IGFBP-1 and its Protective Role in the Pathogenesis of Microangiopathy in Type 1 Diabetes
Authors:
M. Kršek; M. Prázný; J. Škrha; V. Justová; Z. Lacinová
Authors‘ workplace:
III. interní klinika 1. LF UK a VFN, Praha
Published in:
Čas. Lék. čes. 2001; : 234-237
Category:
Overview
Background.
The role of IGF-I/IGFBP’s system in the pathogenesis of diabetic vascular complications is widely discussed in the literature. We studied the influence of this system on microvasculare in patients with type 1 diabetes with respect to the effect of IGFBP-1.Methods and Results. 17 patients with type 1 diabetes were included in the study. We examined IGF-I, IGFBP-1 and IGFBP-3 serum levels, parameters of compensation of diabetes and basic values of lipid metabolism. The function of microvasculature was examined using the laser-Doppler system Periflux. We didn’t found any relation between the total IGF-I serum levels, parameters of lipid metabolism or level of diabetes compensation and the degree of impairment of the function of microcirculatoin. IGFBP-1 serum levels positively correlated with the peak perfusion in thermal hyperaemia (r=0.39; p
Key words:
Type 1 diabetes, microangiopathy, IGF-I, IGFBP-1, IGFBP-3, laser-doppler fluxmetry.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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