#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Transcription Factors Rel/NF-kB and their Biological Functions


Authors: K. Kaňková;  B. Vojtěšek;  D. Valík
Authors‘ workplace: Ústav patologické fyziologie LF MU, Brno Oddělení buněčné a molekulární onkologie Masarykova onkologického ústavu, Brno Oddělení biochemie Masarykova onkologického ústavu, Brno
Published in: Čas. Lék. čes. 2001; : 163-167
Category:

Overview

The gene family of ubiquitous transcriptional factors Rel/NF-kB participates in several critical cellular events ultimately influencing the fate of a cell. In the cytoplasm of all eukaryotic cells, the Rel/NF-kB proteins occur bound to their inhibitors, the IkB proteins. When stimulated, they become phosphorylated and degraded by 26S proteasom releasing Rel/NF-kB. Active Rel/NF-kB heterodimers then enter the nucleus, bind to a -kB coupling element and start transcription of kB-regulated array of genes involved in immune, antiapoptotic and inflammatory events. Part of the pharmacological effects of glucocorticoids, acetylosalicylic acid an ibuprofen may stand on influencing the Rel/NF-kB pathway. New compounds with cytotoxic and immunomodulatory properties acting specifically on the cascade of Rel/NF-kB signaling system are expected to be synthesized.

Key words:
Rel/NF-signal system, tumorogenesis, apoptosis, Myc protein, Bcl-3 gene, p52 protein, p300-CREB co complex, virus , stress, environmental contaminants, cytotherapy, steroids.

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#