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News Efficacy of L. reuteri DSM 17938 in Treating Acute Gastroenteritis in Children

Diarrheal diseases are among the most common causes of death worldwide in children under 5 years of age. Effective and timely treatment is crucial in the case of acute gastroenteritis (AGE), which is why probiotics are attracting significant attention in the context of AGE therapy. A meta-analysis published last year in the journal Nutrients focused on the efficacy of Lactobacillus reuteri DSM 17938 in treating AGE in children from 3 months to 5 years old.

Source: GI, colic and microbiome 15. 7. 2020

News Lurasidone in a Patient with Paranoid Schizophrenia and Asperger's Syndrome –⁠ A Case Study

Lurasidone is an effective and very gentle antipsychotic which is establishing a prominent position in modern psychopharmacotherapy. Its unique receptor profile makes it a suitable choice for hyperprolactinemia induced by risperidone. A significant benefit of lurasidone is its favorable cardiometabolic profile. Switching from another antipsychotic to lurasidone can be performed on an outpatient basis. Most importantly, it is essential to highlight its effect on both positive and negative symptoms of schizophrenia, as demonstrated by the presented case study.

Source: Modern Treatment of Schizophrenia 27. 2. 2024

News Beta-blockers in the treatment of chronic heart failure: How did the analysis of the effects of 4 drugs in 26 studies turn out?

As a cornerstone of therapy for chronic heart failure with reduced ejection fraction (HFrEF), it is recommended to start treatment with a very low dose of beta-blockers (BB) and titrate it to the maximum tolerated dose. However, it remains unclear whether one BB is superior to others. For this reason, a comprehensive pooled analysis of the efficacy and safety of bisoprolol, carvedilol, nebivolol, and metoprolol in 26 studies, including 14 randomized controlled and 12 observational, was recently published.

Source: Cardiovascular Continuum 28. 3. 2023

News ESC 2022: What Current Insights Say About the Role of Dabigatran in Stroke Prevention with Atrial Fibrillation and Comorbidities

The risk of atrial fibrillation (AF) increases with age as risk factors accumulate and comorbidities arise. What do current data from randomized clinical trials and registries show about stroke prevention (SP) in the context of concurrent AF and some other chronic diseases? This was the focus of one of the symposia at this year's European Society of Cardiology (ESC) Congress.

Source: Anticoagulant Treatment 13. 10. 2022

Články časopisu RADICAL SURGICAL TREATMENT OF HIDRADENITIS SUPPURATIVA OF PENIS AND SCROTUM

Author of the article: Milan Hora, Michal Sviták, Vlastimil Bursa, Petr Stránský, Viktor Eret, Tomáš Ürge, Ondřej Hes, Denisa Kacerovská, Karel Pizinger Source: Česká urologie | 4/2011 14. 11. 2011

News Asthma is not a risk factor for a severe course of COVID-19

According to the statement of the Czech Initiative for Asthma from April 2020, the disease COVID-19 caused by the new type of coronavirus does not pose significantly greater danger for people with asthma than for the general population. It is, however, necessary to adhere to the prescribed treatment and keep asthma under control. The Journal of Allergy and Clinical Immunology provides an explanation for this surprising phenomenon. It is the reduced expression of ACE2 receptors in people with asthma and allergies, as shown by a new study involving three cohorts of pediatric and adult patients. The SARS-CoV-2 virus uses ACE2 receptors to enter the host cell.

Source: Asthma under control 12. 6. 2020

News Nasal Smear as a Modern and Gentle Diagnostic Method for Allergic Rhinitis

Up to 130 million Europeans suffer from allergic rhinitis. Until now, standard diagnostic methods have been skin prick tests and laboratory blood tests. Both methods, however, present significant discomfort for many patients, and skin prick tests can also yield false-positive results. That's why researchers are focusing on new diagnostic possibilities for allergic rhinitis.

Source: Allergic Reactions 14. 10. 2021

News Through Obstacles to the Stars –⁠ Path to Developing a Healthy Gut Microbiota in Children: What Blocks It and What Helps?

The gut microbiota is acquired by an individual during the first 2 years of life. The main source is the mother’s microbiota. Obstacles to the formation of an adequate microbiota include inappropriate composition of the mother’s microbiota, absence of vaginal birth and breastfeeding, as well as artificial feeding and antibiotic treatment in the child. We provide a summary of current findings on the adverse effects of planned cesarean sections on the child’s microbiome, as recently published in Critical Reviews in Microbiology.

Source: GI, colic and microbiome 21. 4. 2020

News The Benefit of Liposomal Irinotecan in the Treatment of Pancreatic Cancer in a Young Patient –⁠ A Case Study

Pancreatic tumors continue to be a challenge in modern oncology. Due to the asymptomatic nature of early stages, most cases are diagnosed in advanced stages. The five-year survival rate of patients does not even reach 10%, and up to half of patients with metastatic pancreatic cancer never make it to the second line of systemic therapy due to the rapid deterioration of their overall clinical condition. In a case study from her own practice, Dr. Marie Beneš Kočová from the Oncology Department of České Budějovice Hospital shared her experience with the treatment of a relatively early-detected disease in a young patient.

Source: Treatment of Gastrointestinal Carcinomas 9. 9. 2024

Články časopisu Hereditary angioedema in gravidity

Author of the article: MUDr. Barbora Kuřecová, MUDr. Petr Janků, prof. MUDr. Jiří Litzman, CSc. Source: Praktická gynekologie | 2/2006 13. 4. 2006

News Fresh from ASH 2021: Promising results of the combination of azacitidine with venetoclax and magrolimab in the treatment of AML

Dr. Naval Daver and his colleagues from the Anderson Cancer Center in Houston presented an oral report during the December congress of the American Society of Hematology (ASH 2021) about a phase Ib/II study that evaluated the effects of the combination of azacitidine (AZA) + venetoclax (VEN) + magrolimab (magro) in various types of patients with acute myeloid leukemia (AML) –⁠ newly diagnosed in older or unfit individuals, high-risk, or relapsed/refractory cases (R/R AML).

Source: Chronic Lymphocytic Leukemia 17. 2. 2022

News Adding Paracetamol to Tramadol to Relieve Early Postoperative Pain After Lumbar Discectomy

A recently published study is likely the first prospective randomized controlled trial comparing the postoperative analgesic efficacy of a tramadol and paracetamol combination versus tramadol alone. Its results favor the combination, with significantly lower pain scores during the first 30 minutes and reduced tramadol consumption within the first 24 hours post-surgery.

Source: Pharmacotherapy of Pain 4. 12. 2020

News How and How the Czech National Hemophilia Program Benefits Professionals and Patients

The Czech National Hemophilia Program (ČNHP) has been an interdisciplinary initiative for many years, coordinating specialized care for both pediatric and adult patients with hemophilia and other congenital bleeding disorders in the Czech Republic. It was established on the platform of collaboration among experts from hematology centers that deal with this issue and is guided by the ČNHP Declaration, which is published on the association's website (see www.cnhp.cz).

Source: Von Willebrand Disease 25. 2. 2022

News Ixekizumab is a Safe Option for Long-Term Treatment of Inflammatory Diseases

Psoriasis, psoriatic arthritis (PsA), and axial spondyloarthritis (SpA) are chronic inflammatory diseases that often require long-term treatment. The current pharmacotherapy of these diseases includes conventional synthetic disease-modifying antirheumatic drugs (DMARDs) and targeted biological therapies that inhibit the effects of tumor necrosis factor (TNF) or interleukins IL-23 and IL-17. An analysis published in early 2020 in the journal Rheumatology focused on the safety of long-term inhibition of IL-17A using ixekizumab.

Source: Biological Treatment 26. 10. 2020

Články časopisu How prevalent is being born small for gestational age? Analysis of 7341 children from the ELSPAC study population

Author of the article: D. Novotná, P. Okrajek, Z. Doležel, L. Kukla, J. Lebl Source: Česko-slovenská pediatrie | 2/2011 25. 2. 2011