Effect of selenium nanoparticles on pathogenic bacterial cultures and yeasts
Authors:
D. Hegerová 1,2; K. Číhalová 1,2; P. Sedláček 3; R. Veselý 4; P. Kopel 1,2; V. Adam 1,2; R. Kizek 5
Authors‘ workplace:
Mendelova univerzita v Brně
Ústav chemie a biochemie
Vedoucí: prof. RNDr. Vojtěch Adam, Ph. D.
1; Vysoké učení technické v Brně
Středoevropský technologický institut
Vedoucí: prof. Ing. Radimír Vrba, CSc.
2; MedicProgress, a. s., Olomouc
Ředitel: Ing. Pavel Sedláček
3; Klinika traumatologie
Lékařská fakulta Masarykovy univerzity a Úrazová nemocnice v Brně
Vedoucí: prof. MUDr. Miloš Janeček, CSc.
4; Lékařská univerzita Wroclaw
Vedoucí: prof. Dr. Halina Milnerowitz, Ph. D.
5
Published in:
Prakt. Lék. 2016; 96(1): 18-24
Category:
Of different specialties
Overview
Issue of bacterial and yeast infections with complicated course of treatment due to resistance of agents of these diseases are a frequent topic of research in the field of human and veterinary medicine. In this study, we focused on the study of selenium nanoparticles effect in the form of a gel-like complex with a polymer substance Cekol (SeNPs) as possible alternative to antibiotic drugs, in the elimination of bacterial and yeast infections. Testing of complex was carried out on the bacterial and yeast isolates obtained from a cohort of 450 patients from the Department of Traumatology at Trauma Hospital in Brno, from which it was taken always one swab sample from a superficial skin infection and to date have managed to identify in total 74 sub-species of bacterial strains or yeasts. To identify strains and tests of SeNPs microbiological, molecular-biological and mass spectrometry methods were used.
The study demonstrated a significant effect of this product on the bacterial strains and yeasts, regardless of their morphology. The growth of most strains from the file was managed by application of nanoparticles completely eliminated. However, in all cases this growth was at least largely suppressed. Sizes of inhibition zones, which can be regarded as effective (1), ranged from 5–20 mm. Our results describe significant antimicrobial effects based on nanotechnologies, which can be used to reduce the risk of uncontrolled infections in comparison with conventional antibiotic therapy.
Keywords:
bacteria – yeast – pathogenicity – infections – selenium nanoparticles – inhibition
Sources
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General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2016 Issue 1
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