Malignant tumors of the oral cavity in general practice
Authors:
S. Adamcová 1; J. Štembírek 1,2,3; J. Belobradová 1,2; A. Krayzel 1,2; T. Blažek 4; J. Mičaník 5; L. Pliska 6; P. Hurník 7; M. Bereš 8; J. Stránský 1,2; O. Res 1,2; D. Gedeonová 1,2
Authors‘ workplace:
Fakultní nemocnice Ostrava, Klinika ústní, čelistní a obličejové chirurgie
1; Ostravská univerzita, Lékařská fakulta, Katedra zubního lékařství
2; Akademie věd Brno, Ústav živočišné fyziologie a genetiky, Laboratoř molekulární morfogeneze
3; Fakultní nemocnice Ostrava, Onkologická klinika
4; Fakultní nemocnice Ostrava, Ústav radiodiagnostický
5; Fakultní nemocnice Ostrava, Centrum plastické chirurgie a chirurgie ruky
6; Fakultní nemocnice Ostrava, Ústav klinické a molekulární patologie a lékařské genetiky
7; Univerzita P. J. Šafárika v Košiciach, Klinika stomatológie a maxilofaciálnej chirurgie, SR
8
Published in:
Prakt. Lék. 2026; 106(3): 125-130
Category:
Case Report
Overview
Malignant tumours of the oral cavity represent a serious group of diseases whose prognosis is closely linked to the timeliness of diagnosis. The general practitioner can make a significant contribution to the early detection of suspicious lesions and to shortening the diagnostic delay within the framework of preventive examinations. This paper presents three case reports of patients with squamous cell carcinoma of the oral cavity, illustrating different clinical scenarios: late tumour detection, long-term follow-up of a potentially malignant lesion with subsequent transformation, and a recurrent aggressive disease course. The case reports emphasize the importance of systematic intraoral and extraoral examination, correct interpretation of non-healing mucosal lesions, and timely biopsy or referral to a specialized centre. Early diagnosis is associated with less burdensome treatment, better quality of life, and a more favourable prognosis for patients.
Keywords:
early diagnosis – Primary care – overall survival – oral squamous cell carcinoma – oral cavity cancer – general dental practitioner
Sources
1. Bagan J, Sarrion Perez G, Jimenez Y. Oral cancer: clinical features. Oral Oncol. 2010; 46(6): 414–417.
2. Bosetti C, Carioli G, Santucci C, et al. Global trends in oral and pharyngeal cancer incidence and mortality. Int J Cancer 2020; 147(4): 1040–1049.
3. Fernández-Martínez NF, Petrova D, Špacírová Z, et al. The duration of intervals on the oral cancer care pathway and implications for survival: a systematic review and meta-analysis. Front Public Health 2023; 11 : 1183244.
4. Holmes JD, Dierks EJ, Homer LD, Potter BE. Is detection of oral and oropharyngeal squamous cancer by a dental health care provider associated with a lower stage at diagnosis? J Oral Maxillofac Surg. 2003; 61(3): 285–291.
5. Kowalski LP, Franco EL, Torloni H, et al. Lateness of diagnosis of oral and oropharyngeal carcinoma: factors related to the tumour, the patient and health professionals. Eur J Cancer B Oral Oncol. 1994; 30B(3): 167–173.
6. Imbesi Bellantoni M, Picciolo G, Pirrotta I, et al. Oral cavity squamous cell carcinoma: an update of the pharmacological treatment. Biomedicines 2023; 11(4): 1112.
7. Murphy CT, Galloway TJ, Handorf EA, et al. Survival impact of increasing time to treatment initiation for patients with head and neck cancer in the United States. J Clin Oncol. 2016; 34(2): 169–178.
8. National institute for health and care excellence. Suspected cancer: recognition and referral. NICE Guideline NG12 [online]. London: NICE, 2015. Dostupné z: https://www.nice.org.uk/guidance/ng12 [cit. 2026-05-29].
9. Romero JMS, Mallah N, Varela-Centelles PI, et al. Primary care referral delays in oral cancer diagnosis: a meta-analysis. Oral Dis. 2025; 31(7): 2148–2159.
10. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 2009; 45(4–5): 309–316.
11. Mashberg A. Diagnosis of early oral and oropharyngeal squamous carcinoma: obstacles and their amelioration. Oral Oncol. 2000; 36(3): 253–255.
12. Allison P, Locker D, Feine JS. The role of diagnostic delays in the prognosis of oral cancer: a review of the literature. Oral Oncol. 1998; 34(3): 161–170.
13. Mignogna M, Fedele S, Russo LL. The World Cancer Report and the burden of oral cancer. Eur J Cancer Prev. 2004; 13(2): 139–142.
14. Sankaranarayanan R, Ramadas K, Thomas G, et al. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trial. Lancet 2005; 365(9475): 1927–1933.
15. Mignogna MD, Fedele S. Oral cancer screening: 5 minutes to save a life. Lancet 2005; 365(9475): 1905–1906.
16. Campo-Trapero J, Cano-Sánchez J, Palacios-Sánchez B, et al. Update on molecular pathology in oral cancer and precancer. Anticancer Res. 2008; 28(2B): 1197–1205.
17. Fedele S. Diagnostic aids in the screening of oral cancer. Head Neck Oncol. 2009; 1 : 5.
18. Tran Q, Maddineni S, Arnaud EH, et al. Oral cavity cancer in young, non-smoking, and non-drinking patients: a contemporary review. Crit Rev Oncol Hematol. 2023; 190 : 104112.
19. Yan EZ, Wahle BM, Nakken ER, et al. No survival benefit in never-smoker never-drinker patients with oral cavity cancer. Head Neck. 2023; 45(3): 567–577.
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General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2026 Issue 3
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