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Impact of natriuretic peptides in current clinical practice


Authors: Eva Ganovská 1;  Jindřich Špinar 1,2;  Jiří Pařenica 1,2
Authors‘ workplace: Interní kardiologická klinika LF MU a FN Brno, pracoviště Bohunice, přednosta prof. MUDr. Jindřich Špinar, CSc., FESC 1;  Mezinárodní centrum klinického výzkumu – klinika kardiovaskulárních onemocnění FN u sv. Anny Brno, ředitel Gorazd B. Stonkin, M. D., MSc., Ph. D. 2
Published in: Vnitř Lék 2014; 60(5-6): 474-483
Category: Review

Overview

Natriuretic peptides (NP) have been intensively studied and also used in clinical practice. Their use is important for diagnosis and risk stratification of heart failure, pulmonary embolism and acute coronary syndrome. For the correct interpretation of the results is necessary to know factors, which induce elevation of natriuretic peptides. The article shows an overview of the physiology of the NP, the factors that influence the levels of NP, like heart failure, acute coronary syndrome and pulmonary embolism etc. There is also mentioned possibility of using synthetic derivates of natriuretic peptides in therapy of heart failure.

Key words:
acute coronary syndrome – diabetes mellitus – heart failure – natriuretic peptides – obesity – pulmonary embolism – renal insufficiency


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