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News New Strategies in the Treatment of Schizophrenia
Schizophrenia was primarily associated with dopamine dysfunction. Previous and current treatments have mainly targeted the mesolimbic dopamine pathway in the CNS and D2 receptors. However, the cited review article primarily addresses newer treatment targets and strategies beyond the dopamine hypothesis.
News One Step Closer to Understanding the Placebo Effect in Pain Treatment
Neuroscientists from the USA appear to have advanced our understanding of the placebo effect in pain relief. Their findings, recently published in Nature, open the possibility of influencing the described pain control pathway using drugs or neurostimulation.
News Risk of Thromboembolism in ITP
Among other possible comorbidities in patients with ITP, thromboembolism represents one of the potential issues that require special attention.
News Efficacy and Safety of Preservative-Free Latanoprost in the Treatment of Open-Angle Glaucoma and Elevated Intraocular Pressure – Results of a Meta-Analysis
Many eye drops for the treatment of glaucoma still contain preservatives today. However, these can cause eye irritation, so non-preservative formulations should be preferred. The following meta-analysis compared the efficacy and safety of antiglaucoma medications with and without preservatives.
News How to Set Individual Treatment Goals for Type 2 Diabetes?
Treatment goals for type 2 diabetes should always be set individually. In practice, this mainly involves an indicator of the success of long-term compensation – glycated hemoglobin (HbA1c). Recommendations for the diagnosis and treatment of diabetes for general practitioners from 2020 list different target HbA1c values according to the risk of hypoglycemia and other parameters. They also recall different target values for fit, frail, and dependent seniors.
News Most Common Dermatoses Around the Stoma
The incidence of stomal complications ranges between 20 and 70%. One type of complication is dermatoses affecting the peristomal skin. These issues can occur in the early postoperative period, but also several years later.
News Sonicare Technology as a Modern Means for Good Oral Hygiene
Sonicare technology was developed and introduced to the market by Philips 30 years ago. Since then, the range of products has expanded, and the use of sonic technology has become accessible to a wide spectrum of patients with various problems and needs.
News Comparison of the Effectiveness of Different Types of Toothbrushes in Orthodontic Patients
The aim of the study cited below was to evaluate the efficiency of a manual orthodontic brush, an electric toothbrush with an oscillating head, and a sonic toothbrush in controlling plaque, gingivitis, and interproximal bleeding in patients undergoing orthodontic treatment with fixed appliances and to compare their relative effectiveness.
News Prediabetes through the lens of current data and findings − and why hurry with intervention
Type 2 diabetes mellitus (DM2) is one of the most common causes of premature morbidity and mortality worldwide. The most serious impact on the health of the organism is mainly due to the macrovascular complications of this disease. However, their occurrence was often recorded before the diagnosis of DM2 was confirmed. Prediabetes itself thus represents a condition associated with the risk of developing cardiovascular (CV) complications with all their prognostic implications for patients.
News Early Tumor Regression as a Marker of Overall Survival in First-Line Treatment of mCRC
In the treatment of metastatic colorectal cancer (mCRC), prognostic factors besides overall survival (OS) and progression-free survival (PFS) include early tumor regression (ETS) and depth of response (DpR). Japanese authors presented the results of an analysis at the European Society for Clinical Oncology (ESMO) congress in September 2022, which evaluated the correlation between ETS, DpR, and OS/PFS in patients with wild-type RAS mCRC from the PARADIGM study.
News Results of Knee and Hip Joint Arthroplasty in Hemophiliacs
Total endoprosthesis implantation represents an effective solution for the terminal stages of joint degeneration in hemophiliacs. However, compared to the general population, this group of patients exhibits certain specificities, a higher rate of complications, and historically worse surgical outcomes. Recent studies show that with advancements in surgical techniques, implants, and perioperative care, the results are approaching those of the population without a history of bleeding disorders.
News Options for Prevention and Treatment of Infantile Colic – A Systematic Review of Studies
The authors of the cited literature review evaluated evidence of the benefits of various preventive and therapeutic options for infantile colic. Administering probiotics appears to be a promising therapeutic strategy.
News Mass in the Left Atrium Appendage - Case Report
A symptomatic mass in the left atrial appendage warrants thorough investigation and radical treatment – unless it is in the heart of a polymorbid patient, as was the case in the following report.
News Von Willebrand Disease as a Cause of Abnormal Uterine Bleeding
Abnormal uterine bleeding constitutes a large portion of complaints among women of reproductive age. This type of bleeding is typical for von Willebrand disease (vWD), but also for other types of coagulation disorders. So, is vWD more frequent in women with abnormal uterine bleeding than in the general population?
News 48 Tablets of Teriflunomide? Nothing Should Be Overdone! − Case Study
A case study published in the Journal of Clinical Pharmacy and Therapeutics describes an overdose of teriflunomide, specifically the ingestion of 672 mg of this drug. What measures did the doctors take with the patient? And were they able to prevent serious consequences?
News Primum non nocere applies not only in medicine: an ecological look at inhalers
According to estimates from the World Health Organization (WHO), around 65 million people worldwide suffer from mild to moderate forms of chronic obstructive pulmonary disease (COPD). The cornerstone of therapy is the inhalation administration of bronchodilator drugs. While there is no doubt that this therapy helps patients, what impact do the propellants in inhalation systems have on the global climate? And is there a sensible solution to this problem?
News Current NCCN Recommendations for CLL/SLL Diagnosis – Version 1.2023
In August 2022, the latest guidelines from the National Comprehensive Cancer Network (NCCN) concerning chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) were published. Here we present the essential extract from these recommendations for diagnosing both diseases.
News Inhibition of Sclerostin in Osteoporosis Therapy
Romosozumab, a subcutaneously administered antibody against sclerostin, is one of the most potent osteoanabolics and appears to be a highly effective modality in the treatment of postmenopausal women's osteoporosis. Essential information about the mechanism of action, insights from completed pivotal studies, and practical recommendations for romosozumab treatment are summarized in the following brief overview.
News Extract of Medical Cannabis Now Available for Czech Patients. What Benefits Does It Bring?
At the end of 2022, a new drug based on cannabis extract Naxiva Panaxol by Neuraxpharm was approved in the Czech Republic. It can be prescribed by specialists treating patients with chronic intractable pain. The treatment is covered by public health insurance.
News Oral Azacitidine After Achieving Remission in AML Improves Survival and Does Not Worsen Quality of Life
Orally administered azacitidine as maintenance therapy in patients with acute myeloid leukemia (AML) after achieving remission provides a favorable effect in terms of fatigue and improving health-related quality of life (HRQoL). This is based on the results of the QUAZAR AML-001 study, which were published in the journal Haematologica.