Recommendation of the Society for Transfusion Medicine No. 20 Cold red blood cell antibodies testing before cardiothoracic surgery on cardiopulmonary bypass

Czech version

Authors: M. Králová ¹; J. Masopust ²; M. Písačka ³; V. Řeháček ⁴; P. Turek ⁵
Authors‘ workplace: Ústav hematologie a krevní transfuze, Praha ¹; Transfuzní oddělení, Krajská zdravotní, a. s. – Masarykova nemocnice v Ústí nad Labem, o. z. ²; Ústav hematologie a krevní transfuze, Praha ³; Transfuzní oddělení, FN Hradec Králové ⁴; Transfúzní oddělení, Fakultní Thomayerova nemocnice, Praha ⁵
Published in: Transfuze Hematol. dnes,32, 2026, No. 1, p. 65-66.
Category: Best Practices
doi: https://doi.org/10.48095/cctahd202601

Overview

Cold red blood cell antibodies are usually clinically insignificant. However, they may have an adverse clinical impact in patients undergoing cardiac surgery with the use of cardiopulmonary bypass with cooling of the patient‘s blood. We present consensus recommendation for the screening and titration of cold red blood cell antibodies in these patients.

Keywords:

cardiac surgery – Cardiopulmonary bypass – cold RBC antibodies

Sources

1. Jalink M, Yan MTS, Cohn CS, et al. Systematic review for serological testing for cold agglutinins: The BEST collaborative study. Transfusion. 2024; 64 : 1331–1349.

2. Sapatnekar S, Figueroa PI. Cold antibodies in cardiovascular surgery. Is preoperative screening necessary? Am J Clin Pathol. 2016; 145 : 789–795.

3. Masopust J, Písačka M. AIHA s chladovými protilátkami. In: Praktická imunohematologie –⁠ erytrocyty (2. přepracované vydání). Grada Publishing 2022.

4. Nancy L, Van Buren MD. Cold Agglutinin Disease. In: Transfusion Medicine and Hemostasis (3rd ed.) 2019.

5. Foroughi M, Majidi M, Hekmat M, Beheshti M. What the cardiac surgeons have to know about cold agglutination management. Egypt J Cardiothor Anesth. 2014; 8 : 101–103.

6. Swiecicki PL, Hegerova LT, Gertz MA. Cold agglutinin disease. Blood. 2013; 122 (7): 1114–1121.

Do redakce doručeno dne: 7. 11. 2025.

Přijato do tisku dne: 11. 11. 2025.

MUDr. Jiří Masopust

Transfuzní oddělení KZ, a. s., Masarykova nemocnice v Ústí nad Labem, o.z.

Sociální péče 3316/12A

401 13 Ústí nad Labem

e-mail: jiri.masopust@kzcr.eu