Plasma Concentration of Lp(a) in Myocardial Infarction Patients is not Influenced by Apolipoprotein E Gene Polymorphism
Authors:
J. A. Hubáček; P. Stávek; J. Piťha; Z. Škodová; R. Poledne
Authors‘ workplace:
Kardiocentrum, Institut klinické a experimentální medicíny, Praha
Published in:
Čas. Lék. čes. 2001; : 332-334
Category:
Overview
Background.
We evaluated a two risk factors of atherosclerosis development, apolipoprotein E genotype and plasma level of Lp(a), and their association in Czech population.Patients and Controls. Apo E and Lp(a) have been determined in the group of 109 men with premature myocardial infarction and compared with the population samples (301 men for apo E polymorphism and 112 men for Lp(a) evaluation).Methods and Results. Apo E gene polymorphism was analysed by PCR with subsequent restriction analysis of the PCR product. Lp(a) concentration was measured enzymatically using the IMMUNO set. The frequency of alleles of apo E genotype in myocardial infarction patients did not significantly differ from that found in the control group. The distribution of the Lp(a) concentrations in MI patients was shifted to higher levels than in population sample (p
Key words:
apolipoprotein E, Lp(a), polymorphism, myocardial infarction.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain managementArticle was published in
Journal of Czech Physicians
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