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News Gliflozins in the Treatment of Type 2 Diabetes According to Current Recommendations SVL
Gliflozins are a relatively new group of antidiabetics with a specific mechanism of action. In addition to glycemic control, they have shown favorable effects on body weight and blood pressure, minimal risk of hypoglycemia, reduced risk of heart failure, and also renal protection and cardiovascular safety. Their position in the therapeutic algorithm for type 2 diabetes is clearly defined in the 2020 recommendations of the Society of General Medicine ČLS JEP.
News Extract from Aloe barbadensis in the Treatment of Irritable Bowel Syndrome
The authors of a pooled analysis of two randomized controlled trials evaluated whether administration of Aloe barbadensis extract in patients with diarrhea-predominant irritable bowel syndrome (IBS) resulted in a significant reduction in the overall severity of symptoms.
News Aloe vera Extract in the Therapy of Irritable Bowel Syndrome
The therapy options for irritable bowel syndrome are relatively limited, thus complementary and alternative treatments besides conventional therapy are applied. Many patients report that using Aloe vera extract helps reduce their disease symptoms, although there is a lack of valid evidence from clinical studies. The pilot study presented below focused on evaluating the efficacy of Aloe vera extract compared to placebo in several dozen patients with irritable bowel syndrome.
News Maintenance Therapy of a Female Patient with AML After Intense Chemotherapy – Case Study
The following case study presents the case of a female patient with acute myeloid leukemia (AML) who experienced life-threatening complications after the second consolidation chemotherapy, rendering her incapable of undergoing further intense therapy or allogeneic HSCT. In this situation, maintenance therapy with oral azacitidine proved beneficial – this modality, due to its good tolerance, can be used as a bridge until allo-HSCT can be performed in patients in poor clinical condition.
News The Importance of Hydration in Wound Healing
In response to skin injury, bodily processes initiate to restore the function of the skin barrier, minimize fluid loss, and ensure optimal hydration. Studies have shown that wounds maintained in a moist or hyperhydrated environment heal faster than those left to dry in the air. Research further suggests that the harmful effects of exudate in poorly healing wounds are not due to the water itself, but to the biological components contained in the exudate.
News After 20 years, a new treatment option for primary biliary cholangitis arrives
Primary biliary cholangitis (PBC), formerly known as cirrhosis, is a rare disease with a negative impact on prognosis and quality of life. While ursodeoxycholic acid (UDCA) has been essentially the only treatment option for PBC so far, in 2016, the European Medicines Agency (EMA) approved obeticholic acid as a second-line option. Since 2019, this medication has been available and fully covered by health insurance in 11 selected centers in the Czech Republic.
News Previous Treatment of Osteoporosis May Affect the Efficacy of Romosozumab
A study conducted by a team of authors from several clinical sites in Japan shows that the type and duration of previous osteoporosis treatment just before starting romosozumab affects its therapeutic effect. Romosozumab, as an antibody targeting sclerostin, stimulates bone formation and suppresses bone resorption. The authors of the study investigated whether the efficacy of 12-month treatment with romosozumab depends on the duration of prior treatment with teriparatide, denosumab, or oral bisphosphonates.
News Can we properly manage osteoporotic fractures?
Osteoporotic fractures are associated with increased morbidity and mortality and often lead to an overall deterioration in the quality of life. We should not forget to diagnose osteoporosis in patients after fractures and subsequently set appropriate therapy.
News Medication in Patients with Myasthenia Gravis – What to Watch Out For?
According to current recommendations, the treatment of myasthenia gravis (MG) should be individualized, considering the severity of the disease, the type of autoantibodies, thymus pathology, and, last but not least, the patient's preferences and comorbidities. What are the usual treatment modalities? What specifics need to be considered when treating comorbidities or acute illnesses in patients with MG? The following text briefly summarizes the answers to these questions.
News MUDr. Libor Dvořáček: Microinvasiveness of surgery involves not only the method but also targeted solutions to varicose vein sources
Varicose veins, or chronic venous insufficiency of the lower extremities, are primarily a health issue, not purely a cosmetic one. This is because they are associated with the risk of complications that necessitate long-term therapy and complex treatment of these issues. As MUDr. Libor Dvořáček, the head physician of the Vasmedic Clinic, mentions in our brief interview on this topic, the approach of health insurance companies and the Ministry of Health has fortunately been changing in favor of day surgery – that is, microinvasive and much gentler surgery.
News Monocyte Distribution Width as a New Indicator of Sepsis in High-Risk Patients
Most septic patients are first encountered in the emergency department, where sepsis detection is often delayed, partly due to a lack of effective biomarkers. The study presented below evaluated the diagnostic accuracy of monocyte distribution width in peripheral blood alone and in combination with white blood cell count evaluation for early sepsis detection.
News Debate on Sepsis Biomarkers 'on Blood'
Sepsis represents a major cause of death from infectious diseases. Early identification of patients with a prognosis of sepsis is therefore crucial for their survival and prognosis. In addition to traditional biomarkers such as C-reactive protein (CRP) or procalcitonin (PCT), other markers are being sought that could be used in the differential diagnosis of sepsis. This issue was also addressed at a symposium organized by Beckmann Coulter, which took place on April 28, 2022, as part of the Colours of Sepsis congress in Ostrava.
News 10 Properties and Benefits of Gliptins: How They Work and When to Prescribe Them
General practitioners can now prescribe oral antidiabetics from the group of gliptins to patients with type 2 diabetes. Their therapeutic options are significantly expanded in the care of these patients. In the following text, we briefly summarize the mechanism of action of gliptins and their advantages over other oral antidiabetics.
News Updated Recommendations of the European Society of Cardiology for the Treatment of HCM
Newly published guidelines by the European Society of Cardiology (ESC) bring several updates in the care of patients with cardiomyopathies. In the following excerpt, we focus on new recommendations for the pharmacotherapy of hypertrophic cardiomyopathy (HCM) in the case of left ventricular outflow tract obstruction (LVOTO).