Indapamide induced hyponatremia in an 83 year old patient

Authors: H. Lacmanová;  T. Richter;  E. Topinková
Published in: Geriatrie a Gerontologie 2018, 7, č. 1: 40-43
Category: Case Reports


Hyponatremia is one of the most common electrolyte disorders in old age. As age advances the occurrence of hyponatremia risk factors increases. Thiazide and thiazide-like diuretics and antidepressants belong to drug classes with the highest incidence of adverse drug reaction – hyponatremia. In the case study we present an 83 years old female with indapamide-induced severe symptomatic hyponatremia with hypoosmolar hypovolemia which led to hospitalization. In thorough diagnostic process we were able to identify several other factors predisposing to hyponatremia while on diuretics – concomitant treatment with SSRI, acute infection, diabetes mellitus, chronic malnutrition. Treatment of hyponatremia – mainly stopping hyponatremia-inducing drugs, re-hydration with isoosmolar fluids, correction of hypomagnesemia, antibiotic treatment of infection led to clinical status improvement and increase of S-Na values. However, even after 4 weeks of treatment serum – Na concentrations did not return to the normal range.

drug-induced hyponatremia – elderly – case study


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