Authors: V. Kuhrová; H. Francová; D. Klimešová; J. Mayer Authors‘ workplace: Centrum molekulární biologie a genové terapie, Interní hematoonkologická klinika, Fakultní nemocnice, Brno Published in: Transfuze Hematol. dnes,, 2004, No. 4, p. 143-148. Category:
B-cell chronic lymphocytic leukemia (B-CLL) is the most frequent adult type of leukemia in theWesterncountries. It is characterized by the therapeutically uncontrolled accumulation of functionally incompetentlymphocytes in bone marrow, blood and lymph nodes. The development of the disease isheterogenous with distinctive clinical features and individual evaluation of aggresivity is highlyrecommended for optimal treatment. For this purpose FISH method of identification of genomicaberrations could be used. At present, the new prognostic criterion is accepted – determination of themutational status of variable region VH of the immunoglobulin heavy chain. This aspect, comparingtumor B-cell nucleotide sequence homology with a germline, separates CLL into two different subsetswith markedly different prognoses. A group with an unmutated VH genes with sequence homology >98% displays progressive disease in contrast to the second group with mutated VH genes and homology
Key words: chronic lymphocytic leukemia, immunoglobulin heavy chain gene, VDJ subgene rearrangement,VH mutational status, prognostic criterium of the aggresivity CLL
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