Authors: J. A. Hubáček 2; P. Stávek 2; J. Piťha 2; Z. Škodová 1; R. Poledne 2 Authors‘ workplace: Laboratoř pro výzkum aterosklerózy IKEM, Praha 2Centrum experimentálního výzkumu chorob srdce a cév, Praha 1 Published in: Čas. Lék. čes. 2003; : 174-176 Category:
Background. High plasma levels of C-reactive protein (involved in unspecific host defence) have been described asindependent risk factor of atherosclerosis. The possible association has been analysed between the CD14 C-159→Tpolymorphism and plasma level of CRP.Methods and Results.With the PCR and subsequent restriction analysis we have evaluated C-159→T polymorphismin the CD14 gene of 166 representatively selected male Caucasians with known plasma level of CRP. The CRP wasmeasured immunologically. A significantly higher (p 2.19 mg/l (31.9 %, 15 out of 47) has been detected when comparedto the group with plasma level of CRP lower than 2.18 mg/l (11.9 %, 5 out of 42).Conclusions. CD14 C-159→T polymorphism could be the first described genetic marker associated with plasmalevel of C-reactive protein.
Key words: CD14 receptor, polymorphism, C-reactive protein.
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