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Extranodal NK/T Cell Lymphoma, Nasal Type - an Unusual Cause of Unilateral Nasal Obstruction


Authors: D. Kalfeřt 1;  Petra Kašparová 2;  P. Čelakovský 1
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku, Fakultní nemocnice Hradec Králové, Lékařská fakulta v Hradci Králové Univerzity Karlovy v Praze, přednosta prof. MUDr. V. Chrobok, CSc., Ph. D. 1;  Fingerlandův ústav patologie, Fakultní nemocnice Hradec Králové, Lékařská fakulta v Hradci Králové Univerzity Karlovy v Praze, přednosta prof. MUDr. A. Ryška, Ph. D. 2
Published in: Otorinolaryngol Foniatr, 61, 2012, No. 2, pp. 130-134.
Category: Case Reports

Overview

Extranodal NK/T-cell lymphoma, nasal type is very rare disease with aggressive behavior. It occurs more frequently in Asian countries, typically affects adults men. Disease is associated with Epstein-Barr virus infection. The incidence is usually unilateral with infiltration of the nasal turbinate and spread to surrounding tissues. In the early stages of the disease is manifested non-specific rhinitis or sinusitis and nasal obstruction. Among the late symptoms include epistaxis, facial swelling, ulceration soft tissue, or even painful middle facial destruction.

In our case, we present the clinical course of NK/T-cell lymphoma, nasal type in 24-year-old woman who was examined primarily due to unilateral nasal obstruction. The clinical findings, diagnosis and therapy of this rare disease are discussed.

Key words:
nasal obstruction, nasal NK/T-cell lymphoma, sinonasal lymphoma.


Sources

1. Aozasa, K., Takakuwa, T., Hongyo, T., Yang, W.I.: Nasal NK/T-cell lymphoma: epidemiology and pathogenesis. Intm. J. Hematol., 87, 2008, 2, s. 110-117.

2. Aozasa, K., Zaki, M.: Epidemiology and pathogenesis of Nasal NK/T-Cell Lymphoma: A mini-review. Scientific World Journal, 11, 2011, s. 422-428.

3. Belada, D., Trněný, M. a kolektiv autorů Kooperativní lymfomové skupiny: Diagnostické a léčebné postupy nemocných maligními lymfomy IV. šesté (4. tištěné), doplněné a přepracované vydání, 2011, s. 138.

4. Das, S., Kirsch, C. F.: Imaging of lumps and bumps in the nose: a review of sinonasal tumours. Cancer Imaging, 5, 2005, s. 167-177.

5. Fraser, L., Kelly, G.: An evidence-based approach to the management of the adult with nasal obstruction. Clin. Otolaryngol., 34, 2009, 2, s. 151-155.

6. Ketharanathan, N., van Kipshagen, P. J., Vasmel, W., Barbe, E., de Vries, N.: T/NK cell lymphoma presenting as a „blocked nose“. European archives of oto-rhino-laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Societies, 265, 2008, 9, s. 1131-1134.

7. Metgud, R. S., Doshi, J. J., Gaurkhede, S., Dongre, R., Karle, R.: Extranodal NK/T-cell lymphoma, nasal type (angiocentric T-cell lymphoma): A review about the terminology. J. Oral Maxillofac. Pathol., 15, 2011, 1, s. 96-100.

8. Moumine, M., Sabani, H., Qamous, W., Nassih, M., Al Bouzidi, A., Rzin, A.: Maxillary T/NK lymphoma. Case report. Revue de Stomatologie et de Chirurgie Maxillo-faciale, 112, 2011, 2, s. 113-116.

9. Ou, C. H., Chen, C. C., Ling, J. C., Chai, J. W., Wu, C. H., Chen, W.H., Hung, H. C., Tain, L., Ho, T. L.: Nasal NK/T-cell lymphoma: computed tomography and magnetic resonance imaging findings. J. Chin. Med. Assoc., 70, 2007, 5, s. 207-212.

10. Reyes, V. E., Jr., Al-Saleem, T., Robu, V. G., Smith, M. R.: Extranodal NK/T-cell lymphoma nasal type: efficacy of pegaspargase. Report of two patients from the United Sates and review of literature. Leukemia Research, 34, 2010, 1, s. e50-54.

11. Rezk, S. A., Huang, Q.: Extranodal NK/T-cell lymphoma, nasal type extensively involving the bone marrow. Int. J. Clin. Exp. Pathol., 4, 2011, 7, s. 713-717.

12. Sands, N. B., Tewfik, M. A., Hwang, S. Y., Desrosiers, M.: Extranodal T-cell lymphoma of the sinonasal tract presenting as severe rhinitis: case series. Journal of otolaryngology - head & neck surgery = Le Journal d‘oto-rhino-laryngologie et de chirurgie cervico-faciale, 37, 2008, 4, s. 528-533.

13. Stadlmann, S., Fend, F., Moser, P., Obrist, P., Greil, R., Dirnhofer, S.: Epstein-Barr virus-associated extranodal NK/T-cell lymphoma, nasal type of the hypopharynx, in a renal allograft recipient: case report and review of literature. Hum. Pathol., 32, 2001, 11, s. 1264-1268.

14. Tomsová, M.: Jaká je vaše diagnóza? Odpověd‘: Extranodální lymfom z NK/T buněk, nazální typ. Česko-slovenská patologie a Soudní lékařství, 43, 2007, 2, s. 58, 73-74.

15. Van Prooyen Keyzer, S., Eloy, P., Delos, M., Doyen, C., Bertrand, B., Rombaux, P.: Sinonasal lymphomas. Case report. Acta Oto-Rhino-Laryngologica Belgica, 54, 2000, 1, s. 45-51.

16. Vega, F., Lin, P., Medeiros, L. J.: Extranodal lymphomas of the head and neck. Annals of Diagnostic Pathology, 9, 2005, 6, s. 340-350.

17. Wood, P. B., Parikh, S. R., Krause, J. R.: Extranodal NK/T-cell lymphoma, nasal type. Proc (Bayl Univ Med Cent), 24, 2011, 3, s. 251-254.

18. Yen, T. T., Wang, R. C., Jiang, R.  S., Chen, S. C., Wu, S. H., Liang, K. L.: The diagnosis of sinonasal lymphoma: a challenge for rhinologists. European archives of oto-rhino-laryngology: Official Journal of the European Federation of Oto-Rhino-Laryngological Societies, 2011, e-pub.

19. Zhang, X. X., Xie, C. H., Xu, Y., Deng, D., Zhao, Y. H., Zou, B. W., Zhou, L., Li, M., Wang, J., Liu, W. P. et al: Salvage treatment improved survival of patients with relapsed extranodal natural killer/t-cell lymphoma, nasal type. Int. J. Radiat. Oncol Biol. Phys., 74, 2009, 3, s. 747-752.

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Audiology Paediatric ENT ENT (Otorhinolaryngology)
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