Pharmacogenetics in cardiovascular diseases therapy – treatment according guidelines or according the individual requirement?
Authors:
Jan Bultas
Authors‘ workplace:
Univerzita Karlova V Praze, 3. lékařská fakulta, Ústav farmakologie
Published in:
Čas. Lék. čes. 2010; 149: 476-481
Category:
Review Article
Overview
In clinical practice the individual response to a drug represents a great problem. Many of us experienced a situation when the drug effect declined or drug-related toxic reaction occurred. The typical example is the variation of optimal warfarin dosage. The main cause of interindividual differences in the drug response is the polymorphism in drug resorption and elimination systems, enzymes responsible for drug biotransformation, target receptors or signal molecules. The individualized drug therapy requires physicians to be oriented in main causes of pharmacokinetic and pharmacodynamic variations and be able to predict accurately the individual drug response.
Key words:
polymorphism, clopidogrel, warfarin, betablockers, drug metabolism, transport protein, pharmacogenetics.
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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