Sobotka R, Hanuš T, Zemanová M. Principal value of surgical therapy in the renal cell cancer, chances of the biological treatment
Authors:
Roman Sobotka 1; Tomáš Hanuš 1; Milada Zemanová 2
Authors‘ workplace:
Univerzita Karlova v Praze, 1. lékařská fakulta, Urologická klinika VFN
1; Univerzita Karlova v Praze, 1. lékařská fakulta, Onkologická klinika VFN
2
Published in:
Čas. Lék. čes. 2011; 150: 156-160
Category:
Review Article
Overview
Renal cell cancer belongs to the most malignant tumours in urology; the incidence in the Czech Republic is highest world. Surgical treatment is the first method of choice both in localized and metastatic renal cell cancer due to its chemo and radioresistance. Cytoreductive nephrectomy in case of metastatic renal cell cancer can prolong the overall survival. Lymfogenic propagation is rare, but involvement of lymphatic retroperitoneal nodes is the most unfavourable risk factor. Patients with vein tumour thrombus profit from the radical surgical treatment; the most important thing is the removal of whole tumour thrombus. Miniinvasive methods in treatment of renal cell cancer are getting more and more popular nowadays. Partial nephrectomy is a method of choice in the treatment of small suitable localised renal cell cancers. Adjuvant therapy is not indicated in localised renal cell cancer. Immunotherapy was the most convenient method of treatment generalised renal cell cancer in the last decade of 20th century. Understanding of signalling pathways for growth factors in angiogenesis was the cue for targeted therapy. This method pushes back immunotherapy. Unfortunately targeted therapy fails to cure patients with generalized renal cell cancer; it can only stabilize disease and prolong the overall survival.
Key words:
renal cell cancer, radical nephrectomy, nephron sparing surgery, cytoreductive nephrectomy, tumour thrombus, metastazectomia, immunotherapy, targeted therapy, PERCY Duo, PERCY Quatro.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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