The Relationship between Human Papillomavirus Infection and the Etiology of Tonsillar Cancer
Authors:
E. Rotnáglová 1,2; R. Tachezy 2; M. Saláková 2; E. Košľabová 1,2; J. Šmahelová 2; E. Hamšíková 2; V. Ludvíková 2; J. Klozar 1
Authors‘ workplace:
Klinika otorinolaryngologie a chirurgie hlavy a krku 1. LF UK a FN Motol, Praha, Katedra IPVZ, Praha
1; Oddělení experimentální virologie, Ústav hematologie a krevní transfuze, Praha
2
Published in:
Otorinolaryngol Foniatr, 59, 2010, No. 1, pp. 32-37.
Category:
Comprehensive Reports
Overview
Head and neck cancers present an important part of all malignancies worldwide and the incidence of some of its subtypes is rising constantly. Most important risk factors are smoking and alcohol consumption, but in the last decade evidence has been accumulated that a part of head and neck cancers is caused by the infection of human papillomaviruses. HPV had already been established as an etiological factor of cervical cancer in women. HPV infection is most frequently detected in tonsillar cancers. This work gives an overview of current knowledge about the role of HPV in the etiology of tonsillar cancers, describes methods for diagnosis of HPV infection in head and neck cancer patients. Due to the fact that several studies had shown that patients with HPV associated tumors have better prognosis, diagnosis of HPV involvement in these tumors might be an important criterion for selection of patients to the treatment regime. This article also includes results of studies which were done on the population of patients and controls from the Czech Republic.
Key words:
head and neck cancers, papillomaviruses, tonsillar cancers.
Sources
1. 2009. Novotvary 2006 ČR/ Cancer Incidence 2006 CR: Ústav zdravotnických informací a statistiky ČR ve spolupráci s Národním onkologickým registrem ČR.
2. Agrawal, Y., Koch, W. M., Xiao, W. et al.: Oral human papillomavirus infection before and after treatment for human papillomavirus 16-positive and human papillomavirus 16-negative head and neck squamous cell carcinoma. Clin. Cancer Res., 14, 2008, s. 7143-7150.
3. Andl, T., Kahn, T., Pfuhl, A. et al.: Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res., 58, 1998, s. 5-13.
4. Applebaum, K. M., Firnise, C. S., Zeka, A. et al.: Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer. J. Natl. Cancer Indy., 99, 2007, s. 1801-1810.
5. Braakhuis, B. J., Snijders, P. J., Kecne, W. J. et al.: Genetic patterns in head and neck cancers that contain or lack transcriptionally active human papillomavirus. J. Natl. Cancer Indy., 96, 2004, s. 998-1006.
6. Castellsague, X., Quintana, M. J, Martinez, M. C. et al.: The role of type of tobacco and type of alcoholic beverage in oral carcinogenesis. Int. J. Cancer, 108, 2004, s. 741-749.
7. D’Souza, G., Kreimer, A. R., Viscidi, R. et al.: Case-control study of human papillomavirus and oropharyngeal cancer. N. Engl. J. Med., 356, 2007, s. 1944-1956.
8. Dahlstrand, H., Nasman, A., Romanitan, M. et al.: Human papillomavirus accounts both for increased incidence and better prognosis in tonsillar cancer. Anticancer Res., 28, 2008, 1133-1138.
9. Dahlstrand, H. M., Dalianis, T.: Presence and influence of human papillomaviruses (HPV) in Tonsillar cancer. Adv. Cancer Res., 93, 2005, s. 59-89.
10. de Villiers, E. M., Fauquet, C., Broker, T. R. et al.: Classification of papillomaviruses. Virology, 324, 2004, s. 17-27.
11. Frish, M., Biggar, R. J.: Aetiological parallel between tonsillar and anogenital squamous-cell carcinomas. Lancet, 354, 2009, s. 1442-1443.
12. Frish, M., Hjalgrim, H., Jaeger, A. B., Biggar, R. J.: Changing patterns of tonsillar squamous cell carcinoma in the United States. Cancer Causes Kontrol, 11, 2000, s. 489-495.
13. Gasco, M., Crook, T.: The p53 network in head and neck cancer. Oral Oncol., 39, 2003, s. 222-231.
14. Gillison, M. L., Koch, W. M., Capone, R. B. et al.: Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J. Natl. Cancer Indy., 92, 2000, s. 709-720.
15. Gillison, M. L , Koch, W. M., Shah, K. V.: Human papillomavirus in head and neck squamous cell carcinoma: are some head and neck cancers a sexually transmitted disease? Curr Opin Oncol., 11, 1999, s. 191-199.
16. Hafkamp, H., Ernst, J. M. S., Annick, H. et al.: A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int. J. Cancer, 107, 2003, 3, s. 394-400.
17. Hafkamp, H. C., Manni, J. J., Haesevoets, A. et al.: Marked differences in survival rate between smokers and nonsmokers with HPV 16-associated tonsillar carcinomas. Int. J. Cancer, 122, 2008, s. 2656-2664.
18. Hafkamp, H. C., Mooren, J. J., Claessen, S. M. et al.: P21(Cip1/WAF1) expression is strongly associated with HPV-positive tonsillar carcinoma and a favorable prognosis. Mod Pathol., 22, 2009, 5, s. 686-698.
19. Hammarstedt, L., Dahlstrand, H., Lindquist, D. et al.: The incidence of tonsillar cancer in Sweden is increasing. Acta Otolaryngol., 127, 2007, s. 988-992.
20. Hammarstedt, L., Lindquist, D., Dahlstrand, H. et al.: Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer, 119, 2006, s. 2620-2623.
21. Hashibe, M., Brennan, P., Benhamou, S. et al.: Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers, and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. J. Natl. Cancer Indy., 99, 2007, s. 777-789.
22. Hashibe, M., Brennan, P., Chuang, S. C. et al.: Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol. Biomarkers Prev., 18, 2009, s. 541-550.
23. Hemminki, K., Dong, C., Triech, M.: Tonsillar and other upper aerodigestive tract cancers among cervical cancer patients and their husbands. Eur. J. Cancer Prev., 9, 2000, s. 433.
24. Herrero, R., Castellsague, X., Pawlita, M. et al.: Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J. Natl. Cancer Indy., 95, 2003, s. 1772-1783.
25. Hobbs, C. G., Sterne, J. A., Bailey, M. et al.: Human papillomavirus and head and neck cancer: a systematic review and meta-analysis. Clin. Otolaryngol., 31, 2006, s. 259-266.
26. Chen, R., Sehr, P., Waterboer, T. et al.: Presence of DNA of human papillomavirus 16 but no other types in tumor-free tonsillar tissue. J. Clin. Microbiol., 43, 2005, s. 1408-1410.
27. Kim, S. H., Koo, B. S., Kang, S. et al.: HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int. J. Cancer, 120, 2007, s. 1418-1425.
28. Klozar, J., Kratochvil, V., Salákova, M. et al.: HPV status and regional metastasis in the prognosis of oral and oropharyngeal cancer. Eur. Arch. Otorhinolaryngol., 265, 2008, (suppl. 1), s. S75-S82.
29. Klozar, J., Zábrodský, M., Kodet R., Saláková M., Šmahelová J., Ludvíková V., Hamšíková E., Tachezy R.: Humánní papillomaviry v etiologii karcinomu ústní dutiny a orofaryngu. Otorinolaryngologie a Foniatrie, 56, 2007, s. 73-81.
30. Klussmann, J. P., Weissenborn, S. J., Wieland, U. et al.: Human papillomavirus-positive tonsillar carcinomas: a different tumor entity? Med. Microbiol. Immunol., 192, 2003, s. 129-132.
31. Klussmann, J. P., Weissenborn, S. J., Wieland, U. et al.: Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer, 92, 2001, s. 2875-2884.
32. Koskinen, W. J., Chen, R. W., Leivo, I. et al.: Prevalence and physical status of human papillomavirus in squamous cell carcinomas of the head and neck. Int. J. Cancer, 107, 2003, s. 401-406.
33. Kreimer, A. R., Clifford, G. M., Boyle, P., Franceschi, S.: Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol. Biomarkers Prev., 14, 2005, s. 467-475.
34. Kumar, B., Cordell, K. G., Lee, J. S. et al.: Response to therapy and outcomes in oropharyngeal cancer are associated with biomarkers including human papillomavirus, epidermal growth factor receptor, gender, and smoking. Int. J. Radiat. Oncol. Biol. Phys., 69, 2007, s. 109-111.
35. Kumar, B., Cordell, K. G., Lee, J. S. et al.: EGFR, p16, HPV Titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J. Clin. Oncol., 26, 2008, s. 3128-3137.
36. Kuo, K. T., Hsiao, C. H., Lin, C. H. et al.: The biomarkers of human papillomavirus infection in tonsillar squamous cell carcinoma-molecular basis and predicting favorable outcome. Mod. Pathol., 21, 2008, s. 376-386.
37. Li, W., Thompson, C. H., O’Brien, C. J. et al.: Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. Int. J. Cancor, 106, 2003, s. 553-558.
38. Lindel, K., Beer, K. T., Laissue, J. et al.: Human papillomavirus positive squamous cell carcinoma of the oropharynx: a radiosensitive subgroup of head and neck carcinoma. Cancer, 92, 2001, s. 805-813.
39. Llewellyn, C. D., Linklater, K., Bell, J. et al.: Squamous cell carcinoma of the oral cavity in patients aged 45 years and under: a descriptive analysis of 116 cases diagnosed in the South East of England from 1990 to 1997. Oral Oncol., 39, 2003, s. 106-114.
40. Mellin, H., Dahlgren, L., Munck-Wikland, E. et al.: Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int. J. Cancer, 102, 2002, s. 152-158.
41. Mellin, H., Friesland, S., Lewensohn, R. et al.: Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int. J. Cancer, 89, 2000, s. 300-304.
42. Mellin, H. D., Munck-Wikland, E., Dahlgren, L., Dalianis, T.: Occurrence of human papillomavirus is a positive factor in tonsillar cancer. Reduced risk of recurrence and longer survival]. Lakartidningen, 101, 2004, s. 2794-2796, 2798.
43. Munoz, N., Castellsague, X., de Gonzalez, A. B., Gissmann, L.: Chapter 1: HPV in the etiology of human cancer. Vaccine, 24, 2006, (suppl. 3), s. S1-S10.
44. Nasman, A., Attner, P., Hammarstedt, L. et al.: Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: An epidemic of viral-induced carcinoma? Int. J. Cancer, 2009.
45. Parkin, D. M., Bray, F., Ferlay, J., Pisani, P.: Global cancer statistics, 2002. CA Cancer J. Clin., 55, 2005, s. 74-108.
46. Psyrri, A., DiMaio, D.: Human papillomavirus in cervical and head-and-neck cancer. Nat. Clin. Pract. Oncol., 5, 2008, s. 24-31.
47. Purdue, M. P., Hashibe, M., Berthiller, J. et al.: Type of alcoholic beverage and risk of head and neck cancer—a pooled analysis within the INHANCE Consortium. Am. J. Epidemiol., 169, 2009, s. 132-142.
48. Ragin, C. C., Modugno, F., Gollin, S. M.: The epidemiology and risk factors of head and neck cancer: a focus on human papillomavirus. J. Dent. Res., 86, 2007, s. 104-114.
49. Ritchie, J. M., Smith, E. M., Summersgill, K. F. et al.: Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int. J. Cancer, 104, 2003, s. 336-344.
50. Schantz, S. P., Yu, G. P.: Head and neck cancer incidence trends in young Americans, 1973-1997, with a special analysis for tongue cancer. Arch. Otolaryngol. Head Neck Surg., 128, 2002, s. 268-274.
51. Schwarz, S. M., Daling, J. R., Doody, D. R. et al.: Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. J. Natl. Cancer Inst., 90 1998, s. 1626-1636.
52. Smeets, S. J., Braakhuis, B. J., Abbas, S. et al.: Genome-wide DNA copy number alterations in head and neck squamous cell carcinomas with or without oncogene-expressing human papillomavirus. Oncogene, 25, 2006, s. 2558-2564.
53. Smeets, S. J., Hesselink, A. T., Speel, E. J. et al.: A novel algorithm for reliable detection of human papillomavirus in paraffin embedded head and neck cancer specimen. Int. J. Cancer, 121, 2007, s. 2465-2472.
54. Smith, E. M., Ritchie, J. M., Summersgill, K. F. et al.: Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int. J. Cancer, 108, 2004, s. 766-772.
55. Smith, E. M., Wang, D., Kim, Y. et al.: P16INK4a expression, human papillomavirus, and survival in head and neck cancer. Oral Oncol., 44, 2008, s. 133-142.
56. Straetmans, J. M., Olthof, N., Mooren, J. J. et al.: Human papillomavirus reduces the prognostic value of nodal involvement in tonsillar squamous cell carcinomas. Laryngoskope, 2009.
57. Strome, S. E., Savva, A., Brissett, A. E. et al.: Squamous cell carcinoma of the tonsils: a molecular analysis of HPV associations. Clin. Cancer Res., 8, 2002, s. 1093-1100.
58. Sturgis, E. M., Cinciripini, P. M.: Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer, 110, 2007, s. 1429-1435.
59. Sturgis, E. M., Wei, Q., Spitz, R.: Descriptive epidemiology and risk factors for head and neck cancer. Semin Oncol., 31, 2004, s. 726-733.
60. Syrjanen, S.: HPV infections and tonsillar carcinoma. J. Clin. Pathol., 57, 2004, s.449-455.
61. Tachezy, R., Klozar, J., Rubenstein, L. et al.: Demographic and risk factors in patients with head and neck tumors. J. Med. Virol., 81, 2009, s. 878-887.
62. Tachezy, R., Klozar, J., Salákova, M. et al.: HPV and other risk factors of oral cavity/oropharyngeal cancer in the Czech Republic. Oral Dis., 11, 2005, s. 181-185.
63. Tsoumpou, I., Arbyn, M., Kyrgiou, M. et al.: p16(INK4a) immunostaining in cytological and histological specimens from the uterine cervix: a systematic review and meta-analysis. Cancer Treat. Rev., 35, 2009, s. 210-220.
64. Weinberger, P. M., Yu, Z., Haffty, B. G. et al.: Molecular classification identifies a subset of human papillomavirus—associated oropharyngeal cancers with favorable prognosis. J. Clin. Oncol., 24, 2006, s. 736-747.
65. Weinberger, P. M., Yu, Z., Haffty, B. G. et al.: Prognostic significance of p16 protein levels in oropharyngeal squamous cell cancer. Clin. Cancer Res., 10, 2004, s. 5684-5691.
66. Westra, W. H., Taube, J. M., Poeta, M. L. et al.: Inverse relationship between human papillomavirus-16 infection and disruptive p53 gene mutations in squamous cell carcinoma of the head and neck. Clin. Cancer Res., 14, 2008, s. 366-369.
67. Wise Draper, T. M., Susanne, I. W.: Papillomavirus E6 and E7 proteins and their cellular targets. Frontiers in Bioscience, 2008, s. 1003-1017.
68. Wiseman, S. M., Swede, H., Stoler, D. L. et al.: Squamous cell carcinoma of the head and neck in nonsmokers and nondrinkers: an analysis of clinicopathologic characteristics and treatment outcomes. Ann. Surg. Oncol., 10, 2003, s. 551-557.
69. Zhao, M., Rosenbaum, E., Carvalho, A. L. et al.: Feasibility of quantitative PCR-based saliva rinse screening of HPV for head and neck cancer. Int. J. Cancer, 117, 2005, s. 605-610.
70. zur Hausen, H.: Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J. Natl. Cancer Inst., 92, 2000, s. 690-698.
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