Is Current Treatment of Primary and Secondary Amyloidosis Effective?
Authors:
R. Ryšavá; I. Špička; M. Merta; V. Tesař; M. Trněný
Authors‘ workplace:
I. interní klinika 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2003; : 370-372
Category:
Overview
Background.
Retrospective study about results of treatment of patients (pts) with primary (AL) and secondary (AA)amyloidosis is given. 31 pts with systemic forms of amyloidosis have been treated and followed-up in our departmentsince 1993.Methods and Results. 6 men and 11 women were in the AL group with the mean age of 59 years. Multiple myelomawas diagnosed in 9 pts, monoclonal gammapathy of undetermined significance (MGUS) was found in 8 pts. Thekidneys were affected in all pts, heart in 59 % of pts, liver, joints and skin in 26 % of pts and polyneuropathy wasdetected only in 1 pt. Progression of renal insufficiency with decrease of glomerular filtration rate (GFR) was detectedin the AL group at the end of follow-up period comparedwith the initial level (p
Key words:
AL amyloidosis, AA amyloidosis, MGUS, paraprotein, ASCT, immunosuppressive drugs.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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