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AtomLab 500 Radionuclide Calibrator: Advantages and Disadvantages of Built-in Attenuator Tube Linearity Test vs. Source Decay Method


Authors: J. Štěpán
Authors‘ workplace: Oddělení nukleární medicíny, Uherskohradišťská nemocnice a. s., Uherské Hradiště, ČR ;  Klinika radiologie a nukleární medicíny, FN Brno a LF MU Brno – Bohunice
Published in: NuklMed 2023;12:46-53
Category: Original Article

Overview

Introduction: In the draft recommendation of the State Office for Nuclear Safety (SÚJB) the following quality assurance tests are prescribed for radionuclide calibrators: background, short-term stability, long-term stability, linearity, geometric efficiency (volume dependence). For the system linearity test, only the method based on source decay is recommended, however AtomLab 500 includes built-in linearity tests for both this method and the method with attenuation tubes (lineator). The purpose of the article is to compare both built-in methods and point out mutual advantages and disadvantages.

Method: Automated linearity test based on source decay and linearity test with attenuation tubes (lineator) according to the manufacturer's instructions AtomLab 500 (Biodex). Initial 99mTc activities for the first method were 13.08 GBq and additional 37.4 MBq, measurement intervals of 6 h and test completion below 0.37 MBq, for the second method, 99mTc activities for 2 different combinations of lineator tubes were 11.53 GBq and 1811 MBq and test execution within 6 minutes. The measured data were evaluated using radionuclide calibrator software (graphs, tables, deviations from linearity – ±5 % are allowed).

Results: Tables and semilogarithmic graphs of measured linearity test values based on source decay for two default activities (second low one was additional, see below) and tables of linearity test values with lineator for two activities and calculated deviations from system linearity. The test with the second low activity (37.4 MBq 99mTc) in the first method was supplemented due to the unsatisfactory last value of the test with high activity (13.08 GBq 99mTc) – the device passed overall.

Conclusion: The linearity test performed with the AtomLab 500 according to the manufacturer's instructions once every 3 months is shortened from the original 3–4 d for the method based on the decay of the source to approximately 25 min (including sample preparation) for the lineator method and the device is not blocked unnecessarily. The disadvantage is the necessity of calibrating the lineator before its 1st use, after replacement, damage, after intervention in the device and proving the linearity of the system by the default method based on the decay of the source before starting to use the lineator method.

 

Keywords:

technetium-99m – attenuation (shielding) tube – attenuator – background – short-term stability – long-term stability – linearity – geometric efficiency – volume dependence – molybdenum-99


Sources
  1. ČSN EN 61303. Zdravotnické elektrické přístroje - Měřiče aktivity - Zvláštní metody pro stanovení parametrů. Praha, Český normalizační institut, 1997, 20 s
  2. ČMI. Opatření obecné povahy, kterým se stanovují metrologické a technické požadavky na stanovená měřidla, včetně metod zkoušení pro schvalování typu a ověřování stanovených měřidel: „měřidla aktivity diagnostických a terapeutických preparátů aplikovaných in vivo pacientům". [online] Číslo 0111-OOP-C017-10. Brno, Český metrologický institut, 12. 7. 2011 [cit. 2023-08-03]. Dostupné na: <https://www.cmi.cz/sites/all/files/public/download/Uredni_deska/3417-ID-C_3417-ID-C_0.pdf>
  3. SÚJB. Radiační ochrana v nukleární medicíně - systém kontrol detekční a zobrazovací techniky [online]. Revize č. 1.0. Praha, Státní úřad pro jadernou bezpečnost, únor 2019 [cit. 2023-08-03]. Pracovní verze dokumentu. Dostupné na: <https://www.sujb.cz/fileadmin/sujb/docs/radiacni-ochrana/lekarske_ozareni/Doporuceni_NM/pracovni_verze_pristrojova_technika.pdf>
  4. Code of Federal Regulations, Title 10, Chapter 1, Part 35, Subpart C, § 35.60 [online]. Washington, DC, U.S. Nuclear Regulatory Commission, 1995 [cit. 2023-08-03]. Dostupné na: <https://www.ecfr.gov/current/title-10/chapter-I/part-35/subpart-C/section-35.60>
  5. Biodex. Quality Assurance Testing of AtomLab® Dose Calibrators : Manufacturer’s Instructions. P/N 107012 Rev. G. Melbourne, FL, Sun Nuclear Corporation, 15 February 2010, 8 p
  6. SÚJB. Systém zabezpečení jakosti na pracovištích nukleární medicíny - přístrojová technika [online]. Praha, Ústav jaderných informací Zbraslav, květen 1999 [cit. 2023-08-03]. Dostupné na: <https://www.sujb.cz/fileadmin/sujb/docs/dokumenty/publikace/15_pristrojova_technika.pdf>
  7. Biodex. LINEATOR : INSTALLATION/OPERATION MANUAL. FN: 07-072 Rev B 08/11. New York, Biodex, 2011, 12 p
  8. Biodex. ATOMLAB 500 DOSE CALIBRATOR : OPERATION AND SERVICE MANUAL. FN: 10-096 Rev G 3/16. New York, Biodex, 2016, 247 p
  9. National Nuclear Data Center. Nuclear Decay Data in the MIRD Format [online]. Upton, NY, National Nuclear Data Center [cit. 2023-08-03]. Dostupné na: <https://www.nndc.bnl.gov/nudat3/mird/>
  10. Chu RYL, Simon WE. Quality Control Testing of Dose Calibrators. J Nucl Med Technol 1996;24:124-128
  11. Ministerstvo zdravotnictví ČR. Český lékopis 2017 – Doplněk 2022 [online E-kniha]. Praha, Grada, 2022 [cit. 2023-08-03]. Zahrnuje všechny platné lékopisné texty ČL 2017, ČL 2017 – Doplněk 2018, ČL 2017 – Doplněk 2019, ČL 2017 – Doplněk 2020, ČL 2017 – Doplněk 2021 a ČL 2017 – Doplněk 2022. Dostupné na: < https://www.grada.cz/cesky-lekopis-2017-doplnek-2022-12927/>
Labels
Nuclear medicine Radiodiagnostics Radiotherapy
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