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News Updated Recommendations of the European Society of Cardiology for the Treatment of HCM
Newly published guidelines by the European Society of Cardiology (ESC) bring several updates in the care of patients with cardiomyopathies. In the following excerpt, we focus on new recommendations for the pharmacotherapy of hypertrophic cardiomyopathy (HCM) in the case of left ventricular outflow tract obstruction (LVOTO).
News What Benefits Does the Fixed Combination of Candesartan/Amlodipine Bring?
A relatively new fixed combination used in the treatment of hypertension is represented by candesartan/amlodipine, that is, a sartan and a calcium channel blocker. Its advantage compared to the combination of ACE inhibitor/calcium channel blocker is primarily the lower occurrence of side effects.
News Current Therapy Options for Interstitial Lung Diseases
Interstitial lung diseases (ILDs) represent a heterogeneous group of disorders characterized by inflammatory or fibrotic changes in the lung parenchyma. Simply put, they can be divided into inflammatory and fibrotic, with inflammatory ILDs often progressing to a fibrotic stage. Interstitial lung diseases are also associated with high morbidity and early mortality. The following text briefly summarizes the current recommendations regarding the therapy for these diseases.
News Importance of pH in Care for Stoma Patients
Maintaining good quality peristomal skin and preventing complications related to the stoma site are integral parts of comprehensive care for patients with stomas. The pH of the skin also plays an important role in this issue, as it can significantly affect the condition of the skin, the development of complications, the quality of life of patients, and consequently impact the economic aspect of stoma care.
News EULAR 2023: What Do CRP Levels Reveal About the Efficacy and Safety of Tofacitinib in Patients with Ankylosing Spondylitis?
What is the impact of baseline C-reactive protein (CRP) levels on the efficacy and safety of treating ankylosing spondylitis (AS) with the Janus kinase inhibitor (JAKi) tofacitinib? The authors of the cited study below sought to answer this question, with their results presented at this year’s annual EULAR congress, which took place in Milan, Italy, at the traditional turn of May and June.
News Non-Steroidal Anti-Inflammatory Drugs in the Treatment of Ankylosing Spondylitis: Network Meta-Analysis
A literature review and network meta-analysis of randomized controlled trials published in the journal Experimental and Therapeutic Medicine demonstrates the high efficacy and good tolerability of 6 non-steroidal anti-inflammatory drugs (NSAIDs) including etoricoxib, celecoxib, meloxicam, diclofenac, naproxen, and ß-D-mannuronic acid in the treatment of ankylosing spondylitis (AS).
News Minimum and Optimal Factor Levels in Physically Active Hemophiliacs
Authors of a recently published study attempted to determine the value of minimum and optimal levels of coagulation factors in patients with severe hemophilia who engage in physical activities.
News Recommendations for Substitution Therapy with Immunoglobulins in Hemato-oncological Patients with Secondary Immunodeficiency – Expert Consensus According to the DELPHI Methodology
Substitution therapy with immunoglobulins is used not only for patients with primary immunodeficiencies. Below, we briefly summarize recommendations concerning hemato-oncological patients with secondary immunodeficiency.
News Prevalence of Depression, Anxiety, and Stress in the Global Population During the COVID-19 Pandemic
A cross-sectional study assessed the prevalence and rate of depression, anxiety, and stress among individuals from various countries around the world during the ongoing COVID-19 pandemic and initial measures to combat the spread of the infection. The impacts on individual subgroups of the population were also analyzed.
News How Common is Alpha-1 Antitrypsin Deficiency?
What is the prevalence of alpha-1 antitrypsin deficiency (AATD)? What comorbidities are associated with it? Are healthcare costs for these patients higher compared to patients with unrelated obstructive lung diseases? Awareness of AATD is low and prevalence data are only indicative. The authors of a study published in the European Respiratory Journal aimed to map this disease in a population of 4 million German insured individuals.
News Noonan Syndrome (Not Just) in the Pediatric Cardiologist's Office
Noonan Syndrome (NS) is a genetically determined disease associated with a high prevalence of (not just) congenital heart defects. When is it necessary to consider it in a cardiologist's office, where to refer the patient if suspected, and how to proceed if the diagnosis is confirmed?
News Streptococcus pneumoniae Serotype 3 Continues to Be the Most Frequent Cause of Invasive Pneumococcal Diseases in the Czech Republic
After 2 years influenced by the COVID-19 pandemic, the number of cases of invasive pneumococcal diseases (IPD) has returned to pre-2020 levels. Serotype 3 remains the most frequent cause of IPD for the twelfth consecutive year.
News Current and Future Possibilities for Influencing Immune Thrombocytopenia
The possibilities for treating immune thrombocytopenia (ITP) are quite broad today, with a major advancement for many patients being the advent of thrombopoietin receptor agonists. However, for some patients, optimal treatment is still not available, and their hope lies in further research.
News Fixed combination tiotropium/olodaterol in regular clinical practice: What do patients say?
A non-interventional international study assessed the therapeutic benefits of the fixed combination of tiotropium/olodaterol in the treatment of chronic obstructive pulmonary disease (COPD) in real-world practice through a questionnaire filled out by patients.
News Mechanism of Action of Venopharmaceuticals and Their Use in the Treatment of Chronic Venous Insufficiency
Venopharmaceuticals are the cornerstone of conservative treatment for chronic venous insufficiency (CVD). Their mechanism of action is complex and not yet fully understood. They act on both micro - and macrocirculation, influence the tone of the venous wall, and their anti-inflammatory action is also significant.
News Perioperative Management of Bleeding in Patients with von Willebrand Disease Using Coagulation Factors
Von Willebrand disease is one of the most common congenital bleeding disorders. It is a heterogeneous group of diseases with varying severity of clinical manifestations. Some patients require pharmacological prevention or treatment of bleeding as part of perioperative care. The administration of concentrates containing coagulation factors is currently the gold standard for certain types of von Willebrand disease.
News Safety of Long-Term Therapy with Bevacizumab in Oncological Patients
The angiogenesis inhibitor bevacizumab is typically administered long-term. Therefore, a study published in the journal The Oncologist deals specifically with its long-term safety and tolerability in patients with various types of solid tumors.
News Fixed Combination of Tramadol/Paracetamol in the Treatment of Chronic Lower Back Pain and Its Effect on Apathy in Chronically Algic Patients
Long-term chronic pain is associated with apathy, loss of motivation, and depression in patients. However, these comorbidities of chronic pain and their interconnections are still insufficiently explored. The aim of the Japanese study was to evaluate the prevalence of apathy in patients with chronic low back pain (LBP) and the therapeutic efficacy of the fixed combination of tramadol/paracetamol in treating this pain and its effect on apathy in LBP patients.
News Intravenous Thrombolysis in Ischemic Stroke Patients on Dabigatran Treatment
What are the outcomes of performing intravenous thrombolysis in patients with acute ischemic stroke after reversing the anticoagulant effect of dabigatran with idarucizumab? The answer is provided by a data analysis from real-world clinical practice in stroke centers, published by Czech authors.
News News in COPD Treatment Recommendations in a Nutshell
We present an overview of the most important changes in the annually updated recommendations of the Global Initiative for Chronic Obstructive Lung Disease (GOLD).