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News Geriatrics and Nutrition in Old Age -⁠ Invitation

We invite you to watch a webinar dedicated to the topic of nutrition in old age. The impetus for its creation was the fact that from September 1, 2020, physicians specializing in geriatrics are allowed to prescribe outpatient sipping to ensure early nutritional intervention for malnourished patients.

Source: Enteral Nutrition 19. 11. 2020

News Current ASH Guidelines for Management of ITP 2019 −⁠ Recommendations for Newly Diagnosed ITP in Adults

The American Society of Hematology (ASH) published current guidelines for immune thrombocytopenia (ITP) at the end of 2019, where a panel of experts attempted to define evidence-based recommendations for the management of these patients.

Source: Immune Thrombocytopenia 20. 2. 2020

News Efficacy and Safety of Enoxaparin in Hospitalized Patients with Severe Renal Insufficiency

A study evaluating the effect of thromboprophylaxis with enoxaparin at a dose of 20 mg/day in adult patients with renal failure compared the incidence of venous thromboembolism (VTE) with published results in patients without renal insufficiency who were prophylactically treated with enoxaparin at a dose of 40 mg/day. The authors also focused on the incidence of bleeding.

Source: Thromboprophylaxis 13. 6. 2022

News Brigatinib in Patients with ALK+ NSCLC –⁠ Final Results of the J-ALTA Clinical Study

At this year's American Society of Clinical Oncology (ASCO) conference held in Chicago in early June 2022, the final results of the J-ALTA clinical study were presented. So how did brigatinib perform in the treatment of patients with ALK-positive NSCLC who were refractory to alectinib?

Source: Non-Small Cell Lung Cancer 12. 9. 2022

News Impact of erdostein on bacterial biofilm −⁠ and what it means for clinical practice?

One of the substances that could potentially influence the success of treatments for infections associated with biofilm formation in the future is erdostein. This medication is used in the treatment of both acute and chronic diseases of the respiratory system (including chronic obstructive pulmonary disease) usually accompanied by increased mucus production. Its effect is mediated by several mechanisms that can also affect bacterial biofilm.

Source: Cough Therapy 28. 11. 2023

News The Importance of Adequate Protein Intake in Critical Patients –⁠ Analysis of Data from an International Study

Adequate protein intake is a necessary part of care for critically ill patients and mitigates catabolic reactions associated with severe illness or injury. The benefits of proper determination and adherence to protein intake, however, have not been sufficiently assessed in detail. Therefore, this topic was the focus of a work analyzing data from an international observational multicenter study published in the Journal of Parenteral and Enteral Nutrition.

Source: Parenteral Nutrition 16. 9. 2020

News Incidence of Brain Metastases and Intracranial Activity of Sotorasib in Patients with NSCLC with G12C Mutation of the KRAS Oncogene

Sotorasib is the first targeted drug approved for the treatment of metastatic non-small cell lung cancer (NSCLC) with the G12C mutation of the KRAS oncogene. The newly published study presented below investigated its intracranial activity.

Source: Lung Cancer 24. 5. 2023

News Cost-Effectiveness of Eletriptan in Acute Migraine Treatment

Even in a market dominated by generics, eletriptan 40 mg is among the most clinically effective and cost-efficient triptans for the acute treatment of migraine attacks. This was demonstrated by a systematic literature review focused on the pharmacoeconomic evaluation of this therapy, published by American authors in 2015. Its high cost-effectiveness may be due to its strong efficacy with a reduced need for additional treatment.

Source: Treatment of Severe Migraine 1. 6. 2022

Články časopisu Effect of resilience in women on the outcome of her first IVF/ICSI

Author of the article: Gabriela Ďurašková, Radek Hampl, J. Štěpán, M. Kupka Source: Česká gynekologie | 2/2014 21. 4. 2014

News Mental Health as an Overlooked Topic in Patients with Psoriasis

Psoriasis is an inflammatory, non-infectious disease primarily affecting the skin, and sometimes the nails, although in some patients, it manifests as psoriatic arthritis. To minimize the negative impact of these stigmatizing issues on patients' daily lives, not only optimal pharmacotherapy is crucial, but also the support of mental health.

Source: Psoriasis 4. 7. 2023

News Impact of Chronic Urticaria on Patients' Quality of Life and Society

An international team of dermatologists has mapped out the impact of chronic urticaria on various aspects of patients' lives and the economic burden this long-term disease, without available causal treatment, represents for society, according to available literature.

Source: Allergic Reactions 25. 8. 2021

News COVID-19 and MS: Do You Know the Risk Factors? What the American Registry Analysis Showed

An article published in the March issue of the prestigious journal JAMA Neurology summarizes the findings of an analysis of the course of COVID-19 in patients with multiple sclerosis in North America. Which patients are at greater risk of severe infection?

Source: Multiple Sclerosis 19. 4. 2021

News Incidence of Thromboembolic Disease During Military Operations –⁠ Results of a 10-Year Review

In contemporary armed conflicts, limb injuries account for more than half of all injuries. In addition to the characteristically high incidence of infectious complications, injuries associated with military medicine also carry a high risk of thromboembolic disease. This is demonstrated by a study assessing the incidence of thromboembolic disease in American soldiers over 10 years of military operations in the Middle East.

Source: Prevention of Thrombosis in Surgery 18. 5. 2020

News Reducing Overall Mortality by Combining Three Antihypertensives into a Single Pill

Treating hypertension to recommended target blood pressure values often requires a combination of three antihypertensives. By simply combining these three substances into a single pill, it is possible to increase treatment adherence, reduce overall mortality in hypertensive patients, and lower healthcare costs within one year. This is demonstrated by a freshly published Italian real-world study.

Source: Risk factors of cardiovascular diseases 26. 6. 2024

News How to Determine the Optimal Target Value of Intraocular Pressure in Glaucoma Treatment?

Glaucoma remains the second most common cause of blindness in Europe. Therapy needs to be individualized with regard to the severity of the condition, expected lifespan, and the rate of disease progression. Which factors should we consider when determining the optimal target value of intraocular pressure (IOP) for a particular patient?

Source: Treatment of Glaucoma 8. 9. 2023