Authors: M. Doubek 1; K. Řeháková 2; P. Scheer 2; J. Doubek 2; J. Mayer 1 Authors‘ workplace: Interní hematoonkologická klinika Lékařské fakulty Masarykovy univerzity a FN Brno, 2Ústav fyziologie a patofyziologie Fakulty veterinárního lékařství Veterinární a farmaceutické univerzity, Brno 1 Published in: Transfuze Hematol. dnes,, 2004, No. 4, p. 149-153. Category:
Experimental models of human leukaemias are used in attempts to reconstruct events that occur inpatients with this cancer. Although in vitro systems provide a wealth of information about the cellularand molecular biology of leukaemic cells, they are inadequate for studies that address the complexitiesof human leukaemia and experimental treatment of this disease. Since the late 1960s, athymic nudemice have provided an opportunity to study xenografted human leukaemia in vivo. Recently, thesuccessful engraftment of human haematopoietic cells into various immune-deficient mice offers anapproach to study human haematopoiesis and leukaemia. The goals of this review are to discuss howmouse models have been utilized to study human leukaemia, and to provide an assessment of thestrengths and limitations of mouse models.
Key words: immune-deficient mouse, leukaemia, SCID mouse, xenograft
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