Authors: P. U. Durgakeri; M. Kaška Authors‘ workplace: Katedra chirurgie Lékařské fakulty UK Praha v Hradci Králové, vedoucí prof. MUDr. Z. Vobořil, DrSc. Published in: Rozhl. Chir., 2006, roč. 85, č. 6, s. 286-289. Category: Monothematic special - Original
This article deals with the current knowledge on the possibilities of intraperitoneal adhesion prophylaxis in correlation with intraperitoneal interventions in abdominal surgery. The up-to-date experimental possibilities and other known methods are presented. These include: Intraperitoneal perfusion by certain special simple solutions - Dextran, Carboxymethycellulose, Crystalloid solutions, and Hyaluronidase. Intraperitoneal or other administration of certain drugs - Tetracyclines, Cephalosporins, Corticosteroids, Non-Steroidal Anti-inflammatory drugs, Histamine agonists, Ca-channel blockers, Heparin, Citrates and Oxalates, Streptokinase, Urokinase, Plasminogen activators, and application of special synthetic or natural materials intraperitoneally – Surgicel, Interceed, Gore-Tex, Fibrin Glue, or various combinations of the above mentioned. Rats, rabbits, and mousses were used, first of all, as an animal model in presented experiments.
Key words: postoperative adhesions – experimental antiadhesive materials and substances
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