Authors: J. Bulas 1; M. Potočárová 1; J. Murín 1; A. Šimková 1; I. Janiga 2 Authors‘ workplace: I. interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika, prednostka doc. MUDr. Soňa Kiňová, PhD. 1; Slovenská technická univerzita Bratislava, Slovenská republika, dekan prof. Ing. Ľubomír Šóoš, PhD. 2 Published in: Vnitř Lék 2012; 58(7 a 8): 190-194 Category: 60th Birthday prof. MUDr. Miroslav Souček, CSc.
Introduction: Increased aortic stiffness belongs into the category of preclinical cardiovascular diseases. It is defined by pathologically increased velocity of carotido-femoral pulse wave velocity (PWVAo). In the group of treated hypertensive patients we measured the aortic pulse wave velocity and augmentation indices with the aim to define some parameters of central hemodynamics and to search for a relationship among them and the central aortic blood pressure.
Patient and methods: We examined a group of 68 nonselected patient with arterial hypertension treated by combination therapy (mean of 3.4 drugs per patient). The arterial stiffness was measured using the Arteriograph-TensioMed, an equipment based on oscillometric principle, detecting the shape of brachial artery pulse by blood pressure cuff. It gives the values of brachial blood pressure, aortic pulse wave velocity, augmentation index, central systolic blood pressure and time indices of heart cycle.
Results: We found a significant correlation of central aortic pressure and augmentation indices to aortic pulse wave velocity (aortic stiffness). These relationships were present despite the ongoing antihypertensive therapy with combination of drugs, as a matter of fact, a part of patients (23 persons) were treated by NO donors (nitrates and molsidomine).
Conclusion: Measurements of central hemodynamic parameters as the augmentation index, central systolic blood pressure or aortic stiffness and indices derived, enable us to better estimate the load of the left ventricle and more precisely evaluate the efficiency of the antihypertensive therapy; their usage in the evaluation of antihypertensive therapy in a broader clinical practice, could improve prognosis of patients with arterial hypertension.
Key words: aortic stiffness – pulse wave velocity – central aortic blood pressure – augmentation index – preclinical cardiovascular diseases
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