Cerebral Ischaemia and Possible Neuroprotection from the Aspect of theNeurosurgeon

Overview

Cerebral ischemia is a frequent and dangerous consequence of some cerebrovascular diseases. Ischaemia may beused also electively in the course of neurosurgery. Therefore new possible ways are sought how to reduce the dangerof ischaemia or to prevent it.In the submitted paper some methods of neuroprotection are described and their potential or actual applicabilityin clinical neurosurgery are discussed. In addition to influencing the brain cell and pretentious methods in the sphereof molecular biology and genetics the induction of systemic hypertension supplemented alternatively by othermethods such as hypothermia, the use of mannitol, haemodilution and hypervolaemia seem natural. A higher bloodpressure helps to make leptomeningeal and cortical anastomoses patent and strengthens the collateral circulationfrom marginal zones of ischaemia, penumbra to the ischaemic centre and to prevent thus cerebral infarction.

Key words:
cerebral ischaemia, neuroprotection.