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Recommendations for the diagnosis and treatment of chronic lymphocytic leukaemia (CLL) – 2018


Authors: M. Doubek 1;  M. Špaček 2;  Š. Pospíšilová 1;  M. Jarošová 1;  T. Papajík 3;  R. Urbanová 3;  M. Šimkovič 4;  D. Lysák 5;  M. Brejcha 6;  L. Smolej 4
Authors‘ workplace: Interní hematologická a onkologická klinika, Fakultní nemocnice a Lékařská fakulta Masarykovy Univerzity Brno 1;  I. interní klinika – klinika hematologie, 1. lékařská fakulta Univerzity Karlovy a Všeobecná fakultní nemocnice Praha 2;  Hemato-onkologická klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Palackého Olomouc 3;  IV. interní hematologická klinika, Fakultní nemocnice Hradec Králové a Lékařská fakulta Univerzity Karlovy v Hradci Králové 4;  Hematologicko-onkologické oddělení, Fakultní nemocnice Plzeň 5;  Hematologické oddělení, Onkologické centrum Nový Jičín 6
Published in: Transfuze Hematol. dnes,24, 2018, No. 3, p. 208-220.
Category:

Overview

Chronic lymphocytic leukaemia has a remarkably heterogeneous clinical course. The diagnostic procedures and therapeutic interventions need to be individually tailored according to patient age, comorbidities and therapeutic aims. There have been crucial developments in prognostication and therapy in recent years (e.g., significance of TP53 mutations, introduction of novel monoclonal antibodies, B-cell receptor signalling and Bcl-2 inhibitors). Therefore, the Czech CLL Study Group, the working group of the Czech Haematological Society, has developed these updated guidelines to facilitate the decision-making process for diagnosis and treatment in clinical practice. The guidelines are based on a comprehensive analysis of current literature and the principles of evidence-based medicine.

Key words:

chronic lymphocytic leukemia – diagnostics – treatment

Czech Group for Chronic Lymphocytic Leukaemia, section of the Czech Society of Haematology of the Czech medical Society of Jan Evangelista Purkyně


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