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News Weight-Based Enoxaparin Dosing vs. Standard Dosing in Trauma Patients
Thromboembolic disease is a common comorbidity in adult trauma patients, thus making routine thromboprophylaxis appropriate for these patients, most often in the form of low-molecular-weight heparins (LMWH). Standard thromboprophylaxis dosing regimens, however, are often associated with insufficient anti-Xa activity levels. A recently published clinical study by researchers from New York University focused on comparing the standard thromboprophylaxis regimen of enoxaparin with a weight-based dosing regimen in adult trauma patients.
News Targeted Treatment and Quality of Life in Patients with Follicular Lymphoma
The GALLIUM clinical trial evaluated chemotherapy in combination with targeted treatment using rituximab or obinutuzumab in previously untreated patients with advanced follicular lymphoma (FL). A secondary aim of the study was to assess the health-related quality of life. The results of the analysis were recently published in the journal Annals of Hematology.
News Under the Microscope: How is Patient Care for Heart Failure in the Czech Republic in Real Practice?
The journal Vnitřní lékařství recently published the results of a survey conducted among outpatient cardiologists and internists. The aim was to determine the level of diagnosis and treatment of patients with chronic heart failure (CHF) in real-life practice in the Czech Republic, with a special focus on the presence of symptoms in patients who have not yet been diagnosed. We briefly summarize the key findings from this survey.
News Transthyretin Amyloidosis in Patients with Carpal Tunnel Syndrome
Carpal tunnel syndrome is considered a warning sign for cardiac amyloidosis. Amyloid deposits are often found in the tenosynovial material removed during surgery. However, the prevalence of concomitant cardiomyopathy is not yet fully understood. Japanese researchers from Kumamoto University recently focused on the relationship between carpal tunnel syndrome and cardiac amyloidosis in their newly published prospective study.
News Dupilumab Improves Skin and Systemic Symptoms of Atopic Dermatitis
A clinical study conducted in the USA and Canada demonstrated the efficacy of dupilumab in treating moderate to severe atopic dermatitis, improving both skin symptoms and suppressing systemic inflammatory markers.
News Non-factor vs. Factor Prophylaxis of Hemophilia A: A Comparison of Cost and Treatment Effectiveness Based on Real-World Data from the USA
In the prophylactic treatment of patients with hemophilia A, particularly its severe form, concentrates of clotting factor VIII (FVIII) with extended half-life (EHL) are increasingly administered, or non-factor treatment, represented in clinical practice by FVIII mimetic antibody emicizumab. However, insights into the direct comparison of effectiveness and economic burden arising from prophylaxis with these modalities are limited, including data from real-world practice. One recently published study therefore attempted to conduct such a retrospective comparison based on data from healthcare-related databases in the USA.
News Gliflozins Successfully Treat Type 2 Diabetes Mellitus and Heart Failure
The number of patients with type 2 diabetes mellitus (DM2) and heart failure is increasing worldwide, and the combination of both diseases significantly worsens the prognosis of patients. One of the main causes of increased mortality in these patients is macrovascular complications of DM2. The burden on the cardiovascular system is even greater with the concurrent occurrence of chronic heart failure.
News Stabilization of Liver Metastases of CRC with Trifluridine/Tipiracil in 3rd Line Therapy – Case Study
We present a case study of a man born in 1944 who underwent resection of the rectosigmoid for multiple adenocarcinomas in February 2016. Subsequently discovered liver metastases were managed with several lines of palliative therapy in combination with repeated surgical resections. Trifluridine/tipiracil administered in the 3rd line represents a well-tolerated oral treatment for this patient, on which he achieved disease stabilization.
News High pH of Wounds is Associated with Poorer Burn Healing
British scientists have shown that the pH of burn wounds decreases during healing and that higher pH at the second dressing change is associated with poorer healing and the subsequent need for skin grafts. Determining the pH of wounds at the beginning of treatment could help identify poorly healing burns that require more aggressive treatment.
News Balance and Rehabilitation – Firm on the Ground Even with Multiple Sclerosis
A large portion of patients with multiple sclerosis (MS) suffer from balance disorders. What are the options for non-pharmacological therapy for these issues according to the latest studies?
News Case Study with Voting: Intensification of Type 2 Diabetes Therapy in a Chronically Treated Patient. How to Proceed According to Current Recommendations?
We have prepared an interactive case study for you with a 70-year-old patient with decompensated Type 2 Diabetes. The patient was diagnosed with DM eight years ago. What treatment approach would you choose? And why? And how should you correctly proceed according to the current recommendations of SVL? Watch a short video with us.
News Current findings on the treatment of gestational diabetes and DM2 in pregnancy with metformin
Recent reviews have shown that metformin is a safe alternative to insulin in the treatment of diabetes during pregnancy. For gestational diabetes (GDM) and type 2 diabetes mellitus (DM2), metformin administered to pregnant women has its benefits, but also certain risks.
Journal articles Fertility preserving methods in women with breast cancer before gonadotoxic therapy
News Scientists Decipher the Perception of Bitter Taste. How Will This Help in the Development of New Drugs?
Taste receptors are a known phenomenon, but how exactly does taste perception occur? Scientists from the University of North Carolina focused on bitter taste, as it often accompanies medications. They hope their research will allow the application of their findings, for example, in the development of treatments for obesity or diabetes mellitus (DM).
News Measurement of Serum Trough Levels of IgG as an Adequate and Beneficial Indicator for Assessing the Pharmacokinetics of Subcutaneously Administered Products
For many patients with primary immunodeficiency, lifelong immunoglobulin substitution is essential to reduce the frequency of severe infections. Subcutaneous home administration is better accepted by patients. However, dosing needs to be customized to the patient. The study presented below may help make therapy individualization easier for doctors and more tolerable for patients.
News Subcutaneous vs. Intravenous Immunoglobulins in Patients with CLL
Secondary antibody immunodeficiency is a common complication in patients with chronic lymphocytic leukemia (CLL), and infections, along with secondary malignancies, are the leading cause of death in these patients. Hypogammaglobulinemia can be managed with immunoglobulin replacement therapy (IGRT). Besides the classic intravenous form (IVIG), a subcutaneous form (SCIG) is also available. An Italian retrospective study published in the journal Current Oncology compared their efficacy in secondary immunodeficiency in CLL patients.
News Mass in the Left Atrium Appendage - Case Report
A symptomatic mass in the left atrial appendage warrants thorough investigation and radical treatment – unless it is in the heart of a polymorbid patient, as was the case in the following report.
News Effect of Discontinuing Inhaled Corticosteroids in Patients with COPD in Real Clinical Practice
Inhaled corticosteroids are prescribed to patients with COPD to prevent disease exacerbation. However, in clinical practice, they are often overprescribed in non-indicated cases. A study conducted in real clinical conditions evaluated the effect of discontinuing inhaled corticosteroids compared to continuing triple therapy in patients with COPD.
News CASE STUDY: Key Benefits of GLP-1RA in Diabetes Therapy in the Office of a General Practitioner
Modern therapy using glucagon-like peptide-1 receptor agonists (GLP-1RA) offers diabetics highly effective management of their primary condition as well as several other advantages: it reduces the risk of hypoglycemia, aids in weight loss, and has a positive impact on the heart and blood vessels, including increasing the chances of preventing and delaying the progression of micro and macrovascular complications. Early initiation of this treatment not only significantly improves diabetes control but also helps in preventing or delaying the development of atherosclerosis and cardiometabolic syndrome.
News Idiopathic Pulmonary Fibrosis from the Perspective of an Outpatient Pulmonologist
Idiopathic pulmonary fibrosis represents a rare disease of lung tissue with an as-yet-unexplained etiology. In the framework of differential diagnosis, it is necessary to consider the disease, as early diagnosis combined with the deployment of antifibrotic therapy extends patients' lives.
News CASE STUDY: Oral Semaglutide in a Young Diabetic = Weight Loss and CV Risk Reduction, Better Adherence and Treatment Comfort
Diabetologist MUDr. Tomáš Pfohl from the Regional Hospital Liberec illustrates the benefits of therapy with oral semaglutide in a relatively young diabetic patient with type 2 DM after unsatisfactory disease compensation was not achieved with a combination of gliptin and metformin.
News A Brief History of Deep Vein Thrombosis Treatment – From Antiquity to the Present
Deep vein thrombosis is among the common diseases that have accompanied humanity since its inception. Due to the low specificity of its clinical presentation (in contrast to, for example, varicose veins of the lower limbs), however, the disease long went undescribed in literature. The first descriptions of deep vein thrombosis did not appear until the Middle Ages – and from that moment, the gradual development of its treatment began. We offer you a brief but remarkable historical excursion in three stages.
News Efficacy and Safety of Dual Bronchodilator Therapy for COPD – From Randomized Clinical Trials to Real-World Clinical Practice
Dual bronchodilator therapy (LAMA + LABA) represents one of the mainstays of treating chronic obstructive pulmonary disease (COPD). The aim of the recent systematic review presented below was to assess the efficacy and safety of this dual therapy compared to monotherapy or other combinations in the context of clinical trials and real-world clinical practice.