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News Effect of Nuclear Magnetic Resonance Therapy in Patients with Osteoarthritis
Osteoarthritis represents the most common joint disease in adults, with its incidence and prevalence increasing with age. With the overall aging of the population, it is becoming a significant medical as well as social problem. Due to the growing number of cases, new modalities are being sought for current therapeutic procedures, including nuclear magnetic resonance therapy, whose effect has been verified by an extensive clinical study.
News Diagnosis of AAT Deficiency According to Italian Recommendations and a Clear Algorithm for Practice
Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder that primarily affects the lungs and liver. It is considered a rare disease, but it is also significantly underdiagnosed. Given the availability of specific treatment, which involves the administration of purified alpha-1 antitrypsin (AAT) derived from human plasma in patients with COPD due to AATD, identifying these patients is crucial. We summarize the recently issued Italian recommendations for the diagnosis of AATD and place them in the context of Czech standards.
News Effect of Azacitidine in the Treatment of Acute Myeloid Leukemia on Long-Term Patient Survival
The work cited below presents freshly updated results from the Quazar AML-001 study evaluating azacitidine (AZA) in the treatment of acute myeloid leukemia (AML), now with a median follow-up period of 55.5 months. Among other things, clinical and biological variables predictive of long-term survival, defined here as survival ≥ 3 years from randomization within the study, were examined.
News Brigatinib in the Therapy of Pretreated Patients with Advanced ALK-Positive NSCLC
A French study analyzed clinical data of pretreated ALK-positive patients with advanced non-small cell lung cancer (NSCLC) and examined the efficacy of next-generation ALK inhibitors – brigatinib, followed by lorlatinib – in real-world clinical practice.
News EULAR 2023: How does tofacitinib affect cardiovascular risk in rheumatoid arthritis?
At this year's European League Against Rheumatism (EULAR) congress, held at the turn of May and June in Milan, Italy, a study was presented that examined the impact of tofacitinib use on cardiovascular (CV) risk in patients with active rheumatoid arthritis (RA).
News Can antihypertensive treatment also have a beneficial effect on neurocognitive functions?
Observational studies suggest that a desirable side effect of AT1 receptor blockers for angiotensin II (sartans) could be cognitive protection of patients. A randomized study published last year evaluated the potential positive impact of candesartan and lisinopril on neurocognitive functions in older patients with mild cognitive impairment (MCI).
News Water Microjet as a Gentler Method of Debridement
Debridement is an integral part of chronic wound treatment. Currently, the most common method is mechanical debridement, which involves the use of sharp tools or abrasive materials to remove necrotic tissue. However, this method can be painful, imperfect, and associated with the risk of damaging healthy tissue. New and gentler methods are emerging, promising improved therapeutic outcomes, such as the use of a water microjet.
News Pitfalls of Levothyroxine Replacement Therapy
Hypothyroidism (reduced function of the thyroid gland) affects approximately 1-2% of the population. Its prevalence increases with age and it is more common in women. Synthetic thyroid hormone levothyroxine is used to treat hypothyroidism. It is a widely prescribed medication available in tablets of various strengths.
News Early Effect of Once-a-Day Trazodone in the Treatment of Major Depressive Disorder
Most antidepressants have a delayed onset of action, reaching therapeutically effective levels only several weeks after the start of treatment. Trazodone is characterized by a specific mechanism of action and a rapid onset of therapeutic effect. A newly published analysis evaluated the available clinical data regarding the early effect of once-a-day trazodone in patients with Major Depressive Disorder (MDD).
News Monocyte Distribution Width as a New Indicator of Sepsis in High-Risk Patients
Most septic patients are first encountered in the emergency department, where sepsis detection is often delayed, partly due to a lack of effective biomarkers. The study presented below evaluated the diagnostic accuracy of monocyte distribution width in peripheral blood alone and in combination with white blood cell count evaluation for early sepsis detection.
News Efficacy and Safety of Empagliflozin in Patients with Heart Failure with Preserved Ejection Fraction
Previous studies have shown that the antidiabetic drug empagliflozin reduces the risk of cardiovascular death or hospitalization for heart failure in patients with heart failure with reduced left ventricular ejection fraction (HFrEF), both in diabetics and non-diabetics. The aim of the EMPEROR-Preserved clinical trial was to supplement data on the efficacy and safety of empagliflozin in a population of patients with heart failure with preserved ejection fraction (HFpEF; EF LK > 40%).
News Optimization of Enoxaparin Dosing in Obese Patients
Obesity is a risk factor for venous thromboembolism; however, there is uncertainty regarding the optimal dose of enoxaparin for treating acute episodes in the obese population. Two observational studies published last year focused on the efficacy and safety of enoxaparin depending on the dose. The standard dose of 1 mg/kg may be too high for some patients, and fixed dosing without monitoring Xa levels may not be adequate.
News Comprehensive View on Care for Patients with Urostomy
Thanks to improvements in surgical techniques and shorter hospital stays, patients with a stoma are returning to their home environment and to the care of outpatient doctors sooner. Quality care in the postoperative period is a crucial element in the prevention of complications, support of healing, and education of ostomy patients. Doctors caring for these patients should approach them comprehensively, considering all their needs and aspects.
News Liposomal Ozonated Oil in the Treatment of Eye Infections
Liposomal ozonated oil is a new ocular antiseptic with antibacterial, anti-inflammatory, and regenerative properties, making it suitable for the prevention and treatment of eye infections and as an adjuvant in wound healing. In June 2022, Spanish authors published a review summarizing findings on the mechanism of action and results of preclinical and clinical studies with ozonated oil in the treatment of eye infections and in the regeneration of the ocular surface. It also highlights the benefits of ozonated oil compared to conventional antiseptics such as povidone-iodine and chlorhexidine.
News Prof. Petr Marusič: Is the Success of Therapy Changing with the Arrival of New Antiepileptics?
At the XXV. postgraduate course in epileptology, 'Jiří Dolanský Days', prof. MUDr. Petr Marusič, Ph.D., from the Neurological Clinic of the 2nd Faculty of Medicine, Charles University, and Motol University Hospital, lectured on the topic of changes in the efficacy of epilepsy treatment with the arrival of new anti-seizure medications.
News Economic Burden and Loss of Quality of Life as a Consequence of Dry Eye Syndrome
Canadian authors evaluated the direct and indirect financial costs associated with dry eye syndrome (DED − dry eye disease) and the impact of this condition on the quality of life (QoL) of patients. The results were stratified according to the severity of the condition. The most significant was the loss of work productivity, highlighting the need for adequate solutions for DED.
News Impact of Administering Omega-3 Fatty Acids on the Risk of Metabolic Syndrome in Patients with Schizophrenia
The aim of the Polish clinical study OFFER was to assess the possibility of influencing the risk of developing metabolic syndrome (MetS) and some of its individual components in patients with first-episode schizophrenia by supplementing with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).
News Prostate Health Index and its Possible Use in Clinical Practice
With the increasing incidence of prostate cancer, the effort to improve its diagnostics is also growing. The exclusively used and practice-proven prostate-specific antigen (PSA) continues to play an indispensable role in identifying at-risk patients, but some of its isoforms can also provide important information for deciding the patient's further fate. Based on their combination, a so-called prostate health index (PHI) can be determined. A recently published work by Czech authors assessed the usability of PHI as a parameter suitable for evaluating the aggressiveness of prostate cancer (PC) within the PHIMOPLUKTHOM study.
News Geriatrics and Nutrition in Old Age - Invitation
We invite you to watch a webinar dedicated to the topic of nutrition in old age. The impetus for its creation was the fact that from September 1, 2020, physicians specializing in geriatrics are allowed to prescribe outpatient sipping to ensure early nutritional intervention for malnourished patients.
News Fixed combinations of Enerzair® and Atecura® may improve asthma treatment
The newly approved fixed triple combination Enerzair® and the fixed dual combination Atectura® have demonstrated improvements in lung function and a reduction in exacerbations in previously uncontrolled asthma patients. Administering once daily using the Breezhaler® inhaler along with the possibility of connecting a digital aid aims, among other things, to facilitate usage and proper adherence to the treatment.
News Potential, Benefits and Proper Use of Probiotics in the Treatment of Acute Gastroenteritis in Children
Clinical studies and experiences from clinical practice have shown the benefits of administering probiotics in the treatment of acute gastroenteritis in children. Pediatrician Dr. Natália Szitányi summarizes the possibilities and rationale for their use in this indication.
News New Hematological Biomarker for Early Diagnosis of Sepsis
Sepsis is one of the leading causes of mortality and healthcare expenditure worldwide. Early diagnosis and treatment of septic conditions improve patient prognosis. However, the initial symptoms of sepsis can be difficult to distinguish from other acute conditions due to similar symptomatology. The results of the study presented below indicate that a new hematological biomarker has the potential to facilitate the early diagnosis of sepsis.
News Expanded Hemodialysis and Its Impact on Reducing Hospitalization Rates and Medication Usage
The number of patients with end-stage kidney disease is increasing. New approaches and technological advancements in recent decades have contributed to improving hemodialysis treatment. Does the use of so-called expanded hemodialysis lead to better outcomes?