Pharmacogenetic aspects of current pharmacotherapy
Authors:
Ondřej Slanař 1,2; Tomáš Zima 2
Authors‘ workplace:
Univerzita Karlova v Praze, 1. lékařská fakulta, Farmakologický ústav
1; Univerzita Karlova v Praze, 1. lékařská fakulta, Ústav klinické biochemie a laboratorní diagnostiky
2
Published in:
Čas. Lék. čes. 2010; 149: 472-475
Category:
Review Article
Overview
Pharmacogenetics is a specific area of personalized medicine. Pharmacogenetic testing is in the ideal situation conducted prior to the initiation of pharmacotherapy in order to increase efficacy or to minimize risk of toxicity in predisposed patients. There are only few examples of such prospective pharmacogenetics in real praxis so far. We summarize examples of pharmacogenetic tests used in praxis. The pharmacogenetic testing should be applied whenever there is evidence that such test can bring benefit over the therapy without such guidance. However, for most of the drugs on the market, reliable evidence is missing and it will take a lot of effort to obtain pharmacogenetic data for future wider use of these tests.
Key words:
pharmacogenetics, personalized medicine, individualized treatment.
Sources
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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