Contemporary possibilities of non-oral estrogen-progestin contraception
Authors:
Daniel Driák
Authors‘ workplace:
Gynekologicko-porodnická klinika 1. LF UK a Nemocnice Na Bulovce, Praha
Published in:
Čas. Lék. čes. 2014; 153: 142-145
Category:
Original Article
Overview
Besides the classic combined oral contraception (pill), there are alternative medical forms as transdermal contraception system, vaginal ring, intramuscular injections, and percutaneous gel, respectively. The mechanism of contraceptive effect is the same as well as they are the contraindications. The advantage of non-oral application is the elimination of the first-pass effect that enables reduction of doses, diminishing of undesirable side-effects and medical interactions, and only small effect on enzymatic systems associated with cytochrome P450. As the main advantage, comfort and better compliance of patients who have problems with daily use of tablets, is considered.
Keywords:
non-oral application – transdermal system – vaginal ring – intramuscular injection – percutaneous gel
Sources
1. Henshaw SK. Unintended pregnancy in the United States. Fam Plann Perspect 1998; 30(1): 24– 29.
2. Transdermální kontraceptivum: význam pro praxi. Komentář: Cibula D. Gynek. po prom. 2003; 3(4): 17–26.
3. Doležal P. Transdermální aplikace léčiv. Lék. Listy 2004; 53(41): 16–17.
4. Thomas BJ, et al. The transdermal revolution. Drug Discovery Today 2004; 16: 697–703.
5. Fait T. Transdermální a perkutánní terapeutické systémy. Mod Gynek Porod 2004; 13(2 Suppl): 327–331.
6. Cibula D. Kontinuální schéma užívání – významný trend v kombinované hormonální kontracepci. Čes. Gynek. 2006; 71(1): 66–69.
7. Speroff L. Je transdermální kontracepční náplast častější příčinou tromboembolické nemoci než perorální kontracepce? Komentář: Halaška M. Gynek. po prom. 2008; 8(3): 29–32.
8. Heger-Mahn D, et al. Combined ethinylestradiol/gestodene contraceptive patch: two-center, open-label study of ovulation inhibition, acceptability and safety over two cycles in female volunteers. Eur J Contracept Reprod Health Care 2004; 9(3): 173–181.
9. Duijkers I, et al. A comparative study on the effects of a contraceptive vaginal ring NuvaRing and an oral contraceptive on carbohydrate metabolism and adrenal and thyroid function. Eur J Contracept Reprod Health Care 2004; 9(3): 131–140.
10. Bjarnadóttir RI, et al. Comparison of cycle control with a combined contraceptive vaginal ring and oral levonorgestrel/ethinylestradiol. Am J Obst Gynecol 2002; 186(3): 389–395.
11. Alexander NJ, et al. Why consider vaginal drug administration? Fertil Steril 2004; 82(1): 1–12.
12. Verhoeven CHJ, et al. The combined contraceptive vaginal ring, NuvaRing, and tampon co-usage. Contraception 2004; 69(3): 197–199.
13. Merkatz R, et al. Preliminary results from a phase III study of the nestorone/ethinyl estradiol contraceptive vaginal ring: a new, long acting (one year) user controlled contraceptive method. 11th Congress of European society for contraception and reproductive health care, Haag, May 2010, present.
14. De Melo N, et al. Satisfaction and non-contraceptive benefits with NuvaRing, a novel vaginal combined contraceptive method in a clinical experience program in Brazil. Eur J Contracept Reprod Health Care 2004; 9(Suppl 1): 98.
15. Chen JH, et al. The comparative trial of TCu 380A IUD and progesterone-releasing vaginal ring used by lactating women. Contraception 1998; 57(6): 371–379.
16. Ji G, et al. Clinical investigation of a low-dose levonorgestrel-releasing vaginal ring. Fertil Steril 1986; 46(4): 626–630.
17. Kaunitz AM. Injekční kontracepce. Komentář: Čepický P. Gynek. po prom. 2002; 2(2): 37–45.
18. Líbalová Z. Parenterální formy hormonální kombinované antikoncepce. Mod Gynek Porod 2004; 13(2 Suppl): 332–335.
19. Štěrba R. Vývoj nových gestogenů a možnosti jejich využití v praxi. Farmakoterapeutické zprávy Spofa. Praha 1969, Suppl 1.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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