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Alveolar echinococcosis – a new emerging disease?


Authors: L. Hozáková-Lukáčová 1;  L. Kolářová 2;  L. Rožnovský 1;  I. Hiemer 3;  L. Denemark 4;  R. Čuřík 5;  J. Dvořáčková 6
Authors‘ workplace: IPVZ Praha, NRL pro tkáňové helmintózy ;  Fakultní nemocnice Ostrava, Klinika infekčního lékařství 1;  Univerzita Karlova v Praze, 1. lékařská fakulta, III. klinika infekčních a tropických nemocí VFN 2;  Slezská nemocnice v Opavě, Infekční oddělení 3;  Univerzita Karlova v Praze, 3. lékařská fakulta, Chirurgická klinika FNKV 4;  Bioptická laboratoř s. r. o., Plzeň 5;  Fakultní nemocnice Ostrava, Ústav patologie 6
Published in: Čas. Lék. čes. 2009; 148: 132-136
Category: Case Report

Overview

Alveolar echinococcosis is a rare zoonotic disease caused by the cestode larval stages of Echinococcus multilocularis. The Larva develops as a tumour like cyst (hydatid). Due to a slow cyst development, the early stage of the infection is always asymptomatic and the clinical symptoms develop after years later. In the Czech Republic the disease is still very rare. Only one alveolar echinococcosis case was reported 30 years ago. However, new alveolar echinococcosis cases occurred during last two years and some of them indicate autochtonic character of the transmission. With regard to the recent increasing risk of infection with E. multilocularis in Central Europe, we present two case reports of alveolar echinococcosis in a 33-year old woman and a 24-year old man. The reports show diagnostic process and therapy of the infection.

Key words:
Echinococcus multilocularis, alveolar echinococcosis, diagnosis, chemotherapy, surgery.


Sources

1. Eckert J, Deplazes P. Biological, Epidemiological, and Clinical Aspects of Echinococcosis, a Zoonosis of Increasing Concern. Clin Microb Rev 2004; 17: 107–135.

2. Torgerson P, Schweiger A, Deplazes P, et al. Alveolar echinococcosis: From a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years. J Hepatol 2008; 49: 72–77.

3. Skalický T, Třeška V, Martínek K, et al. Alveolární hydatidóza – vzácný případ jaterního postižení v České republice. Čes Slov Gastroent Hepatol 2008; 62: 30–33.

4. Kolářová L. Echinococcus multilocularis: new epidemiological insights in Central and Easter Europe. Helmintologia 1999; 36: 193–200.

5. Kolářová L, Červený J, Martínek K. The occurence of Echinococcus multilocularis in Central and Eastern Europe. Helminthologia 1998; 35: 165–166.

6. Martínek K, Kolářová l, Červený J. Echinococcus multilocularis in carnivores from the Klatovy district of the Czech Republic. J Helminthol 2001; 75: 61–66.

7. Jiang C, Don M, Jones M. Liver alveolar echinococcis in China: Clinical aspect with relative basic research. World J Gastroenterol 2005; 11: 4611–4617.

8. Amman R, Eckert J. Cestodes: Echinococcus. Gastroenterol Clin N Am 1996; 25: 655–689.

9. Kern P, Bardonnet K, Renner E, et al. European Echinococcosis registry: human alveolar echinococcosis, Europe, 1982–2000. Emerg Infect Dis 2003; 9: 133–139.

10. Bresson-Hadni S, Koch S, Beurton I, et al. Primary disease recurrence after liver transplantation for alveolar echinoccosis: long term evaluation in 15 patients. Hepatology 1999; 30: 587–564.

11. Pawlowski ZS, Eckert J, Vuitton DA, et al. Echinococcosis in humans: clinical aspects, diagnosis and treatment. In: Eckert J, Gemmell MA, Meslin F-X, Pawlowski ZS. WHO/OIE Manual on echinococcosis in humans and animals: a public health problem of global concern. Paris: Office Internationales des Epizooties 2001; 20–71.

12. McManus D, Zhang W, Li J, Bartley PB. Echinococcosis. Lancet 2003; 362: 1295–1304.

13. Reuter S, Jensen B, Buttenschoen K, Kern P. Benzimidazoles in the treatment of alveolar echonococcosis: a comparative study and review of the literature. J Antimicrob Chemotherapy 2000; 46: 451–456.

14. Hemphill A, Spicher M, Stadelmann B, Mueller J, et al. Innovative chemotherapeutical treatment for alveolar and cystc echinococcosis. Parasitology 2007; 134: 1657–1670.

15. Romig T, Dinkel A, Mackenstedt U. The present situation of echinococcosis in Europe. Parasitol Int 2006; 55: 187–191.

16. Ehrhardt AR, Reuter S, Buck AK, et al. Assessment of disease activity in alveolar echinococcosis: a comparison of contrast enhanced ultrasound, three-phase helical CT and [18F] fluorodeoxyglucose positron emission tomography. Abdom Imaging 2007; 32: 730–736.

17. Stumpe KDM, Renner-Schneiter EC, Kuenzle AK, et al. F-18-Fluorodeoxyglucose Positron-Emission Tomography of Echinococcus multilocularis. Liver Lesions: Prospective Evaluation of its Valu efor diagnosis and Follow-up during Benzimidazole Therapy. Infection 2007; 35: 11–18.

18. Kern P, Frosch P, Helvit M, et al. Diagnosis of Echinococcus multilocularis infection by reverse-transcription polymerace Chin resction. Gastroeneterology 1995; 109: 596–600.

19. Myjak P, Nahorski W, Pietkiewicz H, et al. Molecular confirmation of human alveolar echinococcosis in Poland. Clin Infect Dis 2003; 37: 121–125.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
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