Significance of Serum Cystatine C Levels Examination in PaediatricPatients with the Renal Impairment

Overview

. Serum level of cystatin C (MW 13 000) depends on the glomerular filtration and on the productionby nucleated cells. S-cystatin C was proposed as a better glomerular filtration rate marker than serum creatinine orcreatinine clearance. Possibilite to avoid urine collection in children is another important advantage. The aim of thestudy was to estimate reliability of the test in the kidney transplant paediatric patients.Methods and Results. We measured cystatin C on Monarch 2000 IL by particle-enhanced turbidimetric assayusing commercial kit provided by DAKO. We analysed S-cystatin C levels in three groups: 19 children before kidneytransplantation (A), 25 paediatric patients after kidney transplantation (B), 20 children hospitalized on intensive careunit (C). Creatinine was measured by enzymatic method on ADVIA 1650 Bayer. We demonstrated significantcorrelation between S-cystatin C and creatinine levels is both groups A (r2=0.865, P

Key words:
Backgroundcystatin C. glomerular filtration rate, creatinine clearance, kidney transplantation.