Current view on hepatitis B diagnosis and therapy
Authors:
Petr Husa
Authors‘ workplace:
Klinika infekčních chorob LF MU a FN Brno, pracoviště Bohunice
Published in:
Vnitř Lék 2019; 65(9): 546-551
Category:
Overview
Hepatitis B virus (HBV) infection remains a global public health problem with changing epidemiology due to several factors predominantly vaccination policy and migration. Chronic hepatitis B means the duration of HBV infection for more than 6 months. It is a dynamic process reflecting the interaction between HBV replication and the host immune response and not all patients with chronic HBV infection have chronic hepatitis B. All patients with chronic HBV infection are in increased risk of progression to liver cirrhosis and hepatocellular carcinoma. The long-term administration of potent nucleos(t)ide analogue with high barrier of resistance (tenofovir, entecavir) represents the treatment of choice. Pegylated interferon-α can also be considered in mid to moderate chronic hepatitis B patients.
Keywords:
chronic hepatitis B – entecavir – pegylated interferon-α – tenofovir
Sources
- [European Association for the Study of the Liver]. EASL 2017 Clinical Practice Guidelines on the management of hepatitis B virus infection. J Hepatol 2017; 67(2): 370–398. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jhep.2017.03.021>.
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- EPIDAT. Epidemiologická databáze Státního zdravotního ústavu Praha. Dostupné z WWW: <http://www.szu.cz/publikace/data/infekce-v-cr>.
- Husa P, Šperl J, Urbánek P et al. Doporučený postup diagnostiky a léčby infekce virem hepatitidy B. Gastroent Hepatol 2017; 71(5): 419–437. Dostupné z DOI: <http://dx.doi.org/10.14735/amgh2017419>.
- Husa P, Šperl J, Urbánek P et al. Doporučený postup diagnostiky a léčby infekce virem hepatitidy B. Datum vydání doporučení: září 2017. Klin Mikrobiol Infeck Lek 2017; 23(4): 148–164.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2019 Issue 9
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