors of a recently published case report present a case of multiple trauma (including brain injury) in a young man with von Willebrand disease (vWD) type 2A, in whom repeated administration of a concentrate containing von Willebrand factor (vWF) and coagulation factor VIII (FVIII) led to successful healing without neurological deficit.
News Nasal Smear as a Modern and Gentle Diagnostic Method for Allergic Rhinitis
Up to 130 million Europeans suffer from allergic rhinitis. Until now, standard diagnostic methods have been skin prick tests and laboratory blood tests. Both methods, however, present significant discomfort for many patients, and skin prick tests can also yield false-positive results. That's why researchers are focusing on new diagnostic possibilities for allergic rhinitis.
News Sotorasib in the Treatment of a Patient with NSCLC and DIC – A Case Report
Sotorasib is the first clinically used inhibitor of the KRAS oncogene with the G12C mutation. Its efficacy in the targeted treatment of non-small cell lung cancer (NSCLC) is still under research, but it is expected to bring significant benefits. The effect of sotorasib in a patient with a low baseline performance status (PS) and active brain metastases is presented in the following case report.
News Chronic Thromboembolic Pulmonary Hypertension – Overview of Pathophysiology, Diagnosis, and Treatment
Chronic thromboembolic pulmonary hypertension (CTEPH) is defined by the 2015 ESC/ERS guidelines as symptomatic pulmonary hypertension with persistent defects in lung perfusion despite adequate anticoagulation therapy. Significant values for determining a diagnosis of pulmonary hypertension are a mean pulmonary artery pressure > 25 mmHg. However, this condition remains significantly underdiagnosed, mainly due to its nonspecific symptoms.
News How to Achieve Left Ventricular Reverse Remodeling and Improve Outcomes in Heart Failure? Summary from HFA ESC Webinar
The current treatment algorithm for chronic heart failure with reduced ejection fraction (HFrEF) is well-known to clinicians. But how was its current form developed, and does it have the potential to change in the future? Experts discussed this and more at a web symposium on reverse remodeling sponsored by Novartis during the Heart Failure Association of the European Society of Cardiology (HFA ESC) congress. Notable presenters included HFA ESC President Professor Petar Seferovic and Professor Carolyn Lam from the National Heart Centre in Singapore.
News Echocardiography in the Diagnosis of Cardiac Amyloidosis
Cardiac amyloidosis remains a diagnostic challenge that requires great clinical vigilance. The imaging method of choice for evaluating heart failure suspected of amyloidosis is echocardiography. What findings are typical for patients with amyloidosis?
News Previous Treatment of Osteoporosis May Affect the Efficacy of Romosozumab
A study conducted by a team of authors from several clinical sites in Japan shows that the type and duration of previous osteoporosis treatment just before starting romosozumab affects its therapeutic effect. Romosozumab, as an antibody targeting sclerostin, stimulates bone formation and suppresses bone resorption. The authors of the study investigated whether the efficacy of 12-month treatment with romosozumab depends on the duration of prior treatment with teriparatide, denosumab, or oral bisphosphonates.
News Prognostic Significance of the Location of Colorectal Cancer Metastases
An Austrian study presented at the ESMO 2020 conference analyzed the relationship between the localization of colorectal cancer (CRC) metastases and patient survival, the time of metastasis detection, and RAS mutations.
News Ocrelizumab in the treatment of multiple sclerosis in real-world practice – a systematic review of published studies
In controlled study programs, ocrelizumab has demonstrated beneficial effects on improving clinical parameters in patients with multiple sclerosis, such as the annual relapse rate or confirmed disability progression. However, to get a complete picture of its clinical benefit, real-world evidence in a broad patient population is also needed. A systematic review of real-world clinical practice studies with ocrelizumab, published in March 2023, demonstrates its benefits in patients with relapsing-remitting multiple sclerosis (RRMS) and primary progressive multiple sclerosis (PPMS) in terms of relapse frequency, disease activity on MRI, disability, absence of disease activity (NEDA), and quality of life.
News New scoring system for predicting long-term survival of AML patients over 70 years and suitable for intensive chemotherapy
Based on the analysis of data from 3 large European registries (DATAML, SAL, and PETHEMA), a prognostic score for 5-year survival was created and validated for patients with acute myeloid leukemia (AML) who were given intensive chemotherapy. The ESS70+ score, determined based on parameters known at the time of diagnosis, is easily usable in routine practice for estimating overall survival of older AML patients and facilitates decisions about intensive chemotherapy.