Authors: R. Ryšavá; I. Špička; M. Merta; V. Tesař; M. Trněný Authors‘ workplace: I. interní klinika 1. LF UK a VFN, Praha Published in: Čas. Lék. čes. 2003; : 370-372 Category:
Background. Retrospective study about results of treatment of patients (pts) with primary (AL) and secondary (AA)amyloidosis is given. 31 pts with systemic forms of amyloidosis have been treated and followed-up in our departmentsince 1993.Methods and Results. 6 men and 11 women were in the AL group with the mean age of 59 years. Multiple myelomawas diagnosed in 9 pts, monoclonal gammapathy of undetermined significance (MGUS) was found in 8 pts. Thekidneys were affected in all pts, heart in 59 % of pts, liver, joints and skin in 26 % of pts and polyneuropathy wasdetected only in 1 pt. Progression of renal insufficiency with decrease of glomerular filtration rate (GFR) was detectedin the AL group at the end of follow-up period comparedwith the initial level (p
Key words: AL amyloidosis, AA amyloidosis, MGUS, paraprotein, ASCT, immunosuppressive drugs.
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