Polydentate ligands for modern radiopharmaceuticals containing 64Cu – review

Authors: Roman Staník;  Jan Světlík
Authors‘ workplace: Katedra farmaceutickej analýzy a nukleárnej farmácie, FaF UK v Bratislave, Slovensko
Published in: NuklMed 2013;2:2-6
Category: Review Article


Molecular imaging techniques (PET, SPECT) play a major role in nuclear medicine. 64Cu appears to be the important radionuclide having the potential to find the application in the diagnostic as well as in the therapy. However, 64Cu must be delivered to the living system in the form of radiopharmaceutical with targeted biodistribution and sufficient in vivo stability. Therefore, polydentate ligand forming the complex compound with the copper radionuclide is often the essential part of the whole radiopharmaceutical. This review is devoted to the classification of ligands which can produce chelate with 64Cu.

Key words:
polydentate ligands, 64Cu, modern radiopharmaceuticals, review


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