Blood Rheology During Pulsatile Pharmacomechanical and Local Continual Thrombo-lysis

Overview

Background.
The aim of the work was to find out whether the controlled administration of a thrombolytic directlyinto the arterial occlusion could prevent formation of the systemic lytic state, which may result in distant bleedingcomplications.Methods and Results. In patients subjected to pulsatile pharmacomechanical (94 patients) and local continualthrombolysis (74 patients) changes in blood and plasma viscosity, coagulation tests, fibrinogene levels and someother parameters were investigated.Conclusions. Pulsatile pharmacomechanical thrombolysis, similarly to other forms of thrombolysis, is accompa-nied with systemic lytic state and the risk of unwanted resorption of the hemostatic thrombosis. Urokinazeadministration brings about regress of systemic changes, which is similar to the use of either tested thrombolyticadministration. As treatment by the continual thrombolysistakes is approximately 40 times longer, the risk of systemiclytic state and bleeding complication growths.

Key words:
blood viscosity, urokinaze, local thrombolysis, ischaemic disease of the lower limbs.