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News What Effect Can Be Expected from Limosilactobacillus reuteri in Mucositis and Peri-Implantitis?
A Spanish clinical study monitored the effect of administering probiotics as an adjunct therapy to non-surgical mechanical treatment of peri-implantitis. What did the study show regarding the effect on microbiome composition and overall clinical picture when a preparation containing Limosilactobacillus reuteri Prodentis was administered?
News Central European Expert Consensus on the Treatment of ITP in Adult Patients
In a recently published consensus, experts from Central Europe evaluate the current treatment options for immune thrombocytopenia (ITP) in adult patients and issue 7 recommendations for the administration of thrombopoietin receptor agonists (TPO-RA) in the 2nd line treatment of ITP, based on an analysis of 31 randomized controlled trials.
News Can the Use of Statins Help Reduce the Risk of Dementia?
A meta-analysis published last year by Taiwanese experts evaluated the connection between the use of statins and the incidence of dementia. What conclusions did the authors reach?
News Compression Therapy with Zinc Oxide Dressings in Dermatology
Zinc oxide dressings have a long-standing tradition and continue to find their place in modern dermatology. Compression therapy is the cornerstone of conservative treatment for chronic venous insufficiency and lymphatic insufficiency and should not be overlooked even at the stage of venous leg ulcers.
News Balance and Rehabilitation – Firm on the Ground Even with Multiple Sclerosis
A large portion of patients with multiple sclerosis (MS) suffer from balance disorders. What are the options for non-pharmacological therapy for these issues according to the latest studies?
News Current View on Gestational Diabetes Mellitus in Theory and Practice
We dedicated one of the episodes of our podcast meditalks+ to the issue of gestational diabetes mellitus (GDM), focusing on aspects of care related to general practitioners. In a conversation with Associate Professor MUDr. Ludmila Brunerová, Ph.D., from the Diabetology Center at the Faculty Hospital Královské Vinohrady in Prague, we now continue with a more detailed look at selected questions that will also interest specialists.
News Fatigue as a Significant Symptom of Immune Thrombocytopenia from the Patients' Perspective
The I-WISh survey assessed the impact of immune thrombocytopenia (ITP) and its treatment on patients' lives. Patients identified fatigue as the most frequent, severe, and persistent symptom associated with ITP, unlike doctors who did not attribute such significance to this symptom. Recently published survey results also showed that patients need support from multiple sources, including doctors, family, friends, and patient groups.
News Meta-Analysis of the Results of Studies Comparing the Effectiveness of Manual and Sonic Toothbrushes
Brushing teeth is a fundamental means of maintaining good oral hygiene. While many people still rely on using manual toothbrushes, brushing with electric toothbrushes has also gradually gained significant popularity. Several studies comparing the effectiveness and gentleness of these two approaches have been conducted in the past, followed by a meta-analysis of their results.
News INFOGRAPHIC: Which treatment to choose in the 1st line for a patient with type 2 diabetes?
Diabetes mellitus is a complex chronic disease that requires continuous treatment and a strategy to reduce associated risks beyond mere glycemic control. Comorbidities and the risk of complications are key elements in deciding the choice of therapy for type 2 diabetics. This fact is also considered by the American Diabetes Association (ADA) in its annually published standards of care for patients with diabetes, which brought several changes in 2022.
News Stabilization of Liver Metastases of CRC with Trifluridine/Tipiracil in 3rd Line Therapy – Case Study
We present a case study of a man born in 1944 who underwent resection of the rectosigmoid for multiple adenocarcinomas in February 2016. Subsequently discovered liver metastases were managed with several lines of palliative therapy in combination with repeated surgical resections. Trifluridine/tipiracil administered in the 3rd line represents a well-tolerated oral treatment for this patient, on which he achieved disease stabilization.
News When to Switch to Second-Line Treatment for Primary Biliary Cholangitis?
In patients with primary biliary cholangitis (PBC), the response to ursodeoxycholic acid (UDCA) treatment is an important prognostic indicator. To identify patients with an insufficient response to this modality who require second-line therapy, the best practice is to assess the biochemical response to UDCA after 12 months of treatment. A validated and easy-to-use tool is the determination of serum alkaline phosphatase (ALP) activity and serum total bilirubin concentration. Although treatment response to UDCA is commonly checked after 12 months, a 6-month check has the same discriminatory value.
News Europe and Tooth Decay: The Situation is Improving Thanks to Fluorides and New Technologies
How to prevent tooth decay? This question has been addressed by doctors for several centuries. A major breakthrough occurred in the 1960s when the effect of fluorides was discovered. However, the positive trend later stalled. Why is this and what are the other avenues in modern oral health care?
News Should We Test for Alpha-1-Antitrypsin in All COPD Patients?
Approximately 1–2% of patients with chronic obstructive pulmonary disease (COPD) have an alpha-1-antitrypsin (AAT) deficiency. This is an underdiagnosed genetic disorder that leads to rapid progression of COPD, although it is initially amenable to therapeutic intervention. Therefore, it is necessary to improve early detection of affected individuals. General practitioners can play a crucial role in this process.
News How to Dose Beta-Blockers After Myocardial Infarction?
In patients after myocardial infarction (MI), there is a frequent administration of too low doses of beta-blockers (BB) and rare upward titration of their dose after discharge from the hospital. The SWEDEHEART study investigated to what extent the BB dose actually affects 5-year cardiovascular (CV) outcomes, and data from the American registry allowed a focus on mortality after MI depending on BB dosing.
News Prof. Miloš Broďák: Introduction of new drugs has significantly improved results even in progressive and recurrent prostate cancers
The prognosis and treatment outcomes for patients with various stages of prostate cancer have significantly improved over the past two decades thanks to a number of new or improved modalities of diagnosis and therapy. We should soon benefit from newly introduced screening, or early detection programs, for these tumors. We briefly speak with Prof. MUDr. Miloš Broďák, Ph.D., head of the Urology Clinic of the Medical Faculty of Charles University and University Hospital Hradec Králové, about the latest advancements and challenges in this field, and comprehensively summarize the current options and procedures available today.
News Augmentation of Clozapine with Lurasidone in Resistant Schizophrenia in Real Practice
Treatment-resistant schizophrenia remains a clinical and pharmacological challenge. Clozapine remains the gold standard in these cases. Unfortunately, a significant portion of patients respond only partially to it. The solution is often an augmentation strategy with another atypical antipsychotic. According to current findings, adjunctive therapy with lurasidone appears promising — two recently published studies have brought interesting data.
News Is the efficacy of bisoprolol in secondary prevention of acute myocardial infarction in patients after percutaneous coronary intervention comparable to carvedilol?
Beta-blockers (BB) are recommended for all patients after percutaneous coronary intervention (PCI) as part of secondary prevention of acute myocardial infarction (AMI). The study presented below compared the efficacy of carvedilol – a vasodilating beta-blocker, whose benefit in this indication was confirmed by a randomized clinical trial – with the effect of bisoprolol.
News Dressing Solutions for Better Wound Care
Although wounds at different stages of healing require different types of treatment, the essential part of any dressing change is cleaning the wound and its surroundings from tissue debris and microorganisms and protecting it from reinfection. Modern dressing solutions facilitate easy cleaning and moisturizing of wounds. Effective treatment also brings clinical and economic benefits.
News Recurring allergy symptoms after waking up? It could be due to dust mites
Allergens that are part of the feces and exoskeleton of dust mites, invisible members of human households, can cause milder symptoms like mucosal swelling, itching of the nose or throat, but also a stronger immune reaction, asthma, or severe allergic rhinitis. It is stated that 1−2% of the global population suffers from dust mite allergy, which corresponds to 65−130 million people. Why does it arise and what can be done in its prevention and treatment?
News Myasthenia Gravis and Unmet Patient Needs – Data from Clinical Practice
Myasthenia gravis (MG) is a rare, chronic, disabling, unpredictable, and potentially life-threatening autoimmune neuromuscular disease. There is still a lack of sufficient data from real clinical practice to better meet the needs of MG patients. What is the current situation in European countries? And how are Czech patients doing?
News Ketogenic diet in MS patients as an aid to increase microbiota diversity and quantity
A recent study published in the journal Frontiers in Microbiology explores the role of gut microbiota in multiple sclerosis, specifically the changes in its quantity and the potential for influencing microbiota through a ketogenic diet.
News Magnetic Resonance Can Reduce the Need for Prostate Biopsies
As early as 2013, Czech experts demonstrated that in patients with elevated prostate-specific antigen (PSA) levels, imaging using a 3-Tesla magnetic resonance (3T MRI) can replace biopsy in many cases when detecting prostate cancer.
News With Prof. Pavel Žák about Current Trends and Future Perspectives in Bone Marrow Transplantation and the Role of Carmustine in this Context
Hematopoietic stem cell transplantation has an indispensable place in the treatment of hemato-oncological diseases. We discuss current trends in this area, the significance and benefits of carmustine, the choice between BEAM and TEAM regimens, and the future of bone marrow transplantation in the context of new technologies with the head of the 4th Department of Hematology of the Faculty of Medicine, Charles University and University Hospital Hradec Králové, Prof. MUDr. Pavel Žák, Ph.D.