Authors: J. Hrudová; A. Linhart; V. Vondráček; J. Humhal; F. Holm; M. Jáchymová; J. Ort; Z. Marečková; K. Horký Authors‘ workplace: II. interní klinika 1. LF UK a VFN, Praha Published in: Čas. Lék. čes. 2000; : 74-78 Category:
Background. While the effect of neurohormones is often studied in congestive heart failure, their role in aorticstenosis needs to be elucidated.Methods. 54 consecutive patients with symptomatic aortic stenosis without overt heart failure were studied at theage of 64.4±9.3 yrs with echocardiography, x-ray and catheterization. Levels of circulating atrial natriuretic factorendothelin-1, catecholamines, plasma renin activity, immunoreactive insulin and C-peptide were assessed, relatedto hemodynamic data and compared to those in 23 healthy controls, aged 59.2±12.8 yrs.Results. Patients had significantly higher plasma levels of endothelin-1 (z-value 0.64±1.19, p=0.019), atrialnatriuretic factor (z-value 2.46±2.46, p
Key words: aortic stenosis, left ventricular hypertrophy, neurohormones, endothelin-1, pulmonary hypertension
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