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News Stabilization of Transthyretin and Long-term Survival of Patients with Cardiac Amyloidosis
Tafamidis is used in the therapy of transthyretin amyloid cardiomyopathy (ATTR-CM), which has proven its benefit in the ATTR-ACT clinical study. The results of its open-label extension study show that early diagnosis and prompt initiation of therapy are crucial.
News Prostate Health Index and its Possible Use in Clinical Practice
With the increasing incidence of prostate cancer, the effort to improve its diagnostics is also growing. The exclusively used and practice-proven prostate-specific antigen (PSA) continues to play an indispensable role in identifying at-risk patients, but some of its isoforms can also provide important information for deciding the patient's further fate. Based on their combination, a so-called prostate health index (PHI) can be determined. A recently published work by Czech authors assessed the usability of PHI as a parameter suitable for evaluating the aggressiveness of prostate cancer (PC) within the PHIMOPLUKTHOM study.
News Incidence of Osteoporosis in Patients with Atrial Fibrillation Treated with Different Oral Anticoagulants
Previous research has suggested an increased risk of osteoporosis and osteoporotic fractures in patients with atrial fibrillation treated with warfarin. A recent analysis also identified a higher incidence of osteoporosis in patients treated with warfarin or direct oral anticoagulants (DOACs). However, less is known about the risk of this disease when using DOACs compared to warfarin. Therefore, Australian doctors compared its incidence in patients treated with different oral anticoagulants for atrial fibrillation (AF) in a population cohort study using data from a nationwide primary care database.
News Importance of Home Parenteral Therapy: ESPEN Recommendations from 2020
Home parenteral therapy currently plays a crucial role in the treatment and prevention of malnutrition in specific patient groups. The European Society for Clinical Nutrition and Metabolism (ESPEN) published updated guidelines for home parenteral therapy in 2020, based on current evidence and expert recommendations.
News Dust Mite Allergy and the Risk of Sleep-Disordered Breathing
New York authors in their recently published retrospective analysis tested the hypothesis that individuals with allergic rhinitis caused by dust mite allergy have an increased risk of breathing disorders during the REM phase of sleep, based on objective polysomnography evaluation.
News Results of Long-Term Follow-Up of Patients with Prostate Adenocarcinoma After Radiotherapy with Short-Term Androgen Deprivation
Adding short-term androgen deprivation to radiotherapy improved overall survival, disease-specific mortality, and the incidence of distant metastases in men diagnosed with prostate adenocarcinoma. Subsequent analysis investigated whether the beneficial effect of androgen deprivation is long-lasting.
News INTERACTIVE CASE STUDY of a patient with mCRC treated long-term with various modalities
MUDr. Stanislav John, Ph.D.,
Clinic of Oncology and Radiotherapy, Faculty of Medicine, Charles University and University Hospital Hradec Králové
News Alemtuzumab – Does Age Matter? Or Not?
The authors of a study published this year focused on the safety and efficacy of alemtuzumab in patients with relapsing-remitting multiple sclerosis (RRMS). How did it perform over the observed period in patients of different age categories?
News Subcutaneous pdC1-INH in Patients with Hereditary Angioedema in Real-World Practice
Italian authors published a series of cases of patients with hereditary angioedema caused by C1 inhibitor deficiency (C1-INH-HAE) with long-term prophylaxis using human plasma-derived C1 inhibitor concentrate (pdC1-INH) in subcutaneous form. They supplement the results of the placebo-controlled COMPACT study, in which s.c. pdC1-INH reduced the frequency of attacks, with insights from real-world practice in 5 patients treated at the angioedema therapy center in Milan, Italy.
News Balance and Rehabilitation – Firm on the Ground Even with Multiple Sclerosis
A large portion of patients with multiple sclerosis (MS) suffer from balance disorders. What are the options for non-pharmacological therapy for these issues according to the latest studies?
News Parenteral Nutrition as Part of Cancer Patient Treatment
Malnutrition represents a potentially serious complication for cancer patients. If it is not possible to meet the nutritional demands of the body through the enteral route, parenteral nutrition must be initiated. A doctor will recommend it in situations where the patient is at risk from the consequences of malnutrition. Up to 45% of these patients struggle with at least a 10% loss of their body weight.
News Does Administration of Saline Make a Crucial Difference Compared to Balanced Crystalloids in Critically Ill Patients?
A study published in the New England Journal of Medicine provided data on mortality and deterioration of renal function in adult patients in intensive care units, depending on whether they received saline or balanced crystalloid solutions for fluid replacement.
News Itoprid helps diabetics with reduced gastrointestinal motility improve diabetes control
The prokinetic itoprid led not only to the alleviation of gastroparesis symptoms and an improvement in quality of life in a prospective multicenter observational study on patients with diabetes and reduced gastrointestinal (GI) motility, but also to an improvement in glycemic parameters.
News CASE STUDY: Surgical Procedure in an Adolescent Patient with Severe Hemophilia A on Emicizumab Prophylaxis
This case study is narrated by MUDr. Bohumír Blažek from the Clinic of Pediatric Medicine at LF OU and FN Ostrava. The patient is a 17-year-old boy with severe hemophilia A. Several months prior to the procedure under discussion, he was switched from prophylactic factor VIII administration to emicizumab prophylaxis. Subsequently, an extraction of all four molars was planned for orthodontic reasons. The case study describes the hematologist's approach to the procedure and the subsequent healing process.
News Reasons for Nonadherence to Statin Therapy - Survey Results Among Patients
Adherence to statin therapy remains suboptimal despite its proven benefits in reducing cardiovascular risk in individuals with dyslipidemia. Recently published survey results conducted among patients prescribed statins have identified barriers preventing proper adherence to this treatment.
News Trazodone in the Treatment of Depressive Disorder – A Case Study
Presented by MUDr. Sylva Racková, Ph.D.
Psychiatric Clinic, Plzeň
News Interactive Case Study: AATD – Alpha-1-Antitrypsin Deficiency
We present a case study of a man who was 41 years old at the time of his first contact with a pulmonary doctor. He came with symptoms of allergic seasonal rhinoconjunctivitis, proven sensitivity to spring trees, grasses, and dust mites, otherwise healthy, a parrot breeder. He is a former smoker with a smoking history of 20 pack-years. He was examined for exertional dyspnea, cough, recurrent respiratory infections, and wheezing. Try to follow the further diagnostic procedure and considerations with us, where you can choose between different options. At the same time, you will verify whether you proceeded correctly, along with the justification for the step taken.
News Interactive Case Study: Treatment of Neuropathic Pain in a Patient with Neurodegenerative Disease
We offer a brief case study of a polymorbid patient suffering from chronic pain, spasticity, and sleep disturbances, among other issues. Medical cannabis was advantageously introduced, helping to alleviate several symptoms. You can interactively explore how you would proceed in this case.
News Virtual Echocardiography as a Potential Screening Tool for the Diagnosis of Primary Pulmonary Hypertension
Primary pulmonary hypertension disease is associated with a poor prognosis. Early diagnosis and the implementation of specific therapy are necessary to improve patients' prospects. In the near future, virtual echocardiography, which has shown good results in published studies, may become a valuable screening tool.
News ESC 2022: How to use gliflozins in heart failure? American guidelines now also consider the EMPEROR-Preserved study
One of the important current cardiology topics is the possibility of using gliflozins in patients with chronic heart failure (HF) regardless of the left ventricular ejection fraction (LVEF). The possibilities of introducing these medicines into clinical practice, considering the issue in international guidelines, and the results of empagliflozin in recent studies were covered in a practically oriented symposium as part of the professional program of this year's European Society of Cardiology Congress (ESC 2022).
News Teriflunomide vs. Dimethyl Fumarate in Real Practice: We Know the Winner! Will It Surprise You?
Teriflunomide and dimethyl fumarate are disease-modifying drugs (DMDs) used in the treatment of multiple sclerosis (MS). Regarding the course, form, and severity of MS, their target groups are comparable in their characteristics. These DMDs are therefore ideal candidates for mutual comparison. Swedish authors decided to compare their effectiveness based on data from real clinical practice obtained through the Swedish National Registry.