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Results of the CRAB II project of the Czech Myeloma Group


Authors: Vladimír Maisnar
Authors‘ workplace: IV. interní hematologická klinika, Fakultní nemocnice a Lékařská fakulta Univerzity Karlovy Hradec Králové
Published in: Geriatrie a Gerontologie 2025, 14, č. 2: 75-79
Category: Original Article
doi: https://doi.org/10.61568/geri/50-6499/20250512/140520

Overview

Multiple myeloma is the second most common hematologic malignancy in the Czech Republic, and its incidence continues to rise. Clinical experience shows that up to half of patients with multiple myeloma begin treatment late due to delayed diagnosis. The original CRAB project by the Czech Myeloma Group was aimed at addressing this issue. The current article summarizes the results of the questionnaire phase of the CRAB II project, which is intended to be followed by a large-scale information campaign about the symptoms of the disease, including recommended diagnostic procedures when a possible connection to this serious condition is suspected. Improving the diagnosis of multiple myeloma – especially in terms of early detection – and advancing modern treatment approaches to first-line therapy should, in the future, lead to further prolongation and simultaneous improvement of patients’ quality of life.

Keywords:

diagnosis – Multiple myeloma – CRAB project


Sources

1.           Hájek R, Maisnar V, Minařík J, et al. Diagnostika a léčba mnohočetného myelomu. Transfuze Hematol Dnes 2023; 29(Suppl. 2): 1–142.

2.           Rajkumar SV, Dimopoulos MA, Palumbo A, et al. International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 2014; 15(12): e538–
e548.

3.           Arends M, van Dussen L, Biegstraaten M, et al. Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature. Br J Hematol 2013; 161(6): 832–842.

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