Helicobacter pylori infection and immune thrombocytopenic purpura – a case report
Authors:
L. Raida
Authors‘ workplace:
Hemato-onkologická klinika
; Přednosta: Prof. MUDr. Karel Indrák, DrSc.
; Lékařská Fakulta Univerzity Palackého a Fakultní nemocnice Olomouc
Published in:
Prakt. Lék. 2013; 93(2): 63-66
Category:
Case Report
Overview
A role of Helicobacter pylori infection in the etiopathogenesis of immune thrombocytopenic purpura is still investigated and discussed. The infection of Helicobacter pylori in 58-years old female with severe thrombocytopenia and the clinical manifestation of cholecystitis was confirmed by antigen detection in stool. The regression of cholecystitis as well as the normalization of platelets count were achieved with standard eradication therapy. Presented case report is an example of immune thrombocytopenia induced by Helicobacter pylori infection with dominating extragastric manifestation.
Keywords:
immune thrombocytopenic purpura – Helicobacter pylori – gastritis – cholecystitis – eradication therapy
Sources
1. Amedei A, Cappon A, Codolo G, et al. The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responses. J Clin Invest 2006; 116: 1092–1101.
2. Asahi N, Kuwana M, Suzuki H, et al. Effects of a Helicobacter pylori eradication regimen on anti-platelet autoantibody response in infected and uninfected patients with idiopathic thrombocytopenic purpura. Haematologica 2006; 91: 1436–1437.
3. Bureš J, Kopáčová M, Koupilová I, et al. Epidemiology of Helicobacter pylori Infection in the Czech Republic. Helicobacter 2006; 11: 56–65.
4. Byrne MF, Kerrigan SW, Corcoran PA, et al. Helicobacter pylori binds von Willebrand factor and interacts with GPIb to induce platelet aggregation. Gastroenterology 2003; 124: 1846–1854.
5. Douda T, Bureš J, Rejchrt S. Extragastrická manifestace infekce Helicobacter pylori. Čes. a Slov. Gastroent. a Hepatol. 2008; 62: 274–281.
6. Franchini M, Cruciani M, Mengoli C, et al. Effect of Helicobacter pylori eradication on platelet count in idiopathic thrombocytopenic purpura: a systematic review and meta-analysis. J Antimicrob Chemother 2007; 60: 237–246.
7. Cheng G, Saleh MN, Marcher C, et al. Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet 2011; 377: 393–402.
8. Kuter DJ, Rummel M, Boccia R, et al. Romiplostim or standard of care in patients with immune thrombocytopenia. N Engl J Med 2010; 363: 1889–1899.
9. Leong RW, Sung JJ. Review article: Helicobacter species and hepatobiliary diseases. Aliment Pharmacol Ther 2002; 16: 1037–1045.
10. McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med 2010; 362: 1597–1604.
11. Raida L, Hluší A, Procházková J, et al. Idiopatická trombocytopenická purpura. Prakt. Lék. 2008; 88: 690–694.
12. Semple JW, Aslam R, Kim M, et al. Platelet-bound lipopolysaccharide enhances Fc receptormediated phagocytosis of IgG-opsonized platelets. Blood 2007; 109: 4803-4805.
13. Suzuki T, Matsushima M, Masui A, et al. Effect of Helicobacter pylori eradication in patiens with chronic idiopatic thrombocytopenic purpura –a randomized controlled trial. Am J Gastroenterol 2005; 100: 1265–1270.
14. Takahashi T, Yujiri T, Shinohara K, et al. Molecular mimicry by Helicobacter pylori CagA protein may be involved in the pathogenesis of H. pylori – associated chronic idiopathic thrombocytopenic purpura. Br J Haematol 2004; 124: 91–96.
15. Veneri D, De Matteis G, Solero P, et al. Analysis of B- and T cell clonality and HLA class II alleles in patients with idiopathic thrombocytopenic purpura: correlation with Helicobacter pylori infection and response to eradication treatment. Platelets 2005; 16: 307–311.
Labels
General practitioner for children and adolescents General practitioner for adultsArticle was published in
General Practitioner
2013 Issue 2
Most read in this issue
- Paretic symptoms and complications in aseptic CNS infections
- Cardiac computed tomography and its importance in cardiology K
- Helicobacter pylori infection and immune thrombocytopenic purpura – a case report
- Vascular and psychosocial risk factor of Alzheimer's disease