Is obesity a risk factor of selected tumours?
Authors:
D. Šubová 1; K. Azeem 1; J. Ševčíková 1; D. Horáková 1; J. Vlčková 1; H. Tomášková 2; V. Žídková 1; H. Kollárová 1
Authors‘ workplace:
Univerzita Palackého v Olomouci Lékařská fakulta Ústav preventivního lékařství Přednosta: doc. MUDr. Helena Kollárová, Ph. D.
1; Ostravská univerzita v Ostravě Lékařská fakulta Ústav epidemiologie a ochrany veřejného zdraví Vedoucí: prof. MUDr. Vladimír Janout, CSc.
2
Published in:
Prakt. Lék. 2014; 94(1): 16-21
Category:
Of different specialties
Overview
Tumours are the second most frequent cause of death in the Czech Republic. Obesity is given in connection with some tumours and it represents important preventable cause of tumour deaths in population. The aim of the study was to appoint an association between selected types of tumours and obesity and the evidence based medicine compare the results of our studies with published data. The article shows outcomes of three case and control studies. Association between obesity and kidney cancer was found by logistic regression analysis, with OR = 1.44 (95% CI 0.91–2.28). Statistically significant inverse association of overweight and obesity and oesophagus cancer was found using the crude OR = 0.38 (95% CI 0.21–0.68) for overweight and OR = 0.22 (95% CI 0.09–0.51) for obesity. Causal link between overweight and obesity and pancreas cancer was not found.
Keywords:
obesity – malignant tumours – study
Sources
1. Baranova AV. Adipokine genetics: unbalanced protein secretion by human adipose tissue as a cause of the metabolic syndrome. Genetika 2008; 44(10): 1338–1355.
2. Bergstrom A, Pisani P, Tenet V, et al. Overweight as an avoidable cause of cancer in Europe. Int J Cancer 2001; 91(3): 421-430.
3. Bracci PM. Obesity and pancreatic cancer: overview of epidemiologic evidence and biologic mechanisms. Mol Carcinog 2012; 51(1): 53–63.
4. Cook MB, Greenwood DC, Hardie LJ, et al. A systematic review and meta-analysis of the risk of increasing adiposity on Barrett's esophagus. Am J Gastroenterol 2008; 103(2): 292–300.
5. Corley DA, Kubo A, Zhao W. Abdominal obesity and the risk of esophageal and gastric cardia carcinomas. Cancer Epidemiol Biomarkers Prev 2008; 17(2): 352–358.
6. Engel LS, Chow WH, Vaughan TL, et al. Population attributable risks of esophageal and gastric cancers. J Natl Cancer Inst 2003; 95(18): 1404–1413.
7. Ferlay J, Shin HR, Bray F, et al. GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 10 [online]. Lyon, France: International Agency for Research on Cancer; 2010. [cit. 2012-08-08]. Dostupné na: http://globocan.iarc.fr.
8. Fiala J, Brázdová Z. Výživa v prevenci nádorů. Klinická onkologie 2000; zvláštní číslo: 8–16.
9. Flaherty KT, Fuchs CS, Colditz GA, et al. A prospective study of body mass index, hypertension, and smoking and the risk of renal cell carcinoma (United States). Cancer Causes Control 2005; 16(9): 1099–1106.
10. Hajer GR, van Haeften TW, Visseren FL. Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. Eur Heart J 2008; 29(24): 2959–2971.
11. Hampel H, Abraham NS, El-Serag HB. Meta-analysis: obesity and the risk for gastroesophageal reflux disease and its complications. Ann Intern Med 2005; 143(3): 199–211.
12. Hlubik P. Obezita – nemoc, rizikový faktor. Interní Med 2002; 4(8): 396–398.
13. Hsu CC, Chow WH, Boffetta P, et al. Dietary risk factors for kidney cancer in Eeastern and Central Europe. Am J Epidemiol 2007; 66(1): 62–70.
14. Chow WH, Gridley G, Fraumeni JF, et al. Obesity, hypertension, and the risk of kidney cancer in men. N Engl J Med 2000; 343(18): 1305–1311.
15. Key TJ, Schatzkin A, Willett W, et al. Diet, nutrition and prevention of cancer. Publ Health Nutr 2004; 7(1A): 187–200.
16. Kubo A, Corley DA. Body mass index and adenocarcinomas of the esophagus or gastric cardia: a systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev 2006; 15(5): 872–878.
17. Lagergren J. Controversies surrounding body mass, reflux, and risk of oesophageal adenocarcinoma. Lancet Oncol 2006; 7(4): 347–349.
18. Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol 2006; 176(6Pt1): 2353–2358.
19. Matoulek M. Výskyt obezity a jejich komplikací v České republice. Vnitř. Lék. 2010; 56(10): 1019–1027.
20. Obezita.cz. Obezita v ČR i ve světě [on line] [cit. 2013-06-14]. Dostupný na: http://www.obezita.cz /obezita/v-cr-a-ve-svete/.
21. Olson SH, Kurtz RC. Epidemiology of pancreatic cancer and the role of family history. J Surg Oncol 2013; 107(1): 1–7.
22. Pischon T, Lahmann PH, Boeing H, et al. Body size and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC). Int J Cancer 2006; 118(3): 728–738.
23. Pischon T, Nöthlings U, Boeing H. Obesity and cancer. Proc Nutr Soc 2008; 67(2): 128–145.
24. Rubenstein JH, Taylor JB. Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux. Aliment Pharmacol Ther 2010; 32(10): 1222–1227.
25. Samanic C, Chow WH, Gridley G, et al. Relation of body mass index to cancer risk in 362,552 Swedish men. Cancer Causes Control 2006; 17(7): 901–909.
26. Scélo G, Brennan P. The epidemiology of bladder and kidney cancer. Nat Clin Pract Urol 2007; 4(4): 205–217.
27. Smith M, Zhou M, Whitlock G, et al. Esophageal cancer and body mass index: results from a prospective study of 220,000 men in China and a meta-analysis of published studies. Int J Cancer 2008; 122(7): 1604–1610.
28. Stránský M. Potraviny, výživa, tělesná aktivita a prevence rakoviny: globální perspektiva. Interní Med 2009; 11(3): 142–145.
29. Ústav zdravotnických informací a statistiky ČR. Novotvary 2010 ČR. Praha: ÚZIS; 2013.
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General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2014 Issue 1
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