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News Pathogenetic Mechanisms Underlying the Development and Progression of Interstitial Lung Diseases
Interstitial lung processes (ILP) represent an umbrella term for a wide range of nosological units that differ from each other in clinical course, prognosis, and pathogenesis. Most ILPs are characterized by inflammation or fibrosis of the interstitial space, leading to impaired gas exchange at the alveolocapillary membrane.
News Benefits of Physical Activity for Individuals with Hemophilia – Recommendations of the MEMO Group
Regular physical activity can increase joint stability and function in individuals with hemophilia, reduce the risk of injury, improve quality of life, and have other positive effects. However, according to recent findings, a regular exercise program is not sufficiently emphasized in comprehensive hemophilia therapy. Therefore, a group of Italian experts has created a consensus summarizing current knowledge about the benefits of exercise for individuals with hemophilia and recommendations for physical activity.
News Efficacy of Lorlatinib in Patients with ROS1-Positive NSCLC in Clinical Practice
Interesting real-world data have been brought by a study on the efficacy of lorlatinib in patients with non-small cell lung cancer (NSCLC) with a mutation in the ROS1 gene.
News How Do Vaccinated MS Patients Fare with COVID-19 Antibodies?
Which disease-modifying drugs for the treatment of multiple sclerosis (MS) reduce the humoral response to COVID-19 vaccination? And does the quantity of post-vaccination antibodies vary depending on the specific vaccine?
News Use of Bilastine in Pediatrics − Pathway to Improving Concentration and Performance of Young Allergy Sufferers
In the treatment of allergic diseases, especially in children, safety, good tolerability, simple dosing regimen, and non-sedative effects are the basic requirements for administered medications. Sedative side effects of treatment have a negative impact on sleep patterns and subsequently on children's performance in school. European professional societies recommend the use of modern second-generation antihistamines in the treatment of children. Studies confirm that bilastine, which meets these requirements, should be among the first-choice drugs.
News Does Administration of Saline Make a Crucial Difference Compared to Balanced Crystalloids in Critically Ill Patients?
A study published in the New England Journal of Medicine provided data on mortality and deterioration of renal function in adult patients in intensive care units, depending on whether they received saline or balanced crystalloid solutions for fluid replacement.
News Alzheimer's Disease: Diagnosis Step by Step in 4 Points
Alzheimer's disease is the most common cause of dementia. With the aging population, this topic is becoming increasingly relevant. How have the knowledge and diagnostic possibilities of the disease progressed over the past decades?
News Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis
A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic inflammatory markers.
News Is there a link between Parvovirus B19 infection and autoimmune thyroid diseases?
Autoimmune thyroid diseases are among the most common autoimmune disorders, with a worldwide prevalence of around 10%. The study presented below, recently published in the International Journal of Endocrinology and Metabolism, examined the connection between Parvovirus B19 infection (the cause of erythema infectiosum in children) and these diseases.
News Do Asthma Bronchiale and COPD Represent a Risk Factor for Severe COVID-19 and Death?
It is well known that patients with bronchial asthma and chronic obstructive pulmonary disease (COPD) have a higher risk of severe course of common viral respiratory diseases. A study by Belgian authors involving several hundred individuals evaluated the risk of ICU admission and death due to COVID-19 in patients with asthma and COPD compared to patients without these conditions. The other goal was to determine whether these risks are influenced by inhalation corticosteroid therapy or not.
News Long-term survival of a 50-year-old man with metastatic pancreatic cancer on a combination of nal-IRI + 5-FU/LV in 2nd line treatment − case study
A recently published case study from the Czech Republic describes a patient with progression of pancreatic cancer following surgical treatment and adjuvant chemotherapy, who achieved a one-year survival with good quality of life on a combination of nal-IRI + 5-FU/LV after the failure of gemcitabine + nab-paclitaxel in the 1st line of palliative treatment.
News Residual Pulmonary Hypertension After Endarterectomy: How Common Is It?
Pulmonary endarterectomy is the only potentially curative option in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH). What are its outcomes and in what percentage of cases does it lead to complete cure? A meta-analysis, significantly contributed to by Czech experts, was dedicated to the improvement of signs and symptoms of CTEPH after performing endarterectomy.
News Generic Substitution of Levothyroxine in Practice
The active ingredient levothyroxine is found in a significant number of medicinal products (MP) in the Czech Republic. The question of its generic substitution remains current, primarily because the previously published data tend to call for caution due to possible adverse effects on the patient.
News Pregabalin can be chosen as the 1st line treatment for postherpetic neuralgia
The efficacy of pregabalin in patients with postherpetic neuralgia has been demonstrated in 4 multicenter randomized double-blind placebo-controlled studies.
News Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control
The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement in quality of life in a prospective multicenter observational study on patients with diabetes and reduced gastrointestinal (GI) motility, but also to an improvement in glycemic parameters.
News Non-Invasive Diagnosis of Cardiac Amyloidosis
Cardiac amyloidosis has always been considered a rare pathology. However, thanks to advancements in imaging methods and laboratory tests, it is now evident that it might be responsible for a larger amount of cardiac diseases than previously thought. Which non-invasive diagnostic methods are useful in identifying cardiac amyloidosis?
News Li-Fraumeni Syndrome – Indication for Testing and Recommended Surveillance
A germline mutation of the TP53 gene, which causes Li-Fraumeni syndrome, results in a congenital predisposition to the occurrence of malignant tumors, such as pediatric malignancies, breast cancer, bone sarcomas, and others. We bring a summary of indications for testing the pathogenic variant of the TP53 gene according to the recommendations of the National Comprehensive Cancer Network (NCCN) and the surveillance program for carriers of this variant according to the consensus of the current recommendations of the European, American, Japanese, and Australian scientific societies compared to the recommendations of the Czech Oncology Society ČLS JEP.
News Prophylaxis with Enoxaparin After Total Knee or Hip Replacement
Venous thromboembolic disease is a significant cause of complications in surgical patients during and after hospitalization. The authors of a recently published Portuguese observational study evaluated the incidence of complications with prophylaxis using low-molecular-weight heparin (LMWH) enoxaparin in a population after hip or knee joint replacement.
News Safety Profile of Metamizole – A Systematic Review
Metamizole is a long-established non-steroidal analgesic used for acute and chronic pain management. A systematic review of the literature published in the Journal of Clinical Pharmacy and Therapeutics focused on the safety profile of this drug. Here, we present a summary of the most important findings.
News Idiopathic Thrombocytopenic Purpura with SARS-CoV-2 Infection
To date, 45 cases of idiopathic (autoimmune) thrombocytopenic purpura (ITP) in individuals with confirmed SARS-CoV-2 infection have been published in the literature. In September 2020, a review summarizing the clinical profile and treatment outcomes of ITP in these individuals was released.
News Analgesic Effects of Using Ringer's Solution in Wound Healing Management
Pain resulting from skin defects of various etiologies causes significant discomfort for the patient. However, wound care using Ringer's solution and the use of primary dressings, which include this solution to maintain a constant moist environment in the wound, can help address this problem.