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News Subcutaneous Immunoglobulin Therapy in Patients with Secondary Immunodeficiency –⁠ Real-World Data

Even in patients with secondary immunodeficiency (SID), immunoglobulin substitution can be indicated. Intravenous (IVIG) therapy is considered effective based on studies, but subcutaneous (SCIG) therapy is only based on experiences with patients having primary immunodeficiency (PID). The Italian study presented below, therefore, investigated the efficacy and safety of SCIG in patients with SID.

Source: Primary and Secondary Immunodeficiencies 2. 10. 2023

Články časopisu Implementation and applications of robotic surgery within gynecologic oncology and gynecology; analysis of the first thousand cases

Author of the article: C. Lönnerfors, J. Persson Source: Česká gynekologie | 1/2013 1. 3. 2013

News Could candesartan counteract adverse intestinal changes induced by hypertension?

An experimental study published last year was the first to show that administration of candesartan may increase the tightness of epithelial junctions in the intestinal wall and positively affect the composition of the microflora. It expands the knowledge of recently described pathophysiological changes in the gut associated with hypertension.

Source: Sartans in the Treatment of Hypertension 6. 3. 2020

News Improving treatment outcomes of HF with preserved ejection fraction according to JACC: What does the success of gliflozins mean for the future?

The Journal of the American College of Cardiology (JACC) recently issued a scientific statement in which the authors thoroughly examined current knowledge on the epidemiology, pathophysiology, diagnosis, and treatment of heart failure with preserved ejection fraction of the left ventricle (HFpEF). Recent studies in this heterogeneous disease suggest the importance of carefully determining the HFpEF phenotype in a given patient based on pathophysiology, which enables better individualization of treatment. The authors also reflect on the success of gliflozins in treating HFpEF and how HFpEF pharmacotherapy can be further improved.

Source: Heart Failure 4. 3. 2024

News Safety and Efficacy of Combination Therapy for Allergic Rhinitis Compared to Monotherapies and Placebo

Combination therapy of antihistamine and corticosteroid is a promising alternative for patients suffering from seasonal allergic rhinitis. A phase II clinical study aimed to determine the effective dosage, efficiency, and safety of combination therapy compared to monotherapies and placebo.

Source: Life Without Allergic Rhinitis 7. 6. 2022

News Prenatal Phenotype of Children with Noonan Syndrome

Until recently, the various phenotypes of RASopathies were clinically diagnosed only after birth. However, we are now striving for the earliest possible diagnosis, sometimes even prenatally. Ultrasound examination of the fetus during screening tests, focusing on certain characteristic morphological changes, plays a crucial role in this. In the case of pathological findings on imaging methods, molecular genetic testing and monitoring of pregnancy in specialized centers are indicated.

Source: Growth Disorders 4. 5. 2021

News Will 3D Printable Tissue Adhesives Replace Stitches and Clips?

3D printing technology is slowly making its way into more and more areas of healthcare. In February 2024, a scientific team from the Massachusetts Institute of Technology (MIT) published a study in the journal Nature Communications focusing on the possibilities of 3D printing tissue adhesives and personalized patches with adjustable internal structures. These could therefore become a suitable alternative to the traditional surgical sutures and clips used for joining tissues.

Source: 8. 5. 2024

Články časopisu Fertility preserving methods in women with breast cancer before gonadotoxic therapy

Author of the article: N. Halászová, I. Crha, Martin Huser, Vít Weinberger, J. Žáková, M. Ješeta, E. Lousová, E. Filipinská, P. Ventruba Source: Česká gynekologie | 4/2017 15. 9. 2017

News Doc. Miloslav Salavec: We Still Encounter Delayed Initiation of Biological Treatment in AD and Many Other Diagnoses

Not all patients with atopic dermatitis (AD) who are indicated for biological treatment with dupilumab manage to reach centers where the treatment is provided. It's even more unfortunate when there's ample evidence that the effects of this therapy on disease manifestations and overall quality of life extend beyond just the patients. It also impacts the lives of their close ones who care for those with atopic dermatitis. Head of the Clinic of Venereal and Skin Diseases at Charles University and the University Hospital Hradec Králové Doc. MUDr. Miloslav Salavec, CSc., evaluates how dupilumab has performed over several years of real clinical practice and the specific benefits it has brought to patients.

Source: Systemic treatment of atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyposis – Type 2 inflammation 4. 12. 2023

News Artificial Intelligence Helps in Selecting Influenza Strains for Vaccine Production

Vaccination is one of the most important and effective preventive measures in the fight against seasonal epidemics caused by influenza viruses each year. For vaccines to work, they must match the currently circulating influenza strains. The timely selection of appropriate influenza strains, which will be the most widespread in the population in the upcoming period, and their yield are crucial for vaccine development. The new MAIVeSS (Machine-learning Assisted Influenza Vaccine Strain Selection) method, which uses artificial intelligence and machine learning algorithms for direct analysis of clinical samples, could help with this process.

Source: 17. 4. 2024

News Overall Survival in Patients with Metastatic CRC During 1st-Line Anti-EGFR Treatment Depending on the Presence or Absence of Hypomagnesemia

Hypomagnesemia is one of the side effects of monoclonal antibody therapy against the epidermal growth factor receptor (EGFR). The study presented below examined overall survival in patients with metastatic primarily unresectable colorectal cancer (CRC) treated with anti-EGFR therapy depending on the presence or absence of hypomagnesemia.

Source: Colorectal Cancer 3. 10. 2022

News Potential of Aloe to Reduce Severity of Symptoms in Patients with IBS −⁠ What Emerged from the Analysis of Fecal Microflora and Metabolite Profiles?

Current treatment options for irritable bowel syndrome (IBS −⁠ irritable bowel syndrome) are relatively limited. This increases interest in complementary and alternative therapy options with plant preparations. One modality used to alleviate IBS symptoms is Aloe barbadensis Mill. The aim of a clinical study by Swedish researchers was to assess the effect of aloe on IBS symptoms compared to a control treatment with inulin.

Source: Irritable Bowel Syndrome 12. 11. 2022

News Extract from Aloe barbadensis in the Treatment of Irritable Bowel Syndrome

The authors of a pooled analysis of two randomized controlled trials evaluated whether administration of Aloe barbadensis extract in patients with diarrhea-predominant irritable bowel syndrome (IBS) resulted in a significant reduction in the overall severity of symptoms.

Source: Irritable Bowel Syndrome 29. 4. 2022

News How do body weight and metabolic parameters change in patients first hospitalized for psychosis?

The most common cause of death in patients with schizophrenia is cardiovascular disease, which is closely related to obesity or metabolic syndrome. The study presented below examined changes in body weight and metabolic parameters during the first hospitalization of these patients.

Source: Modern Treatment of Schizophrenia 24. 11. 2023

News Is Obesity a Universal Phenotype in Children with Type 2 Diabetes?

What is the global prevalence of obesity in children and adolescents suffering from type 2 diabetes mellitus (T2DM)? Does the occurrence of obesity in pediatric T2DM correlate with gender or race? And how is obesity in T2DM under 18 years of age associated with glycemic control and dyslipidemia? These questions have been addressed by Canadian authors in their recently published systematic review and meta-analysis, which deals with various issues related to childhood obesity.

Source: Modern Treatment of Diabetes 19. 4. 2023