Authors: V. Vondra; P. Kraszkó 1; J. Malolepszy 2 Authors‘ workplace: Oddělení tuberkulózy a respiračních nemocí, FN, Motol, Praha, 1 Szentgyörgy Albert Orvostudomany Egyetem, 6772 Deszk, Maďarsko, 2 Klinika Alergologii i chorob wewnetrznych Akademii Medycznej, 50-417 Wroclaw, Polsko Published in: Čas. Lék. čes. 1999; : 78-81 Category:
Background. Recent investigations revealed that in patients with bronchial asthma the same anti-inflammatoryeffect is achieved by inhalation of half the dose of budesonide by a Turbuhaler (i.e. by using corticosteroid in powderform) as by a full dose of beclomethasone driven into the lungs by compressed chlorofluorocarbons (i.e. MDI =pressure dosage inhalator). The objective was to assess whether there is a difference between 12-week treatmentwith budesonide Turbuhaler in a smaller dose of 400 mg/day and treatment with beclomethasone dipropionate MDI800 mg/day.Methods and Results. After an initial two-week period of the 227 patients with mild or medium severe asthmawho had not taken corticosteroids for three months, into the budesonide Turbuhaler group 94 patients were includedand into the beclomethasone MDI group 99 patients.Characteristics: group treated with budesonide (46 men, 48 women, mean age 38 years, FEV 1 78 % of appropriatevalues). Group treated with beclomethasone (51 men, 48 women, mean age 39 years, FEV 1 81.5 % of appropriatevalues).Morning and evening values of the peak expiration rate (PEF) increased significantly after budesonide treatment2x 200 mg/day) as compared with beclomethasone treatment (2x 400 mg/day). Differences of morning PEF betweenbudesonide and beclomethasone: 47 : 28 l/min, p < 0.05, differences of evening PEF: 32 : 10 l/min., p < 0.027.The number of dyspnoic attacks declined after both types of treatment, as well as the amount of inhaledbronchodilatating substances (terbutalin Turbuhaler). The differences between drugs were however not statisticallysignificant.Conclusions. Budesonide Turbuhaler, 400 mg/day when administered to patients with bronchial asthma was atleast as effective as beclomethasone MDI, 800 mg/day. The increase of morning and evening PEF values was afterbudesonide significantly higher than after beclomethasone.
Key words: bronchial asthma, budesonide Turbuhaler, Beclomethasone MDI
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