New paradigm of therapeutic antibiotic monitoring
Authors:
Jana Gregorová
Authors‘ workplace:
Oddělení klinické farmacie, Fakultní nemocnice Bulovka, Praha
Published in:
Čas. Lék. čes. 2026; 165: 141-145
Category:
Review Article
Overview
Therapeutic antibiotic monitoring allows for the assessment of whether the chosen dosage leads to the achievement of the desired pharmacokinetic-pharmacodynamic (PK/PD) indices in a specific patient. The modern concept of therapeutic drug monitoring (TDM) goes beyond merely comparing to the therapeutic range and emphasizes the determination of an individual therapeutic target. Knowledge of PK/PD indices: Cmax/MIC, AUC/MIC, and fT>MIC is crucial for optimizing treatment and minimizing the risk of toxicity. TDM is a tool of personalized pharmacotherapy. TDM represents a process and includes individual steps, the implementation of which into routine practice contributes to the rationalization and safety of antibiotic therapy.
Keywords:
Therapeutic drug monitoring – pharmacokinetics – antibiotics – pharmacodynamics – PK/PD indices – individualized dosing
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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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